Distinct characteristics of limbic-predominant age-related TDP-43 encephalopathy in Lewy body disease.
Maiko T. Uemura,John L. Robinson,Katheryn A.Q. Cousins,Thomas F. Tropea,Daniel C. Kargilis,Jennifer D. McBride,EunRan Suh,Sharon X. Xie,Yan Xu,Sílvia Porta,Norihito Uemura,Vivianna M. Van Deerlin,David A. Wolk,David J. Irwin,Kurt R. Brunden,Virginia M.-Y. Lee,Edward B. Lee,John Q. Trojanowski +17 more
TLDR
In this paper, the pathological, clinical, and genetic characteristics of LATE in LBD (LATE-LBD) by comparing it with LATE-AD, LATE with mixed pathology of LBD and AD, and LATE alone (pure LBD).Citations
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LATE-NC staging in routine neuropathologic diagnosis: an update
Peter T. Nelson,Edward A. Lee,Matthew D. Cykowski,Irina Alafuzoff,Konstantinos Arfanakis,Johannes Attems,Carol Brayne,Maria M. Corrada,Brittany N. Dugger,Margaret E. Flanagan,Bernardino Ghetti,Lea T. Grinberg,Murray Grossman,Michel J. Grothe,Glenda M. Halliday,Masato Hasegawa,Suvi R.K. Hokkanen,Sally Hunter,Kurt A. Jellinger,Claudia H. Kawas,C. Dirk Keene,Naomi Kouri,Gabor G. Kovacs,James B. Leverenz,Caitlin S. Latimer,Ian R. A. Mackenzie,Qinwen Mao,Kirsty E. McAleese,Richard S. Merrick,Thomas J. Montine,Melissa E. Murray,Liisa Myllykangas,Sukriti Nag,Janna H. Neltner,Kathy Newell,Robert A. Rissman,Yuko Saito,Seyed Ahmad Sajjadi,Katherine E. Schwetye,Andrew F. Teich,Dietmar Rudolf Thal,Sandra Tomé,Juan C. Troncoso,Shih-Hsiu Wang,Charles L. White,Thomas Wisniewski,Hyun-Sik Yang,Julie A. Schneider,Dennis W. Dickson,Manuela Neumann +49 more
TL;DR: In this paper , the authors proposed a classification system for limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC).
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Patterns of amygdala region pathology in LATE-NC: subtypes that differ with regard to TDP-43 histopathology, genetic risk factors, and comorbid pathologies
Matthew D. Cykowski,Anithachristy S. Arumanayagam,Suzanne Zein-Eldin Powell,Andreana L. Rivera,Erin L. Abner,Gustavo C. Román,Joseph C. Masdeu,Peter T. Nelson +7 more
TL;DR: The most common patterns were: Pattern 1, with lamina II TAR DNA-binding protein 43 kDa (TDP-43) + processes and preinclusion pathology in cortices of the amygdala region, and frequent LATE-NC Stage 3 with HS; Pattern 2, previously described as type-β, with neurofibrillary tangle-like TARP-43 neuronal cytoplasmic inclusions (NCIs), high Alzheimer's disease neuropathologic change (ADNC), frequent APOE ε4, and usually LATENC Stage 2; Pattern 3, with round NCIs and thick neurites in amygdala, younger age at death, and often comorbid Lewy body disease; and Pattern 4 (the most common pattern), with tortuous TARP processes in subpial and WM regions, low ADNC, rare HS, and lower dementia probability as discussed by the authors .
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Discrepancy between distribution of alpha-synuclein oligomers and Lewy-related pathology in Parkinson’s disease
Hiroaki Sekiya,Asato Tsuji,Yukihiko Hashimoto,Mariko Takata,Shunsuke Koga,Katsuya Nishida,Naonobu Futamura,Michi Kawamoto,Nobuo Kohara,Dennis W. Dickson,Hisatomo Kowa,Tatsushi Toda +11 more
TL;DR: In this paper , the distribution of α-synuclein (α-SYN)-positive inclusions referred to as Lewy bodies and Lewy neurites, collectively referred as Lewys-related pathology (LRP), was found to propagate in an ascending manner throughout the brain as the disease progresses.
Journal ArticleDOI
Discrepancy between distribution of alpha-synuclein oligomers and Lewy-related pathology in Parkinson’s disease
Hiroaki Sekiya,Asato Tsuji,Yuki Hashimoto,Mariko Takata,Shunsuke Koga,Katsuya Nishida,Naonobu Futamura,Michi Kawamoto,Nobuo Kohara,Dennis W. Dickson,Hisatomo Kowa,Tatsushi Toda +11 more
TL;DR: In this paper , the distribution of α-synuclein (α-SYN)-positive inclusions referred to as Lewy bodies and Lewy neurites, collectively referred as Lewys-related pathology (LRP), was found to propagate in an ascending manner throughout the brain as the disease progresses.
Journal ArticleDOI
Peripheral Pathways to Neurovascular Unit Dysfunction, Cognitive Impairment, and Alzheimer’s Disease
TL;DR: The idea that infections and organ dysfunction contribute to Alzheimer’s disease, through the generation of peripheral amyloids and/or neurovascular unit dysfunction will be explored and discussed.
References
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“Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician
Marshal F. Folstein,Marshal F. Folstein,Susan E B Folstein,Susan E B Folstein,Paul R. McHugh,Paul R. McHugh +5 more
TL;DR: A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
Journal ArticleDOI
Staging of brain pathology related to sporadic Parkinson’s disease
TL;DR: This study traces the course of the pathology in incidental and symptomatic Parkinson cases proposing a staging procedure based upon the readily recognizable topographical extent of the lesions.
Journal ArticleDOI
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
Manuela Neumann,Deepak M. Sampathu,Linda K. Kwong,Adam C. Truax,Matthew Micsenyi,Thomas T. Chou,Jennifer Bruce,Theresa Schuck,Murray Grossman,Christopher M. Clark,Leo McCluskey,Bruce L. Miller,Eliezer Masliah,Ian R. A. Mackenzie,Howard Feldman,Wolfgang Feiden,Hans A. Kretzschmar,John Q. Trojanowski,Virginia M.-Y. Lee +18 more
TL;DR: It is shown that TDP-43 is the major disease protein in both frontotemporal lobar degeneration with ubiquitin-positive inclusions and amyotrophic lateral sclerosis.
Journal ArticleDOI
Diagnosis and management of dementia with Lewy bodies: Third report of the DLB Consortium
Ian G. McKeith,Ian G. McKeith,Dennis W. Dickson,James Lowe,Murat Emre,John T. O'Brien,Howard Feldman,Jeffrey L. Cummings,John E. Duda,Carol F. Lippa,Elaine K. Perry,Dag Aarsland,Hiroyuki Arai,Clive Ballard,B. F. Boeve,David J. Burn,Durval C. Costa,T. Del Ser,Bruno Dubois,Douglas Galasko,Serge Gauthier,Christopher G. Goetz,Estrella Gómez-Tortosa,Glenda M. Halliday,L. A. Hansen,John Hardy,Takeshi Iwatsubo,Raj N. Kalaria,Daniel I. Kaufer,Rose Anne Kenny,Amos D. Korczyn,Kenji Kosaka,Virginia M.-Y. Lee,Andrew J. Lees,Irene Litvan,Elisabet Londos,Oscar L. Lopez,Satoshi Minoshima,Yoshikuni Mizuno,José Antonio Molina,Elizabeta B. Mukaetova-Ladinska,Florence Pasquier,Robert H. Perry,Jörg B. Schulz,John Q. Trojanowski,Masahito Yamada +45 more
TL;DR: The dementia with Lewy bodies (DLB) Consortium has revised criteria for the clinical and pathologic diagnosis of DLB incorporating new information about the core clinical features and suggesting improved methods to assess them as mentioned in this paper.
Journal ArticleDOI
Diagnosis and management of dementia with Lewy bodies Fourth consensus report of the DLB Consortium
Ian G. McKeith,Bradley F. Boeve,Dennis W. Dickson,Glenda M. Halliday,John-Paul Taylor,Daniel Weintraub,Dag Aarsland,Dag Aarsland,James E. Galvin,Johannes Attems,Johannes Attems,Clive Ballard,Clive Ballard,Ashley Bayston,Ashley Bayston,Thomas G. Beach,Thomas G. Beach,Frédéric Blanc,Nicolaas Bohnen,Nicolaas Bohnen,Nicolaas Bohnen,Laura Bonanni,Laura Bonanni,Jose Bras,Jose Bras,Patrik Brundin,Patrik Brundin,David J. Burn,David J. Burn,Alice Chen-Plotkin,John E. Duda,Omar M. A. El-Agnaf,Howard Feldman,Tanis J. Ferman,Dominic Ffytche,Hiroshige Fujishiro,Douglas Galasko,Jennifer G. Goldman,Stephen N. Gomperts,Neill R. Graff-Radford,Lawrence S. Honig,Lawrence S. Honig,Alex Iranzo,Alex Iranzo,Alex Iranzo,Kejal Kantarci,Daniel I. Kaufer,Walter Kukull,Virginia M.Y. Lee,James B. Leverenz,James B. Leverenz,Simon J.G. Lewis,Carol F. Lippa,Carol F. Lippa,Angela Lunde,M Masellis,M Masellis,M Masellis,Eliezer Masliah,Pamela J. McLean,Brit Mollenhauer,Brit Mollenhauer,Thomas J. Montine,Thomas J. Montine,Emilio Moreno,Emilio Moreno,Emilio Moreno,Etsuro Mori,Etsuro Mori,Etsuro Mori,Melissa E. Murray,John T. O'Brien,John T. O'Brien,Sotoshi Orimo,Sotoshi Orimo,Ronald B. Postuma,Ronald B. Postuma,Shankar Ramaswamy,Shankar Ramaswamy,Owen A. Ross,David P. Salmon,David P. Salmon,Andrew B. Singleton,Andrew B. Singleton,Angela Taylor,Angela Taylor,Alan Thomas,Pietro Tiraboschi,Jon B. Toledo,John Q. Trojanowski,Debby W. Tsuang,Zuzana Walker,Zuzana Walker,Masahito Yamada,Masahito Yamada,Kenji Kosaka +95 more
TL;DR: The Dementia with Lewy Bodies (DLB) Consortium has refined its recommendations about the clinical and pathologic diagnosis of DLB, updating the previous report, which has been in widespread use for the last decade.