Journal ArticleDOI
Creating, transporting, cutting, and merging liquid droplets by electrowetting-based actuation for digital microfluidic circuits
TLDR
In this paper, the authors report the completion of four fundamental fluidic operations considered essential to build digital microfluidic circuits, which can be used for lab-on-a-chip or micro total analysis system (/spl mu/TAS): 1) creating, 2) transporting, 3) cutting, and 4) merging liquid droplets, all by electrowetting.Abstract:
Reports the completion of four fundamental fluidic operations considered essential to build digital microfluidic circuits, which can be used for lab-on-a-chip or micro total analysis system (/spl mu/TAS): 1) creating, 2) transporting, 3) cutting, and 4) merging liquid droplets, all by electrowetting, i.e., controlling the wetting property of the surface through electric potential. The surface used in this report is, more specifically, an electrode covered with dielectrics, hence, called electrowetting-on-dielectric (EWOD). All the fluidic movement is confined between two plates, which we call parallel-plate channel, rather than through closed channels or on open surfaces. While transporting and merging droplets are easily verified, we discover that there exists a design criterion for a given set of materials beyond which the droplet simply cannot be cut by EWOD mechanism. The condition for successful cutting is theoretically analyzed by examining the channel gap, the droplet size and the degree of contact angle change by electrowetting on dielectric (EWOD). A series of experiments is run and verifies the criterion.read more
Citations
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Journal ArticleDOI
Current commercialization status of electrowetting-on-dielectric (EWOD) digital microfluidics
Jia Li,Chang-Jin “Cj” Kim +1 more
TL;DR: The history around major EWOD products that hit the market are presented to show their winding paths to commercialization and the current state of product development is summarized to peek into the future.
Journal ArticleDOI
Microfluidic Systems for Biosensing
TL;DR: This review aims to summarize the recent advancements in two major types of micro fluidic systems, continuous and discrete MFS, as well as their biomedical applications and future trends of using MFS in detection at molecular or cellular level.
Journal ArticleDOI
A digital microfluidic electrochemical immunoassay
TL;DR: The first digital microfluidic immunoassay relying on electrochemical detection is introduced, compatible with clinical applications and the simplicity and the small size of the detector suggest utility in the future for portable analysis.
Journal ArticleDOI
Combining rails and anchors with laser forcing for selective manipulation within 2D droplet arrays.
TL;DR: By adding guiding rails within the microfluidic structure the authors can selectively fill large scale arrays with monodisperse droplets with significant control over their contents, and make a droplet array filled with 96 droplets containing different concentrations of fluorescent microparticles.
Journal ArticleDOI
Microfluidic Surface Plasmon Resonance Sensors: From Principles to Point-of-Care Applications.
Da-Shin Wang,Shih-Kang Fan +1 more
TL;DR: Another type of SPR sensor which utilizes localized SPR (LSPR), is based on metal nanostructures with surface plasmon modes at the structural interface, which is sensitive to the refractive index change of the local medium.
References
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TL;DR: The second edition of the Fundamentals of Microfabrication as discussed by the authors provides an in-depth coverage of the science of miniaturization, its methods, and materials, from the fundamentals of lithography through bonding and packaging to quantum structures and molecular engineering.
Journal ArticleDOI
Electrowetting-based actuation of liquid droplets for microfluidic applications
TL;DR: In this article, a microactuator for rapid manipulation of discrete microdroplets is presented, which is accomplished by direct electrical control of the surface tension through two sets of opposing planar electrodes fabricated on glass.
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TL;DR: In this paper, the authors present an overview of Micromachining Techniques, Mechanical Transducers, Optical Transducers and Ionizing Radiation Transducers for Microfluidic Devices.
Journal ArticleDOI
Electrowetting-based actuation of droplets for integrated microfluidics
TL;DR: In this paper, an alternative approach to microfluidics based upon the micromanipulation of discrete droplets of aqueous electrolyte by electrowetting is reported.