Diet, the intestinal microbiota, and immune health in aging.
TLDR
Evidence supporting the role of diet and, in particular, dietary carbohydrate, protein, and fat in influencing the microbiota and its generation of key metabolites that influence the efficient functioning of immune cells during aging is reviewed and how dietary intervention might be of benefit in improving the intestinal health and immune status in the elderly is reviewed.Abstract:
Many countries are facing aging populations, with those over 65 years of age likely to represent the largest population over the next 10-20 years. Living longer often comes with poor health and, in particular, a decline in the immune function characterized by poor vaccine responses and increased risk of infection and certain cancers. Aging and diet represent major intrinsic and extrinsic factors that influence the makeup and activity of resident intestinal microbes, the microbiota, the efficient functioning of which is essential for sustaining overall health and the effectiveness of the immune system. The provision of elderly specific dietary recommendations appears to be lacking but is necessary since this population has an altered microbiota and immune response and may not respond in the same way as their healthy and younger counterparts. We have reviewed the evidence supporting the role of diet and, in particular, dietary carbohydrate, protein, and fat in influencing the microbiota and its generation of key metabolites that influence the efficient functioning of immune cells during aging, and how dietary intervention might be of benefit in improving the intestinal health and immune status in the elderly.read more
Citations
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Journal ArticleDOI
Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction.
Netusha Thevaranjan,Alicja Puchta,Christian Schulz,Avee Naidoo,Jake C. Szamosi,Chris P. Verschoor,Dessi Loukov,Louis P. Schenck,Jennifer Jury,Kevin P. Foley,Jonathan D. Schertzer,Maggie Larché,Donald J. Davidson,Elena F. Verdu,Michael G. Surette,Dawn M. E. Bowdish +15 more
TL;DR: It is found that, when maintained under germ-free conditions, mice do not display an age-related increase in circulating pro-inflammatory cytokine levels, suggesting that aging-associated microbiota promote inflammation and that reversing these age- related microbiota changes represents a potential strategy for reducing age-associated inflammation and the accompanying morbidity.
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D-Galactose-induced accelerated aging model: an overview.
TL;DR: The aim of this article is to comprehensively discuss the use of d-galactose to generate a model of accelerated aging and its possible underlying mechanisms involved in different tissues/organs.
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The impacts of natural polysaccharides on intestinal microbiota and immune responses - a review.
TL;DR: A comprehensive review is presented on the impacts of natural polysaccharides on the gut microbiota and immune responses, as well as their interactions.
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Predominant gut Lactobacillus murinus strain mediates anti-inflammaging effects in calorie-restricted mice
Fengwei Pan,Liying Zhang,Min Li,Yingxin Hu,Benhua Zeng,Huijuan Yuan,Liping Zhao,Chenhong Zhang +7 more
TL;DR: This study demonstrated that a strain of Lactobacillus murinus was promoted in CR mice and causatively contributed to the attenuation of ageing-associated inflammation.
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Inflammaging as a common ground for the development and maintenance of sarcopenia, obesity, cardiomyopathy and dysbiosis
TL;DR: It is hypothesized that sarcopenia, OBSP, CHF and dysbiosis are inflammaging-oriented disorders, whereby inflammaging is common and most probably the causative mechanism driving their pathogenesis.
References
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Journal ArticleDOI
Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa
Carlotta De Filippo,Duccio Cavalieri,Monica Di Paola,Matteo Ramazzotti,Jean Baptiste Poullet,Sébastien Massart,Silvia Collini,Giuseppe Pieraccini,Paolo Lionetti +8 more
TL;DR: In this paper, the authors compared the fecal microbiota of European children (EU) and that of children from a rural African village of Burkina Faso (BF), where the diet, high in fiber content, is similar to that of early human settlements at the time of the birth of agriculture.
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