Journal ArticleDOI
Creating, transporting, cutting, and merging liquid droplets by electrowetting-based actuation for digital microfluidic circuits
TLDR
In this paper, the authors report the completion of four fundamental fluidic operations considered essential to build digital microfluidic circuits, which can be used for lab-on-a-chip or micro total analysis system (/spl mu/TAS): 1) creating, 2) transporting, 3) cutting, and 4) merging liquid droplets, all by electrowetting.Abstract:
Reports the completion of four fundamental fluidic operations considered essential to build digital microfluidic circuits, which can be used for lab-on-a-chip or micro total analysis system (/spl mu/TAS): 1) creating, 2) transporting, 3) cutting, and 4) merging liquid droplets, all by electrowetting, i.e., controlling the wetting property of the surface through electric potential. The surface used in this report is, more specifically, an electrode covered with dielectrics, hence, called electrowetting-on-dielectric (EWOD). All the fluidic movement is confined between two plates, which we call parallel-plate channel, rather than through closed channels or on open surfaces. While transporting and merging droplets are easily verified, we discover that there exists a design criterion for a given set of materials beyond which the droplet simply cannot be cut by EWOD mechanism. The condition for successful cutting is theoretically analyzed by examining the channel gap, the droplet size and the degree of contact angle change by electrowetting on dielectric (EWOD). A series of experiments is run and verifies the criterion.read more
Citations
More filters
Journal ArticleDOI
A 3D microblade structure for precise and parallel droplet splitting on digital microfluidic chips.
TL;DR: By taking synthetic DNA targets and their corresponding molecular beacon probes as a model system, multiple potential pathogens that cause sepsis are detected rapidly on the 3D-blade-equipped DMF chip, rendering it as a promising tool for parallel diagnosis of diseases.
Journal ArticleDOI
Serial dilution via surface energy trap-assisted magnetic droplet manipulation
TL;DR: This paper demonstrates a facile method of generating precise serial dilutions in the form of droplets on an open surface platform, using surface energy traps on a Teflon coated glass substrate for anti-microbial susceptibility testing (AST).
Journal ArticleDOI
Reversible electrowetting on silanized silicon nitride
Brian P. Cahill,A. T. Giannitsis,Raul Land,Gunter Gastrock,Uwe Pliquett,Dieter Frense,Mart Min,Dieter Beckmann +7 more
TL;DR: In this paper, the relationship between electrowetting and dielectric breakdown was tested by measuring the contact angle of a water droplet placed between two electrodes on an insulated surface.
Journal ArticleDOI
An Electrowetting Model For Rough Surfaces Under Low Voltage
Wei Dai,Ya-Pu Zhao +1 more
TL;DR: In this paper, a theoretical model for electrowetting is put forth to describe the dynamic electrical control of the wetting behavior at the low voltage, considering the surface topography, and the theoretical results are found to be in good agreement with the existing experimental results.
Patent
Assembly of high fidelity polynucleotides
TL;DR: In this article, support-bound template oligonucleotides are used to reduce sequence errors generated during synthesis of nucleic acids on a solid support, which can be used for a variety of applications, including synthesis of biofuels and value-added pharmaceutical products.
References
More filters
Book
Fundamentals of microfabrication
TL;DR: The second edition of the Fundamentals of Microfabrication as discussed by the authors provides an in-depth coverage of the science of miniaturization, its methods, and materials, from the fundamentals of lithography through bonding and packaging to quantum structures and molecular engineering.
Journal ArticleDOI
Electrowetting-based actuation of liquid droplets for microfluidic applications
TL;DR: In this article, a microactuator for rapid manipulation of discrete microdroplets is presented, which is accomplished by direct electrical control of the surface tension through two sets of opposing planar electrodes fabricated on glass.
Book
Micromachined Transducers Sourcebook
TL;DR: In this paper, the authors present an overview of Micromachining Techniques, Mechanical Transducers, Optical Transducers and Ionizing Radiation Transducers for Microfluidic Devices.
Journal ArticleDOI
Electrowetting-based actuation of droplets for integrated microfluidics
TL;DR: In this paper, an alternative approach to microfluidics based upon the micromanipulation of discrete droplets of aqueous electrolyte by electrowetting is reported.