Journal ArticleDOI
Critical roles of non-histone protein lysine methylation in human tumorigenesis
TLDR
The molecular functions of protein lysine methylation and its involvement in human cancer are summarized, with a particular focus on lysines methylation of non-histone proteins.Abstract:
Several protein lysine methyltransferases and demethylases have been identified to have critical roles in histone modification. A large body of evidence has indicated that their dysregulation is involved in the development and progression of various diseases, including cancer, and these enzymes are now considered to be potential therapeutic targets. Although most studies have focused on histone methylation, many reports have revealed that these enzymes also regulate the methylation dynamics of non-histone proteins such as p53, RB1 and STAT3 (signal transducer and activator of transcription 3), which have important roles in human tumorigenesis. In this Review, we summarize the molecular functions of protein lysine methylation and its involvement in human cancer, with a particular focus on lysine methylation of non-histone proteins.read more
Citations
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Electrostatic nucleic acid nanoassembly enables hybridization chain reaction in living cells for ultrasensitive mRNA imaging.
TL;DR: A novel electrostatic DNA nanoassembly is developed that realizes hybridization chain reaction (HCR), a target-initiated alternating hybridization reaction between two hairpin probes, for signal amplification in living cells and implies that the developed nanoassembly may provide an invaluable platform in low-abundance biomarker discovery and regulation for cell biology and theranostics.
Journal ArticleDOI
Regulation of the p53 response and its relationship to cancer.
TL;DR: P53 has been studied intensively as a major tumour suppressor that detects oncogenic events in cancer cells and eliminates them through senescence or apoptosis, and its regulatory contributions and ability to integrate signals from cellular events towards providing most appropriate response to stress conditions are examined.
Journal ArticleDOI
The roles of DNA, RNA and histone methylation in ageing and cancer.
Ewa M. Michalak,Ewa M. Michalak,Marian L. Burr,Marian L. Burr,Marian L. Burr,Andrew J. Bannister,Mark A. Dawson,Mark A. Dawson +7 more
TL;DR: The cellular functions of chromatin methylation are discussed and a perspective on the emerging data from early-phase clinical trial therapies that target regulators of DNA and histone methylation is provided.
Journal ArticleDOI
ADP-Ribosylation, a Multifaceted Posttranslational Modification Involved in the Control of Cell Physiology in Health and Disease.
Bernhard Lüscher,Mareike Bütepage,Laura Eckei,Sarah Krieg,Patricia Verheugd,Brian H. Shilton,Brian H. Shilton +6 more
TL;DR: The properties of the different enzymes associated with ADP-ribosylation and the consequences of this PTM on substrates are discussed and the different domains that interpret either mono- or poly-ADP- ribosylations and the implications for cellular processes are described.
Journal ArticleDOI
Recent Progress in Histone Demethylase Inhibitors
Tom E. McAllister,Katherine S. England,Richard J. Hopkinson,Paul Brennan,Paul Brennan,Akane Kawamura,Christopher J. Schofield +6 more
TL;DR: This review updates on previous reviews on the inhibition of the lysine-specific demethylases and JmjC families of N-methyl-lysine dem methylases and highlights recent biochemical, biological, and structural studies which are relevant to KDM inhibitor development.
References
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