Downregulation of NR3A-Containing NMDARs Is Required for Synapse Maturation and Memory Consolidation
Adam C. Roberts,Javier Díez-García,Ramona M. Rodriguiz,Icíar P. López,Rafael Luján,Rebeca Martínez-Turrillas,Esther Picó,Maile A. Henson,Danilo Bernardo,Thomas M. Jarrett,Dallis J. Clendeninn,Laura López-Mascaraque,Guoping Feng,Donald C. Lo,John F. Wesseling,William C. Wetsel,Benjamin D. Philpot,Isabel Pérez-Otaño +17 more
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TLDR
It is found that removal of NR3A is required to develop strong NMDAR currents, full expression of long-term synaptic plasticity, a mature synaptic organization characterized by more synapses and larger postsynaptic densities, and the ability to form long- term memories.About:
This article is published in Neuron.The article was published on 2009-08-13 and is currently open access. It has received 147 citations till now. The article focuses on the topics: Synapse maturation & Metaplasticity.read more
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Glutamate Receptor Ion Channels: Structure, Regulation, and Function
Stephen F. Traynelis,Lonnie P. Wollmuth,Chris J. McBain,Frank S. Menniti,Katie M. Vance,Kevin K. Ogden,Kasper B. Hansen,Hongjie Yuan,Scott J. Myers,Raymond Dingledine +9 more
TL;DR: This review discusses International Union of Basic and Clinical Pharmacology glutamate receptor nomenclature, structure, assembly, accessory subunits, interacting proteins, gene expression and translation, post-translational modifications, agonist and antagonist pharmacology, allosteric modulation, mechanisms of gating and permeation, roles in normal physiological function, as well as the potential therapeutic use of pharmacological agents acting at glutamate receptors.
Journal ArticleDOI
NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease
TL;DR: The effects of subunit composition on NMDAR properties, synaptic plasticity and cellular mechanisms implicated in neuropsychiatric disorders are reviewed and could provide new therapeutic strategies against dysfunctions of glutamatergic transmission.
Journal ArticleDOI
Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3
Xiaoming Wang,Portia A. McCoy,Ramona M. Rodriguiz,Yanzhen Pan,H. Shawn Je,Adam C. Roberts,Caroline J. Kim,Janet Berrios,Jennifer S. Colvin,Danielle Bousquet-Moore,Isabel Lorenzo,Gang Yi Wu,Richard J. Weinberg,Michael D. Ehlers,Michael D. Ehlers,Benjamin D. Philpot,Arthur L. Beaudet,William C. Wetsel,Yong-hui Jiang +18 more
TL;DR: It is concluded that loss of major Shank3 species produces biochemical, cellular and morphological changes, leading to behavioral abnormalities in mice that bear similarities to human ASD patients with SHANK3 mutations.
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Adolescence as a neurobiological critical period for the development of higher-order cognition.
Bart Larsen,Beatriz Luna +1 more
TL;DR: Understanding adolescence as a CP not only provides a mechanism for normative adolescent development, it provides a framework for understanding the role of experience and neurobiology in the emergence of psychopathology that occurs during this developmental period.
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