Biochemistry of arsenic detoxification
TLDR
While the overall schemes for arsenic resistance are similar in prokaryotes and eukaryotes, some of the specific proteins are the products of separate evolutionary pathways.About:
This article is published in FEBS Letters.The article was published on 2002-10-02 and is currently open access. It has received 726 citations till now. The article focuses on the topics: Arsenate reductase activity & Arsenate reductase.read more
Citations
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Bacillus sp. SXB and Pantoea sp. IMH, aerobic As(V)‐reducing bacteria isolated from arsenic‐contaminated soil
TL;DR: To isolate highly effective aerobic As(V)‐reducing bacteria from arsenic(As)‐contaminated soils in Northwest China and to identify their dynamic As( V) reduction processes and genomic detoxification mechanisms.
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Identification of a Novel Membrane Transporter Mediating Resistance to Organic Arsenic in Campylobacter jejuni
Zhangqi Shen,Taradon Luangtongkum,Taradon Luangtongkum,Zhiyi Qiang,Byeonghwa Jeon,Liping Wang,Liping Wang,Qijing Zhang +7 more
TL;DR: Results indicate that ArsP functions as an efflux transporter specific for extrusion of organic arsenic and contributes to the resistance to these compounds in C. jejuni.
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Exaggerated arsenic nephrotoxicity in female mice through estrogen-dependent impairments in the autophagic flux.
Akihiko Kimura,Yuko Ishida,Mizuho Nosaka,Yumi Kuninaka,Mizuki Hama,Takashi Kawaguchi,Shoichi Sakamoto,Kohei Shinozaki,Yumi Iwahashi,Tatsunori Takayasu,Toshikazu Kondo +10 more
TL;DR: Estrogen has a negative impact on the development of NaAsO2 nephrotoxicity through its suppression of the autophagic flux, indicating that the hypersusceptibility of female mice is attributed to estrogen signals.
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Redox transformations of arsenic oxyanions in periphyton communities
TL;DR: The presence of a bacterial population within the periphyton communities that is capable of two key arsenic redox transformations that were previously studied in As-contaminated environments is demonstrated, which suggests that these processes are widely distributed in nature.
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Response to comments on "A bacterium that can grow using arsenic instead of phosphorus"
Felisa Wolfe-Simon,Felisa Wolfe-Simon,Jodi Switzer Blum,Thomas R. Kulp,Gwyneth W. Gordon,Shelley E. Hoeft,Jennifer Pett-Ridge,John F. Stolz,Samuel M. Webb,Peter K. Weber,Paul Davies,Paul Davies,Ariel D. Anbar,Ronald S. Oremland +13 more
TL;DR: Concerns have been raised about the recent study suggesting that arsenic (As) substitutes for phosphorus in major biomolecules of a bacterium that tolerates extreme As concentrations, but the authors maintain that their interpretation of As substitution, based on multiple congruent lines of evidence, is viable.
References
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Journal ArticleDOI
Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.
TL;DR: Related sequences in both alpha and beta and in other enzymes that bind ATP or ADP in catalysis help to identify regions contributing to an adenine nucleotide binding fold in both ATP synthase subunits.
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CLUSTAL: A package for performing multiple sequence alignment on a microcomputer
Desmond G. Higgins,Paul M. Sharp +1 more
TL;DR: An approach for performing multiple alignments of large numbers of amino acid or nucleotide sequences is described, based on first deriving a phylogenetic tree from a matrix of all pairwise sequence similarity scores obtained using a fast pairwise alignment algorithm.
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Classification and evolution of P-loop GTPases and related ATPases.
TL;DR: In this article, the authors compared sequences and available structures for all the widely distributed representatives of the P-loop GTPases and GTPase-related proteins with the aim of constructing an evolutionary classification for this superclass of proteins and reconstructing the principal events in their evolution.
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Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells.
Miroslav Styblo,L.M. Del Razo,Libia Vega,Dori R. Germolec,Edward L. LeCluyse,G. Hamilton,W Reed,Changqing Wang,William R. Cullen,David J. Thomas +9 more
TL;DR: It is suggested that trivalent methylated arsenicals, intermediary products of arsenic methylation, may significantly contribute to the adverse effects associated with exposure to iAs, and high methylation capacity does not protect cells from the acute toxicity of triavalent arsenicals.
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The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.
Inka Leier,Gabriele Jedlitschky,Ulrike Buchholz,Susan P.C. Cole,Roger G. Deeley,Dietrich Keppler +5 more
TL;DR: It is concluded that the biosynthetic release of LTC4 from cells is mediated by the 190-kDa product of the MRP gene, a primary-active ATP-dependent export pump for conjugates of lipophilic compounds with glutathione and several other anionic residues.