Journal ArticleDOI
Creating, transporting, cutting, and merging liquid droplets by electrowetting-based actuation for digital microfluidic circuits
TLDR
In this paper, the authors report the completion of four fundamental fluidic operations considered essential to build digital microfluidic circuits, which can be used for lab-on-a-chip or micro total analysis system (/spl mu/TAS): 1) creating, 2) transporting, 3) cutting, and 4) merging liquid droplets, all by electrowetting.Abstract:
Reports the completion of four fundamental fluidic operations considered essential to build digital microfluidic circuits, which can be used for lab-on-a-chip or micro total analysis system (/spl mu/TAS): 1) creating, 2) transporting, 3) cutting, and 4) merging liquid droplets, all by electrowetting, i.e., controlling the wetting property of the surface through electric potential. The surface used in this report is, more specifically, an electrode covered with dielectrics, hence, called electrowetting-on-dielectric (EWOD). All the fluidic movement is confined between two plates, which we call parallel-plate channel, rather than through closed channels or on open surfaces. While transporting and merging droplets are easily verified, we discover that there exists a design criterion for a given set of materials beyond which the droplet simply cannot be cut by EWOD mechanism. The condition for successful cutting is theoretically analyzed by examining the channel gap, the droplet size and the degree of contact angle change by electrowetting on dielectric (EWOD). A series of experiments is run and verifies the criterion.read more
Citations
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Journal ArticleDOI
A digital microfluidic system for serological immunoassays in remote settings
Alphonsus H. C. Ng,Ryan Fobel,Christian Fobel,Julian Lamanna,Darius G. Rackus,Aimee Summers,Christopher Dixon,Michael D. M. Dryden,Charis Lam,Man Ho,Nooman S. Mufti,Victor Lee,Mohd Afiq Mohd Asri,Edward A. Sykes,M. Dean Chamberlain,Rachael Joseph,Maurice Ope,Heather M. Scobie,Alaine Knipes,Paul A. Rota,Nina Marano,Paul M. Chege,Mary Njuguna,Rosemary Nzunza,Ngina Kisangau,John Kiogora,Michael Karuingi,John Wagacha Burton,Peter Borus,Eugene Lam,Aaron R. Wheeler +30 more
TL;DR: A compact and portable, field-deployable, point-of-care system relying on digital microfluidics that can rapidly test a small volume of capillary blood for disease-specific antibodies for measles and rubella is described.
Journal ArticleDOI
Droplet microfluidics: fundamentals and its advanced applications
TL;DR: The droplet-based microfluidic systems have been shown to be compatible with many chemical and biological reagents and capable of performing a variety of operations that can be rendered programmable and reconfigurable as mentioned in this paper.
Journal ArticleDOI
A new angle on pluronic additives: advancing droplets and understanding in digital microfluidics.
TL;DR: Analysis of a series of eight amphiphilic droplet additives used as a solution to biofouling in digital microfluidics using serum-containing cell culture media as a model fluid shows that species with longer PPO chains are superior for enabling droplet motion and reducing biofOUling.
Journal ArticleDOI
Soft printing of droplets pre-metered by electrowetting
Ui-Chong Yi,Chang-Jin “Cj” Kim +1 more
TL;DR: In this paper, a new way of printing liquid droplets, supported by electrical control of surface wettability and geometric utilization of surface tension effects, is presented. But this method requires the droplets to be pre-metered or digitized by electrowetting-on-dielectric (EWOD) inside the printing head so that the conditions of the printing surface and environment do not affect the volume of the printed droplet.
Journal ArticleDOI
EWOD microfluidic systems for biomedical applications
TL;DR: The recent developments and studies of EWOD-based DMF systems for biomedical applications published mostly during the last 5 years are reviewed.
References
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Book
Fundamentals of microfabrication
TL;DR: The second edition of the Fundamentals of Microfabrication as discussed by the authors provides an in-depth coverage of the science of miniaturization, its methods, and materials, from the fundamentals of lithography through bonding and packaging to quantum structures and molecular engineering.
Journal ArticleDOI
Electrowetting-based actuation of liquid droplets for microfluidic applications
TL;DR: In this article, a microactuator for rapid manipulation of discrete microdroplets is presented, which is accomplished by direct electrical control of the surface tension through two sets of opposing planar electrodes fabricated on glass.
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Micromachined Transducers Sourcebook
TL;DR: In this paper, the authors present an overview of Micromachining Techniques, Mechanical Transducers, Optical Transducers and Ionizing Radiation Transducers for Microfluidic Devices.
Journal ArticleDOI
Electrowetting-based actuation of droplets for integrated microfluidics
TL;DR: In this paper, an alternative approach to microfluidics based upon the micromanipulation of discrete droplets of aqueous electrolyte by electrowetting is reported.