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Journal ArticleDOI

Creating, transporting, cutting, and merging liquid droplets by electrowetting-based actuation for digital microfluidic circuits

TLDR
In this paper, the authors report the completion of four fundamental fluidic operations considered essential to build digital microfluidic circuits, which can be used for lab-on-a-chip or micro total analysis system (/spl mu/TAS): 1) creating, 2) transporting, 3) cutting, and 4) merging liquid droplets, all by electrowetting.
Abstract
Reports the completion of four fundamental fluidic operations considered essential to build digital microfluidic circuits, which can be used for lab-on-a-chip or micro total analysis system (/spl mu/TAS): 1) creating, 2) transporting, 3) cutting, and 4) merging liquid droplets, all by electrowetting, i.e., controlling the wetting property of the surface through electric potential. The surface used in this report is, more specifically, an electrode covered with dielectrics, hence, called electrowetting-on-dielectric (EWOD). All the fluidic movement is confined between two plates, which we call parallel-plate channel, rather than through closed channels or on open surfaces. While transporting and merging droplets are easily verified, we discover that there exists a design criterion for a given set of materials beyond which the droplet simply cannot be cut by EWOD mechanism. The condition for successful cutting is theoretically analyzed by examining the channel gap, the droplet size and the degree of contact angle change by electrowetting on dielectric (EWOD). A series of experiments is run and verifies the criterion.

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"Plug-n-Play" Sensing with Digital Microfluidics.

TL;DR: This paper provides "proof of concept" for PnP-DMF using commercial biosensors for glucose and β-ketone, a custom paper-based electrochemical sensor for lactate, and a generic screen-printed electroanalytical cell, demonstrating that hot-swapping sensors between experiments allows for convenient implementation of complex processes such as automated analysis of blood samples by standard addition.
Journal ArticleDOI

Low voltage reversible electrowetting exploiting lubricated polymer honeycomb substrates

TL;DR: In this paper, a lowvoltage electrowetting-on-dielectric scheme realized with lubricated honeycomb polymer surfaces is reported, where polycarbonate honeycomb reliefs manufactured with the breathfigures self-assembly were impregnated with silicone and castor oils.
Journal ArticleDOI

Automatic droplet transportation on a plastic microfluidic device having wettability gradient surface

TL;DR: A microfluidic device that can automatically transport a droplet on a plastic plate that consists of a Cyclo Olefin Polymer (COP) plate and a SiO2 membrane and has wettability gradient surface succeeds in automatically transporting the droplet in an enclosed microchannel without evaporation.
Journal ArticleDOI

Fluorinated liquid-enabled protein handling and surfactant-aided crystallization for fully in situ digital microfluidic MALDI-MS analysis

TL;DR: The results presented here suggest that fluorinated liquids could also be used to minimize protein adsorption and improve crystallization in other types of lab-on-a-chip devices and applications.
References
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Book

Fundamentals of microfabrication

TL;DR: The second edition of the Fundamentals of Microfabrication as discussed by the authors provides an in-depth coverage of the science of miniaturization, its methods, and materials, from the fundamentals of lithography through bonding and packaging to quantum structures and molecular engineering.
Journal ArticleDOI

Electrowetting-based actuation of liquid droplets for microfluidic applications

TL;DR: In this article, a microactuator for rapid manipulation of discrete microdroplets is presented, which is accomplished by direct electrical control of the surface tension through two sets of opposing planar electrodes fabricated on glass.
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Micromachined Transducers Sourcebook

TL;DR: In this paper, the authors present an overview of Micromachining Techniques, Mechanical Transducers, Optical Transducers and Ionizing Radiation Transducers for Microfluidic Devices.
Journal ArticleDOI

Electrowetting-based actuation of droplets for integrated microfluidics

TL;DR: In this paper, an alternative approach to microfluidics based upon the micromanipulation of discrete droplets of aqueous electrolyte by electrowetting is reported.
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