Journal ArticleDOI
Creating, transporting, cutting, and merging liquid droplets by electrowetting-based actuation for digital microfluidic circuits
TLDR
In this paper, the authors report the completion of four fundamental fluidic operations considered essential to build digital microfluidic circuits, which can be used for lab-on-a-chip or micro total analysis system (/spl mu/TAS): 1) creating, 2) transporting, 3) cutting, and 4) merging liquid droplets, all by electrowetting.Abstract:
Reports the completion of four fundamental fluidic operations considered essential to build digital microfluidic circuits, which can be used for lab-on-a-chip or micro total analysis system (/spl mu/TAS): 1) creating, 2) transporting, 3) cutting, and 4) merging liquid droplets, all by electrowetting, i.e., controlling the wetting property of the surface through electric potential. The surface used in this report is, more specifically, an electrode covered with dielectrics, hence, called electrowetting-on-dielectric (EWOD). All the fluidic movement is confined between two plates, which we call parallel-plate channel, rather than through closed channels or on open surfaces. While transporting and merging droplets are easily verified, we discover that there exists a design criterion for a given set of materials beyond which the droplet simply cannot be cut by EWOD mechanism. The condition for successful cutting is theoretically analyzed by examining the channel gap, the droplet size and the degree of contact angle change by electrowetting on dielectric (EWOD). A series of experiments is run and verifies the criterion.read more
Citations
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Journal ArticleDOI
A Low-Cost Portable Dynamic Droplet Sensing System for Digital Microfluidics Applications
TL;DR: A simple and low-cost open electrowetting on dielectric (EWOD)-based dynamic droplet sensing system has been designed and fabricated to measure the droplet parameters and has the potential to be useful in many of the existing lab-on-chip (LOC) applications.
Journal ArticleDOI
Droplet centrifugation, droplet DNA extraction, and rapid droplet thermocycling for simpler and faster PCR assay using wire-guided manipulations.
David J. You,Jeong Yeol Yoon +1 more
TL;DR: The adaptability of the CNC system is demonstrated to replace many common laboratory tasks on a single platform (through re-programmability), in rapid succession (using droplets), and with a high level of accuracy and automation.
Journal ArticleDOI
A robust and scalable active-matrix driven digital microfluidic platform based on printed-circuit board technology
Xing Yaru,Liu Yu,Chen Rifei,Yuyan Li,Chengzhi Zhang,Youwei Jiang,Yao Lu,Bingcheng Lin,Peizhong Chen,Ruijun Tian,Xianming Liu,Xing Cheng +11 more
TL;DR: The design and the fabrication of a robust and scalable active-matrix driven digital microfluidic platform based on printed-circuit board technology is described and a pentapeptide is synthesized on the device within 30 minutes.
Journal ArticleDOI
Leveraging liquid dielectrophoresis for microfluidic applications
TL;DR: The integration and utility of liquid DEP and droplet DEP in providing rapid and automated sample handling and manipulation capabilities on a compact chip-based platform is examined.
Patent
Methods for screening proteins using dna encoded chemical libraries as templates for enzyme catalysis
TL;DR: In this article, the authors present methods, compositions and devices for screening a protein library for proteins having a desired activity, such as capable of catalyzing the formation of a bond between two reactants.
References
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Fundamentals of microfabrication
TL;DR: The second edition of the Fundamentals of Microfabrication as discussed by the authors provides an in-depth coverage of the science of miniaturization, its methods, and materials, from the fundamentals of lithography through bonding and packaging to quantum structures and molecular engineering.
Journal ArticleDOI
Electrowetting-based actuation of liquid droplets for microfluidic applications
TL;DR: In this article, a microactuator for rapid manipulation of discrete microdroplets is presented, which is accomplished by direct electrical control of the surface tension through two sets of opposing planar electrodes fabricated on glass.
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TL;DR: In this paper, the authors present an overview of Micromachining Techniques, Mechanical Transducers, Optical Transducers and Ionizing Radiation Transducers for Microfluidic Devices.
Journal ArticleDOI
Electrowetting-based actuation of droplets for integrated microfluidics
TL;DR: In this paper, an alternative approach to microfluidics based upon the micromanipulation of discrete droplets of aqueous electrolyte by electrowetting is reported.