Comparative genomics reveals convergent evolution between the bamboo-eating giant and red pandas.
Yibo Hu,Qi Wu,Shuai Ma,Tianxiao Ma,Lei Shan,Xiao Wang,Yonggang Nie,Zemin Ning,Li Yan,Yunfang Xiu,Fuwen Wei +10 more
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TLDR
Comparative genomic analyses revealed adaptively convergent genes potentially involved with pseudothumb development and essential bamboo nutrient utilization and found that the umami taste receptor gene TAS1R1 has been pseudogenized in both pandas.Abstract:
Phenotypic convergence between distantly related taxa often mirrors adaptation to similar selective pressures and may be driven by genetic convergence. The giant panda (Ailuropoda melanoleuca) and red panda (Ailurus fulgens) belong to different families in the order Carnivora, but both have evolved a specialized bamboo diet and adaptive pseudothumb, representing a classic model of convergent evolution. However, the genetic bases of these morphological and physiological convergences remain unknown. Through de novo sequencing the red panda genome and improving the giant panda genome assembly with added data, we identified genomic signatures of convergent evolution. Limb development genes DYNC2H1 and PCNT have undergone adaptive convergence and may be important candidate genes for pseudothumb development. As evolutionary responses to a bamboo diet, adaptive convergence has occurred in genes involved in the digestion and utilization of bamboo nutrients such as essential amino acids, fatty acids, and vitamins. Similarly, the umami taste receptor gene TAS1R1 has been pseudogenized in both pandas. These findings offer insights into genetic convergence mechanisms underlying phenotypic convergence and adaptation to a specialized bamboo diet.read more
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The Kalanchoë genome provides insights into convergent evolution and building blocks of crassulacean acid metabolism
Xiaohan Yang,Xiaohan Yang,Rongbin Hu,Hengfu Yin,Jerry Jenkins,Shengqiang Shu,Haibao Tang,Degao Liu,Deborah Weighill,Deborah Weighill,Won Cheol Yim,Jungmin Ha,Karolina Heyduk,David Goodstein,Hao-Bo Guo,Robert C. Moseley,Robert C. Moseley,Elisabeth Fitzek,Sara S. Jawdy,Zhihao Zhang,Meng Xie,James Hartwell,Jane Grimwood,Paul E. Abraham,Ritesh Mewalal,Juan D. Beltrán,Susanna F. Boxall,Louisa V. Dever,Kaitlin J. Palla,Kaitlin J. Palla,Rebecca L. Albion,Travis M. Garcia,Jesse A. Mayer,Sung Don Lim,Ching Man Wai,Paul Peluso,Robert Van Buren,Henrique Cestari De Paoli,Henrique Cestari De Paoli,Anne M. Borland,Anne M. Borland,Hong Guo,Jin-Gui Chen,Wellington Muchero,Yanbin Yin,Daniel Jacobson,Daniel Jacobson,Timothy J. Tschaplinski,Robert L. Hettich,Ray Ming,Ray Ming,Klaus Winter,Jim Leebens-Mack,J. Andrew C. Smith,John C. Cushman,Jeremy Schmutz,Gerald A. Tuskan +56 more
TL;DR: Evidence is provided for convergent evolution of protein sequence and temporal gene expression underpinning the multiple independent emergences of CAM through genomic analysis of Kalanchoë fedtschenkoi.
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The International Mouse Phenotyping Consortium (IMPC): a functional catalogue of the mammalian genome that informs conservation.
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TL;DR: Using gorilla genomic data, it is shown how genes essential to development in mice can be used to help assess the potentially deleterious impact of gene variants in other species, and how these analyses can be routinely applied.
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