Biochemistry of arsenic detoxification
TLDR
While the overall schemes for arsenic resistance are similar in prokaryotes and eukaryotes, some of the specific proteins are the products of separate evolutionary pathways.About:
This article is published in FEBS Letters.The article was published on 2002-10-02 and is currently open access. It has received 726 citations till now. The article focuses on the topics: Arsenate reductase activity & Arsenate reductase.read more
Citations
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Journal ArticleDOI
Isolation and Characterization of NP4, Arsenate-Reducing Sulfurospirillum, from Maine Groundwater
TL;DR: An arsenate-reducing bacterium, designated NP4, was isolated from groundwater obtained from a well in Northport, Me., with extremely high (>1,400 μg L−1 ) arsenic.
Journal ArticleDOI
An Oxidoreductase AioE is Responsible for Bacterial Arsenite Oxidation and Resistance.
TL;DR: The results indicate that AioE may act as a novel AsIII oxidation electron transporter associated with NADH generation and the essential of aioE for AsIII resistance is also reasonable.
Journal ArticleDOI
Osmotic stress limits arsenic hypertolerance in Aspergillus sp. P37
David Cánovas,Víctor de Lorenzo +1 more
TL;DR: Intracellular accumulation of arsenic was affected by the presence of the osmolytes (NaCl or sorbitol), suggesting a major role for vacuoles in the detoxification of arsenic in Aspergillus.
Dissertation
Understanding the Encapsulins:Prediction and Characterization of Phage Capsid-like Nanocompartments in Prokaryotes
TL;DR: This thesis work utilized a bioinformatic approach to identify and investigate the functions of all encapsulins found in bacteria and Archaea, and identified four new enzyme families strongly predicted to be classical encapsulin cargo enzymes: ferredoxins, rubrerythrin- like, Dps-bacterioferritin-like, and hemerythrin-like proteins.
References
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Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.
TL;DR: Related sequences in both alpha and beta and in other enzymes that bind ATP or ADP in catalysis help to identify regions contributing to an adenine nucleotide binding fold in both ATP synthase subunits.
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CLUSTAL: A package for performing multiple sequence alignment on a microcomputer
Desmond G. Higgins,Paul M. Sharp +1 more
TL;DR: An approach for performing multiple alignments of large numbers of amino acid or nucleotide sequences is described, based on first deriving a phylogenetic tree from a matrix of all pairwise sequence similarity scores obtained using a fast pairwise alignment algorithm.
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Classification and evolution of P-loop GTPases and related ATPases.
TL;DR: In this article, the authors compared sequences and available structures for all the widely distributed representatives of the P-loop GTPases and GTPase-related proteins with the aim of constructing an evolutionary classification for this superclass of proteins and reconstructing the principal events in their evolution.
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Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells.
Miroslav Styblo,L.M. Del Razo,Libia Vega,Dori R. Germolec,Edward L. LeCluyse,G. Hamilton,W Reed,Changqing Wang,William R. Cullen,David J. Thomas +9 more
TL;DR: It is suggested that trivalent methylated arsenicals, intermediary products of arsenic methylation, may significantly contribute to the adverse effects associated with exposure to iAs, and high methylation capacity does not protect cells from the acute toxicity of triavalent arsenicals.
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The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.
Inka Leier,Gabriele Jedlitschky,Ulrike Buchholz,Susan P.C. Cole,Roger G. Deeley,Dietrich Keppler +5 more
TL;DR: It is concluded that the biosynthetic release of LTC4 from cells is mediated by the 190-kDa product of the MRP gene, a primary-active ATP-dependent export pump for conjugates of lipophilic compounds with glutathione and several other anionic residues.