Journal ArticleDOI
Creating, transporting, cutting, and merging liquid droplets by electrowetting-based actuation for digital microfluidic circuits
TLDR
In this paper, the authors report the completion of four fundamental fluidic operations considered essential to build digital microfluidic circuits, which can be used for lab-on-a-chip or micro total analysis system (/spl mu/TAS): 1) creating, 2) transporting, 3) cutting, and 4) merging liquid droplets, all by electrowetting.Abstract:
Reports the completion of four fundamental fluidic operations considered essential to build digital microfluidic circuits, which can be used for lab-on-a-chip or micro total analysis system (/spl mu/TAS): 1) creating, 2) transporting, 3) cutting, and 4) merging liquid droplets, all by electrowetting, i.e., controlling the wetting property of the surface through electric potential. The surface used in this report is, more specifically, an electrode covered with dielectrics, hence, called electrowetting-on-dielectric (EWOD). All the fluidic movement is confined between two plates, which we call parallel-plate channel, rather than through closed channels or on open surfaces. While transporting and merging droplets are easily verified, we discover that there exists a design criterion for a given set of materials beyond which the droplet simply cannot be cut by EWOD mechanism. The condition for successful cutting is theoretically analyzed by examining the channel gap, the droplet size and the degree of contact angle change by electrowetting on dielectric (EWOD). A series of experiments is run and verifies the criterion.read more
Citations
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Patent
Methods and devices for nucleic acid synthesis
Joseph M. Jacobson,Li-yun A. Kung,Andrew Kirk Wilson,Senthil Ramu,Daniel Schindler,Michael E. Hudson +5 more
TL;DR: In this paper, the synthesis of polynucleotides having a predefined sequence on a support is discussed, as well as the assembly of the polynotides of interest onto an anchor support-bound oligonucleotide.
Journal ArticleDOI
Droplet Manipulations in Two Phase Flow Microfluidics
TL;DR: This review summarizes the currently existing techniques for manipulating droplets in two-phase flow microfluidics, and very recent developments like the use of acoustic waves, magnetic fields, surface energy wells, and electrostatic traps and rails are discussed.
Journal ArticleDOI
Ferrofluid droplet manipulation using an adjustable alternating magnetic field
TL;DR: In this paper, the characteristics of an adjustable alternating magnetic field generated by a magnetic coil for droplet manipulation was investigated which enables more control on droplet transport, and it can be considered as a suitable alternative for moving magnets or an array of micro-coils.
Journal ArticleDOI
Stimuli-responsive hydrogel patterns for smart microfluidics and microarrays.
TL;DR: The properties, functions and applications of stimuli-responsive hydrogel patterns in bioanalytical applications are highlighted and some representative examples in microfluidics and microarrays are presented.
Journal ArticleDOI
Droplet dynamics passing through obstructions in confined microchannel flow
TL;DR: In this paper, Lee et al. proposed two requirements for independent wetting on each cylinder: (i) low Ca droplet should be manipulated, and (ii) cylinder interval should be larger than channel width.
References
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Book
Fundamentals of microfabrication
TL;DR: The second edition of the Fundamentals of Microfabrication as discussed by the authors provides an in-depth coverage of the science of miniaturization, its methods, and materials, from the fundamentals of lithography through bonding and packaging to quantum structures and molecular engineering.
Journal ArticleDOI
Electrowetting-based actuation of liquid droplets for microfluidic applications
TL;DR: In this article, a microactuator for rapid manipulation of discrete microdroplets is presented, which is accomplished by direct electrical control of the surface tension through two sets of opposing planar electrodes fabricated on glass.
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Micromachined Transducers Sourcebook
TL;DR: In this paper, the authors present an overview of Micromachining Techniques, Mechanical Transducers, Optical Transducers and Ionizing Radiation Transducers for Microfluidic Devices.
Journal ArticleDOI
Electrowetting-based actuation of droplets for integrated microfluidics
TL;DR: In this paper, an alternative approach to microfluidics based upon the micromanipulation of discrete droplets of aqueous electrolyte by electrowetting is reported.