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Open AccessJournal ArticleDOI

Epistasis--the essential role of gene interactions in the structure and evolution of genetic systems.

Patrick C. Phillips
- 01 Nov 2008 - 
- Vol. 9, Iss: 11, pp 855-867
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TLDR
There is a renewed appreciation both for the importance of studying gene interactions and for addressing these questions in a unified, quantitative manner with the advent of high-throughput functional genomics.
Abstract: 
Epistasis, or interactions between genes, has long been recognized as fundamentally important to understanding the structure and function of genetic pathways and the evolutionary dynamics of complex genetic systems. With the advent of high-throughput functional genomics and the emergence of systems approaches to biology, as well as a new-found ability to pursue the genetic basis of evolution down to specific molecular changes, there is a renewed appreciation both for the importance of studying gene interactions and for addressing these questions in a unified, quantitative manner.

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Citations
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Journal ArticleDOI

A systems-based framework for understanding complex metabolic and cardiovascular disorders.

Sulin Wu, +2 more
- 01 Apr 2009 - 
TL;DR: By applying statistical methods, relationships between DNA variation, gene expression patterns, and diseases can be modeled.
Journal ArticleDOI

Advanced backcross quantitative trait locus analysis in winter wheat: Dissection of stripe rust seedling resistance and identification of favorable exotic alleles originated from a primary hexaploid wheat (Triticum turgidum ssp. dicoccoides × Aegilops tauschii)

Ali Ahmad Naz, +6 more
- 28 Feb 2012 - 
TL;DR: The AB-QTL (advanced backcross quantitative trait locus) strategy for the genetic dissection of complex disease resistance against stripe rust provides valuable new genetic resources to be used for stripe rust resistance breeding as well as to isolate new alleles of exotic origin.
Journal ArticleDOI

Identification of QTL underlying agronomic, morphological and physiological traits in barley under rainfed conditions using SNP markers

Osvin Arriagada, +3 more
- 17 May 2017 - 
TL;DR: The single-nucleotide polymorphisms associated with agronomic, morphological and physiological traits in a population of 137 recombinant chromosome substitution lines of barley, which were evaluated under rainfed conditions, are identified.
Journal ArticleDOI

Integrating Casein Complex SNPs Additive, Dominance and Epistatic Effects on Genetic Parameters and Breeding Values Estimation for Murciano-Granadina Goat Milk Yield and Components.

María Gabriela Pizarro Inostroza, +6 more
- 14 Mar 2020 - 
TL;DR: Conclusively, including genetic effects and relationships among these heritable biomarkers may improve model efficiency, genetic parameters, and breeding values for milk yield and composition, optimizing selection practices profitability for components whose technological application may be especially relevant for the cheese-making dairy sector.
Journal ArticleDOI

Analysis of recombination QTLs, segregation distortion, and epistasis for fitness in maize multiple populations using ultra-high-density markers

Chunhui Li, +8 more
- 05 Jul 2016 - 
TL;DR: It is found that the regions with high recombination rate and high gene density usually tended to have little segregation distortion, which will facilitate population genetic studies and gene cloning affecting recombination variation and segregation distortion in maize, which can improve plant breeding progress.
References
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Journal ArticleDOI

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Paul Burton, +195 more
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TL;DR: This study has demonstrated that careful use of a shared control group represents a safe and effective approach to GWA analyses of multiple disease phenotypes; generated a genome-wide genotype database for future studies of common diseases in the British population; and shown that, provided individuals with non-European ancestry are excluded, the extent of population stratification in theBritish population is generally modest.
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R. A. Fisher
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The Origins of Order: Self-Organization and Selection in Evolution

Stuart A. Kauffman
TL;DR: The structure of rugged fitness landscapes and the structure of adaptive landscapes underlying protein evolution, and the architecture of genetic regulatory circuits and its evolution.
Journal ArticleDOI

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

Ewan Birney, +320 more
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TL;DR: Functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project are reported, providing convincing evidence that the genome is pervasively transcribed, such that the majority of its bases can be found in primary transcripts.
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