Fusobacterium nucleatum Acts as a Pro-carcinogenic Bacterium in Colorectal Cancer: From Association to Causality.
TLDR
In this paper, the authors summarized the biological characteristics of Fusobacterium nucleatum and the epidemiological associations between F. nucleatum, and highlighted the mechanisms by which F.ucleatum participates in CRC progression, metastasis, and chemoresistance by affecting cancer cells or regulating the tumor microenvironment.Abstract:
Colorectal cancer (CRC) is a common cancer worldwide with complex etiology. Fusobacterium nucleatum (F. nucleatum), an oral symbiotic bacterium, has been linked with CRC in the past decade. A series of gut microbiota studies show that CRC patients carry a high abundance of F. nucleatum in the tumor tissue and fecal, and etiological studies have clarified the role of F. nucleatum as a pro-carcinogenic bacterium in various stages of CRC. In this review, we summarize the biological characteristics of F. nucleatum and the epidemiological associations between F. nucleatum and CRC, and then highlight the mechanisms by which F. nucleatum participates in CRC progression, metastasis, and chemoresistance by affecting cancer cells or regulating the tumor microenvironment (TME). We also discuss the research gap in this field and give our perspective for future studies. These findings will pave the way for manipulating gut F. nucleatum to deal with CRC in the future.read more
Citations
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Mucosal Microbiota from Colorectal Cancer, Adenoma and Normal Epithelium Reveals the Imprint of Fusobacterium nucleatum in Cancerogenesis
Orazio Palmieri,Stefano Castellana,Anna Latiano,Tiziana Latiano,Annamaria Gentile,Anna Panza,M. Nardella,Davide Ciardiello,Giuseppe Corritore,Tommaso Mazza,Francesco Perri,Giuseppe Biscaglia +11 more
TL;DR: In this paper , a comprehensive view of the human mucosa-associated gut microbiota, emphasizing global microbial diversity mostly in synchronous lesions and proving the constant presence of Fusobacterium nucleatum, with its ability to drive carcinogenesis, was provided.
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The Association of Oral Microbiome Dysbiosis with Gastrointestinal Cancers and Its Diagnostic Efficacy
Pooria Asili,Maryam Mirahmad,Parisa Rezaei,Mohammad Hosein Mahdavi,Bagher Larijani,Seyed Mohammad Tavangar +5 more
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Microbiota, Oxidative Stress, and Skin Cancer: An Unexpected Triangle
Barbara Azzimonti,Chiara Ballacchino,P. Zanetta,Marie Angele Cucci,Chiara Monge,Margherita Grattarola,Chiara Dianzani,Giuseppina Barrera,Stefania Pizzimenti +8 more
TL;DR: The connection between microbiota, oxidative stress, and skin cancer is a largely unexplored field as discussed by the authors , although their interplay has been somewhat suggested, the current knowledge on these topics, suggesting potential therapeutic strategies.
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Keystone pathobionts associated with colorectal cancer promote oncogenic reprograming
TL;DR: Fusobacterium nucleatum (Fn) and Bacteroides fragilis (ETBF) are two pathobionts consistently enriched in the gut microbiomes of patients with colorectal cancer compared to healthy counterparts and frequently observed for their direct association within tumors as discussed by the authors .
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