Epistasis--the essential role of gene interactions in the structure and evolution of genetic systems.
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TLDR
There is a renewed appreciation both for the importance of studying gene interactions and for addressing these questions in a unified, quantitative manner with the advent of high-throughput functional genomics.Abstract:
Epistasis, or interactions between genes, has long been recognized as fundamentally important to understanding the structure and function of genetic pathways and the evolutionary dynamics of complex genetic systems. With the advent of high-throughput functional genomics and the emergence of systems approaches to biology, as well as a new-found ability to pursue the genetic basis of evolution down to specific molecular changes, there is a renewed appreciation both for the importance of studying gene interactions and for addressing these questions in a unified, quantitative manner.read more
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Journal ArticleDOI
Epistasis and natural selection shape the mutational architecture of complex traits.
TL;DR: An individual-based simulation model is used to investigate how natural selection and gene interactions shape the evolution of mutational processes affecting complex traits and finds that the presence of epistasis allows natural selection to mold the distribution of mutations, such that mutational effects align with the selection surface.
Journal ArticleDOI
High-order epistasis shapes evolutionary trajectories.
TL;DR: It is found that high-order epistasis strongly shapes the accessibility and probability of evolutionary trajectories through genotype-fitness maps and makes it impossible to predict evolutionary trajectoryories from the individual and paired effects of mutations.
Journal ArticleDOI
The Context-Dependence of Mutations: A Linkage of Formalisms.
TL;DR: Three theoretical frameworks that have been proposed for characterizing the epistasis between components of biological systems are described; these frameworks originate in different fields and use seemingly different calculations to describe the nonindependence of mutations.
Journal ArticleDOI
The differential view of genotype-phenotype relationships.
TL;DR: The differential view of GP relationships is shown to be a useful explanatory framework in the context of pervasive pleiotropy, epistasis, and environmental effects and clarifies the comparison between environmental and genetic effects on phenotypes.
Journal ArticleDOI
Mitochondrial-nuclear epistasis affects fitness within species but does not contribute to fixed incompatibilities between species of Drosophila.
TL;DR: It is proposed that a low mitochondrial substitution rate, resulting from a low mutation rate and/or efficient purifying selection, precludes the accumulation of mitochondrial–nuclear incompatibilities among these Drosophila species.
References
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TL;DR: This study has demonstrated that careful use of a shared control group represents a safe and effective approach to GWA analyses of multiple disease phenotypes; generated a genome-wide genotype database for future studies of common diseases in the British population; and shown that, provided individuals with non-European ancestry are excluded, the extent of population stratification in theBritish population is generally modest.
Book
The Origins of Order: Self-Organization and Selection in Evolution
TL;DR: The structure of rugged fitness landscapes and the structure of adaptive landscapes underlying protein evolution, and the architecture of genetic regulatory circuits and its evolution.
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Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
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TL;DR: Functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project are reported, providing convincing evidence that the genome is pervasively transcribed, such that the majority of its bases can be found in primary transcripts.
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