Fusobacterium nucleatum Acts as a Pro-carcinogenic Bacterium in Colorectal Cancer: From Association to Causality.
TLDR
In this paper, the authors summarized the biological characteristics of Fusobacterium nucleatum and the epidemiological associations between F. nucleatum, and highlighted the mechanisms by which F.ucleatum participates in CRC progression, metastasis, and chemoresistance by affecting cancer cells or regulating the tumor microenvironment.Abstract:
Colorectal cancer (CRC) is a common cancer worldwide with complex etiology. Fusobacterium nucleatum (F. nucleatum), an oral symbiotic bacterium, has been linked with CRC in the past decade. A series of gut microbiota studies show that CRC patients carry a high abundance of F. nucleatum in the tumor tissue and fecal, and etiological studies have clarified the role of F. nucleatum as a pro-carcinogenic bacterium in various stages of CRC. In this review, we summarize the biological characteristics of F. nucleatum and the epidemiological associations between F. nucleatum and CRC, and then highlight the mechanisms by which F. nucleatum participates in CRC progression, metastasis, and chemoresistance by affecting cancer cells or regulating the tumor microenvironment (TME). We also discuss the research gap in this field and give our perspective for future studies. These findings will pave the way for manipulating gut F. nucleatum to deal with CRC in the future.read more
Citations
More filters
Journal ArticleDOI
Fusobacterium nucleatum: from a classic periodontal pathogen to a complete participant of carcinogenesis
TL;DR: Fusobacterium nucleatum is a component of the oral microflora, and in clinical practice it is associated primarily with periodontal diseases as mentioned in this paper , which has led to the discovery of mechanisms by which this bacterium may contribute to the development, metastasis of colorectal cancer and chemoresistance.
Journal ArticleDOI
Association between Diet and Fusobacterium nucleatum in the Feces of Healthy Adults: A hospital-based cross-sectional study.
Nobuhiro Narii,Ling Zha,Tomotaka Sobue,Tetsuhisa Kitamura,Satoshi Shiba,Sayaka Mizutani,Takuji Yamada,Shinichi Yachida +7 more
TL;DR: In this paper, the authors evaluated the association between various dietary factors and fecal Fusobacterium nucleatum in healthy adults without a history of colorectal cancer or precancerous lesions.
Journal ArticleDOI
Meta-analyses of host metagenomes from colorectal cancer patients reveal strong relationship between colorectal cancer-associated species.
TL;DR: In this paper , the authors evaluate the prevalence of microbial species in tumor by initially analyzing each dataset individually and subsequently intersecting the results for differentially abundant species between CRC and healthy samples.
Posted ContentDOI
Oral and anal microbiome from HIV-exposed individuals: role of host-associated factors in taxa composition and metabolic pathways.
TL;DR: In this article , the authors used shotgun metagenomics sequencing to characterize the oral and anal microbiome of men who have sex with men (MSM) and transgender women (TGW) with and without HIV.
Journal ArticleDOI
A spatial perspective on bacteria in tumours
Ilana Livyatan,Ravid Straussman +1 more
References
More filters
Journal ArticleDOI
Environmental and Heritable Factors in the Causation of Cancer — Analyses of Cohorts of Twins from Sweden, Denmark, and Finland
Paul Lichtenstein,Niels V. Holm,Pia K. Verkasalo,Anastasia Iliadou,Jaakko Kaprio,Jaakko Kaprio,Markku Koskenvuo,Markku Koskenvuo,Eero Pukkala,Axel Skytthe,Kari Hemminki +10 more
TL;DR: Inherited genetic factors make a minor contribution to susceptibility to most types of neoplasms, which indicates that the environment has the principal role in causing sporadic cancer.
Journal ArticleDOI
Colorectal cancer statistics, 2020.
Rebecca L. Siegel,Kimberly D. Miller,Ann Goding Sauer,Stacey A. Fedewa,Lynn F. Butterly,Lynn F. Butterly,Joseph C. Anderson,Joseph C. Anderson,Andrea Cercek,Robert A. Smith,Ahmedin Jemal +10 more
TL;DR: Progress against CRC can be accelerated by increasing access to guideline‐recommended screening and high‐quality treatment, particularly among Alaska Natives, and elucidating causes for rising incidence in young and middle‐aged adults.
Journal ArticleDOI
Understanding the tumor immune microenvironment (TIME) for effective therapy.
Mikhail Binnewies,Edward W. Roberts,Kelly Kersten,Vincent Chan,Douglas F. Fearon,Miriam Merad,Lisa M. Coussens,Dmitry I. Gabrilovich,Suzanne Ostrand-Rosenberg,Suzanne Ostrand-Rosenberg,Catherine C. Hedrick,Robert H. Vonderheide,Mikael J. Pittet,Rakesh K. Jain,Weiping Zou,T. Kevin Howcroft,Elisa C. Woodhouse,Robert A. Weinberg,Matthew F. Krummel +18 more
TL;DR: By parsing the unique classes and subclasses of tumor immune microenvironment (TIME) that exist within a patient’s tumor, the ability to predict and guide immunotherapeutic responsiveness will improve, and new therapeutic targets will be revealed.
Journal ArticleDOI
The Human Intestinal Microbiome in Health and Disease
Susan V. Lynch,Oluf Pedersen +1 more
TL;DR: The large majority of studies on the role of the microbiome in the pathogenesis of disease are correlative and preclinical; several have influenced clinical practice.
Journal ArticleDOI
Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment
Aleksandar Kostic,Aleksandar Kostic,Eunyoung Chun,Lauren Robertson,Jonathan N. Glickman,Carey Ann Gallini,Monia Michaud,Thomas E. Clancy,Thomas E. Clancy,Daniel C. Chung,Paul Lochhead,Georgina L. Hold,Emad M. El-Omar,Dean E. Brenner,Charles S. Fuchs,Matthew Meyerson,Matthew Meyerson,Wendy S. Garrett +17 more
TL;DR: Data suggest that, through recruitment of tumor-infiltrating immune cells, fusobacteria generate a proinflammatory microenvironment that is conducive for colorectal neoplasia progression, and this work finds that F.nucleatum does not exacerbate colitis, enteritis, or inflammation-associated intestinal carcinogenesis.