Journal ArticleDOI
Brain Connectivity: Gender Makes a Difference
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TLDR
The literature provides convergent evidence for a substantial gender difference in brain connectivity within the human brain that possibly underlies gender-related cognitive differences and should be mandatory to take gender into account when designing experiments or interpreting results of brain connectivity/network in health and disease.Abstract:
It has been well known that gender plays a critical role in the anatomy and function of the human brain, as well as human behaviors. Recent neuroimaging studies have demonstrated gender effects on not only focal brain areas but also the connectivity between areas. Specifically, structural MRI and diffusion MRI data have revealed substantial gender differences in white matter-based anatomical connectivity. Structural MRI data further demonstrated gender differences in the connectivity revealed by morphometric correlation among brain areas. Functional connectivity derived from functional neuroimaging (e.g., functional MRI and PET) data is also modulated by gender. Moreover, male and female human brains display differences in the network topology that represents the organizational patterns of brain connectivity across the entire brain. In this review, the authors summarize recent findings in the multimodal brain connectivity/network research with gender, focusing on large-scale data sets derived from modern neuroimaging techniques. The literature provides convergent evidence for a substantial gender difference in brain connectivity within the human brain that possibly underlies gender-related cognitive differences. Therefore, it should be mandatory to take gender into account when designing experiments or interpreting results of brain connectivity/network in health and disease. Future studies will likely be conducted to explore the interdependence between gender-related brain connectivity/network and the gender-specific nature of brain diseases as well as to investigate gender-related characteristics of multimodal brain connectivity/network in the normal brain.read more
Citations
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Inherited Sex-Reversal Mutations in SRY Define a Functional Threshold of Gonadogenesis: Biochemical and Evolutionary Implications of a Rare Monogenic Syndrome
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Corpus Callosum and Word Reading in Adult Survivors of Childhood Posterior Fossa Tumors
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Characterization of dynamical neural activity by means of EEG data: application to schizophrenia
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Shared functional connections within and between cortical networks predict cognitive abilities in adult males and females
TL;DR: In this paper, the authors evaluate sex-independent and sex-specific relationships between functional connectivity and individual cognitive abilities in 392 healthy young adults (196 males) from the Human Connectome Project and reveal that largely overlapping connections between visual, dorsal attention, ventral attention, and temporal parietal networks are associated with better performance on crystallised and fluid cognitive tests in males and females.
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Variation within the visually evoked neurovascular coupling response of the posterior cerebral artery is not influenced by age or sex
Jack K. Leacy,Emily M Johnson,Lauren Lavoie,Diane N Macilwraith,Megan Bambury,Jason A. Martin,Eric F. Lucking,Andrea M. Linares,Gurkarn Saran,Dwayne P. Sheehan,Nishan Sharma,Trevor A. Day,Ken D. O'Halloran +12 more
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