Journal ArticleDOI
Creating, transporting, cutting, and merging liquid droplets by electrowetting-based actuation for digital microfluidic circuits
TLDR
In this paper, the authors report the completion of four fundamental fluidic operations considered essential to build digital microfluidic circuits, which can be used for lab-on-a-chip or micro total analysis system (/spl mu/TAS): 1) creating, 2) transporting, 3) cutting, and 4) merging liquid droplets, all by electrowetting.Abstract:
Reports the completion of four fundamental fluidic operations considered essential to build digital microfluidic circuits, which can be used for lab-on-a-chip or micro total analysis system (/spl mu/TAS): 1) creating, 2) transporting, 3) cutting, and 4) merging liquid droplets, all by electrowetting, i.e., controlling the wetting property of the surface through electric potential. The surface used in this report is, more specifically, an electrode covered with dielectrics, hence, called electrowetting-on-dielectric (EWOD). All the fluidic movement is confined between two plates, which we call parallel-plate channel, rather than through closed channels or on open surfaces. While transporting and merging droplets are easily verified, we discover that there exists a design criterion for a given set of materials beyond which the droplet simply cannot be cut by EWOD mechanism. The condition for successful cutting is theoretically analyzed by examining the channel gap, the droplet size and the degree of contact angle change by electrowetting on dielectric (EWOD). A series of experiments is run and verifies the criterion.read more
Citations
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Journal ArticleDOI
Droplet manipulation on a hydrophobic textured surface with roughened patterns
TL;DR: In this article, a novel concept is proposed and verified, experimentally and theoretically, to manipulate droplets without external power sources, which is a hydrophobic surface containing specific roughness gradients, composed of several textured regions with gradually increased structural roughness.
Journal ArticleDOI
Droplet-based pyrosequencing using digital microfluidics.
Deborah J. Boles,Jonathan L. Benton,Germaine J. Siew,Miriam H. Levy,Prasanna Thwar,Melissa Sandahl,Jeremy Rouse,Lisa Perkins,Arjun Sudarsan,Roxana Jalili,Vamsee K. Pamula,Vijay Srinivasan,Richard B. Fair,Peter B. Griffin,Allen E. Eckhardt,Michael G. Pollack +15 more
TL;DR: It is expected that longer reads, higher throughput, and improved process integration (i.e., "sample-to-sequence" capability) could eventually be achieved using this low-cost platform.
Journal ArticleDOI
Fundamentals and applications of electrowetting: A critical review
TL;DR: In this paper, a comprehensive review of electrowetting on dielectric (EWOD) is presented, and experiments, theoretical modeling and numerical simulations are covered, and some representative practical applications are then presented.
Patent
Methods and Microfluidic Devices for the Manipulation of Droplets in High Fidelity Polynucleotide Assembly
TL;DR: In this article, methods and devices for manipulating droplets on a support using surface tension properties, moving the droplets along a predetermined path and merging two droplets together enabling a number of chemical reactions are provided.
Journal ArticleDOI
A liquid-triggered liquid microvalve for on-chip flow control
Jessica Melin,Niclas Roxhed,Guillem Gimenez,Patrick Griss,Wouter van der Wijngaart,Göran Stemme +5 more
TL;DR: In this article, a surface tension and geometry based liquid-triggered liquid microvalve for on-chip liquid flow control is introduced, where simultaneous presence of two liquid plugs at the uncomplicated valve junction triggers the further movement of the liquids and overcomes the stop valve function of the device, thereby providing a precise means of timing liquid movement on chip.
References
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Book
Fundamentals of microfabrication
TL;DR: The second edition of the Fundamentals of Microfabrication as discussed by the authors provides an in-depth coverage of the science of miniaturization, its methods, and materials, from the fundamentals of lithography through bonding and packaging to quantum structures and molecular engineering.
Journal ArticleDOI
Electrowetting-based actuation of liquid droplets for microfluidic applications
TL;DR: In this article, a microactuator for rapid manipulation of discrete microdroplets is presented, which is accomplished by direct electrical control of the surface tension through two sets of opposing planar electrodes fabricated on glass.
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Micromachined Transducers Sourcebook
TL;DR: In this paper, the authors present an overview of Micromachining Techniques, Mechanical Transducers, Optical Transducers and Ionizing Radiation Transducers for Microfluidic Devices.
Journal ArticleDOI
Electrowetting-based actuation of droplets for integrated microfluidics
TL;DR: In this paper, an alternative approach to microfluidics based upon the micromanipulation of discrete droplets of aqueous electrolyte by electrowetting is reported.