Biochemistry of arsenic detoxification
TLDR
While the overall schemes for arsenic resistance are similar in prokaryotes and eukaryotes, some of the specific proteins are the products of separate evolutionary pathways.About:
This article is published in FEBS Letters.The article was published on 2002-10-02 and is currently open access. It has received 726 citations till now. The article focuses on the topics: Arsenate reductase activity & Arsenate reductase.read more
Citations
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Genotoxicity Assessment of Mercuric Chloride in the Marine Fish Therapon jaruba
Sribas Goswami,Ramananda Goswami,N. Nagarani,A.K. Kumaraguru,Velmurugan Janaki Devi,Chandrasekaran Archana Devi +5 more
TL;DR: In this paper, the authors investigated the impact of coal mining on vegetation and agriculture in Raniganj and Jharia coalfields in India through a study based on empirical facts collected from various formal sources from Coal India office.
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Arsenite biotransformation and bioaccumulation by Klebsiella pneumoniae strain SSSW7 possessing arsenite oxidase (aioA) gene.
TL;DR: Arsenite oxidizing Klebsiella pneumoniae strain SSSW7 isolated from shipyard waste Goa, India might be employed as a potential candidate for bioremediation of arsenite contaminated environmental sites.
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A New Nonsymmetric As(OH)3 Species. Comparison with the Known C3 Species and Themochemistry at the HF, DFT(B3LYP), MP2, MP4, and CCSD(T) Levels of Theory
TL;DR: A new nonsymmetric As(OH)(3) species that is more stable than the C(3) structure is found at HF, Density Functional Theory (B3LYP), MP2, MP4 and CCSD(T) levels with the Stuttgart RECP-basis for As and the aug-cc-pvdz/pvtz extended basis sets.
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Arsenic resistance genes of As-resistant purple nonsulfur bacteria isolated from As-contaminated sites for bioremediation application.
Phitthaya Nookongbut,Duangporn Kantachote,Duangporn Kantachote,Kannan M. Krishnan,Mallavarapu Megharaj +4 more
TL;DR: The strain C1 has great potential for its application in bioremediation of As‐contaminated sites and exhibits the high activities of arsenite oxidase and arsenate reductase enzymes that are encoded by aioA and arsC genes, respectively.
Dissertation
Toxicity of alkylated derivatives of arsenic, antimony and tin in vitro: Cellular uptake, cytotoxicity, genotoxic effects, perturbation of Ca 2+ homeostasis, and cell death
TL;DR: In this paper, the authors investigated the toxicity of arsenic compounds in terms of cytotoxicity and DNA damage, and found that the cytotoxic effects were dose-dependent and inhibited at higher doses.
References
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Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.
TL;DR: Related sequences in both alpha and beta and in other enzymes that bind ATP or ADP in catalysis help to identify regions contributing to an adenine nucleotide binding fold in both ATP synthase subunits.
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CLUSTAL: A package for performing multiple sequence alignment on a microcomputer
Desmond G. Higgins,Paul M. Sharp +1 more
TL;DR: An approach for performing multiple alignments of large numbers of amino acid or nucleotide sequences is described, based on first deriving a phylogenetic tree from a matrix of all pairwise sequence similarity scores obtained using a fast pairwise alignment algorithm.
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Classification and evolution of P-loop GTPases and related ATPases.
TL;DR: In this article, the authors compared sequences and available structures for all the widely distributed representatives of the P-loop GTPases and GTPase-related proteins with the aim of constructing an evolutionary classification for this superclass of proteins and reconstructing the principal events in their evolution.
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Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells.
Miroslav Styblo,L.M. Del Razo,Libia Vega,Dori R. Germolec,Edward L. LeCluyse,G. Hamilton,W Reed,Changqing Wang,William R. Cullen,David J. Thomas +9 more
TL;DR: It is suggested that trivalent methylated arsenicals, intermediary products of arsenic methylation, may significantly contribute to the adverse effects associated with exposure to iAs, and high methylation capacity does not protect cells from the acute toxicity of triavalent arsenicals.
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The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.
Inka Leier,Gabriele Jedlitschky,Ulrike Buchholz,Susan P.C. Cole,Roger G. Deeley,Dietrich Keppler +5 more
TL;DR: It is concluded that the biosynthetic release of LTC4 from cells is mediated by the 190-kDa product of the MRP gene, a primary-active ATP-dependent export pump for conjugates of lipophilic compounds with glutathione and several other anionic residues.