Journal ArticleDOI
Creating, transporting, cutting, and merging liquid droplets by electrowetting-based actuation for digital microfluidic circuits
TLDR
In this paper, the authors report the completion of four fundamental fluidic operations considered essential to build digital microfluidic circuits, which can be used for lab-on-a-chip or micro total analysis system (/spl mu/TAS): 1) creating, 2) transporting, 3) cutting, and 4) merging liquid droplets, all by electrowetting.Abstract:
Reports the completion of four fundamental fluidic operations considered essential to build digital microfluidic circuits, which can be used for lab-on-a-chip or micro total analysis system (/spl mu/TAS): 1) creating, 2) transporting, 3) cutting, and 4) merging liquid droplets, all by electrowetting, i.e., controlling the wetting property of the surface through electric potential. The surface used in this report is, more specifically, an electrode covered with dielectrics, hence, called electrowetting-on-dielectric (EWOD). All the fluidic movement is confined between two plates, which we call parallel-plate channel, rather than through closed channels or on open surfaces. While transporting and merging droplets are easily verified, we discover that there exists a design criterion for a given set of materials beyond which the droplet simply cannot be cut by EWOD mechanism. The condition for successful cutting is theoretically analyzed by examining the channel gap, the droplet size and the degree of contact angle change by electrowetting on dielectric (EWOD). A series of experiments is run and verifies the criterion.read more
Citations
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Microparticle Concentration and Separation by Traveling-Wave Dielectrophoresis (twDEP) for Digital Microfluidics
TL;DR: In this paper, highly efficient in-droplet particle concentration and separation where particles are concentrated and separated into droplets by traveling-wave dielectrophoresis (DEP) and subsequent electrowetting-on-dielectric droplet splitting.
Journal ArticleDOI
Ionic-surfactant-mediated electro-dewetting for digital microfluidics
TL;DR: A method of droplet manipulation is described that uses electrical signals to induce the liquid to dewet, rather than wet, a hydrophilic conductive surface without the need for added layers, promising a simple and reliable microfluidic platform for a broad range of applications.
Journal ArticleDOI
A High-Performance Droplet Routing Algorithm for Digital Microfluidic Biochips
Minsik Cho,David Z. Pan +1 more
TL;DR: A high-performance droplet router for a digital microfluidic biochip (DMFB) design that achieves over 35 x and 20 x better routability with comparable timing and fault tolerance than the popular prioritized A* search and the state-of-the-art network-flow-based algorithm, respectively.
Journal ArticleDOI
Droplet-based micro oscillating-flow PCR chip
TL;DR: In this article, a droplet-based micro oscillating-flow PCR chip was designed and fabricated by the silicon microfabrication technique and three different temperature zones, which were stable at denaturation, extension and annealing temperatures, were integrated with a single, simple and straight microchannel to form the chip's basic functional structure.
Journal ArticleDOI
Electrowetting — From statics to dynamics
Longquan Chen,Elmar Bonaccurso +1 more
TL;DR: Some recent progress of fundamental understanding of electrowetting is reviewed and some still unsolved issues are addressed and some basic phenomena found in DC and AC Electrowetting are discussed, and some theories about the origin of contact angle saturation are introduced.
References
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Book
Fundamentals of microfabrication
TL;DR: The second edition of the Fundamentals of Microfabrication as discussed by the authors provides an in-depth coverage of the science of miniaturization, its methods, and materials, from the fundamentals of lithography through bonding and packaging to quantum structures and molecular engineering.
Journal ArticleDOI
Electrowetting-based actuation of liquid droplets for microfluidic applications
TL;DR: In this article, a microactuator for rapid manipulation of discrete microdroplets is presented, which is accomplished by direct electrical control of the surface tension through two sets of opposing planar electrodes fabricated on glass.
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Micromachined Transducers Sourcebook
TL;DR: In this paper, the authors present an overview of Micromachining Techniques, Mechanical Transducers, Optical Transducers and Ionizing Radiation Transducers for Microfluidic Devices.
Journal ArticleDOI
Electrowetting-based actuation of droplets for integrated microfluidics
TL;DR: In this paper, an alternative approach to microfluidics based upon the micromanipulation of discrete droplets of aqueous electrolyte by electrowetting is reported.