Fusobacterium nucleatum Acts as a Pro-carcinogenic Bacterium in Colorectal Cancer: From Association to Causality.
TLDR
In this paper, the authors summarized the biological characteristics of Fusobacterium nucleatum and the epidemiological associations between F. nucleatum, and highlighted the mechanisms by which F.ucleatum participates in CRC progression, metastasis, and chemoresistance by affecting cancer cells or regulating the tumor microenvironment.Abstract:
Colorectal cancer (CRC) is a common cancer worldwide with complex etiology. Fusobacterium nucleatum (F. nucleatum), an oral symbiotic bacterium, has been linked with CRC in the past decade. A series of gut microbiota studies show that CRC patients carry a high abundance of F. nucleatum in the tumor tissue and fecal, and etiological studies have clarified the role of F. nucleatum as a pro-carcinogenic bacterium in various stages of CRC. In this review, we summarize the biological characteristics of F. nucleatum and the epidemiological associations between F. nucleatum and CRC, and then highlight the mechanisms by which F. nucleatum participates in CRC progression, metastasis, and chemoresistance by affecting cancer cells or regulating the tumor microenvironment (TME). We also discuss the research gap in this field and give our perspective for future studies. These findings will pave the way for manipulating gut F. nucleatum to deal with CRC in the future.read more
Citations
More filters
Journal ArticleDOI
Oral microbiota in human systematic diseases
TL;DR: In this article , the authors discussed emerging and exciting evidence of complex and important connections between the oral microbes and multiple human systemic diseases, and the possible contribution of the oral microorganisms to systemic diseases.
Journal ArticleDOI
Integrated metagenomic and metabolomic analysis reveals distinct gut-microbiome-derived phenotypes in early-onset colorectal cancer
Cheng Kong,Lei Liang,Guang Liu,Lutao Du,Yongzhi Yang,Jianqiang Liu,Debing Shi,Xinxiang Li,Yan-yan Ma +8 more
TL;DR: The predictive model based on metagenomic, metabolomic and KO gene markers achieved a powerful classification performance for distinguishing EO-CRC from controls, suggesting that altered microbiome–metabolome interplay helps explain the pathogenesis of EO.CRC.
Journal ArticleDOI
Alterations in the Gut Microbiota and Their Metabolites in Colorectal Cancer: Recent Progress and Future Prospects
TL;DR: Gut microbiota and their metabolites influence the progression and causation of CRC, and the association analysis of metabolomics and gut microbiome will provide novel strategies for the prevention, diagnosis, and therapy of CRC.
Journal ArticleDOI
Dysbiosis of skin microbiome and gut microbiome in melanoma progression
Chahrazed Mekadim,Helena Kupcova Skalnikova,Jana Čížková,Veronika Cizkova,A Palanová,D. Horák,Jakub Mrázek +6 more
TL;DR: In this article , the authors examined associations between dysbiosis in the skin and gut microbiome and the melanoma growth using MeLiM porcine model of melanoma progression and spontaneous regression.
Journal ArticleDOI
Dysbiosis of skin microbiome and gut microbiome in melanoma progression
Chahrazed Mekadim,Helena Kupcova Skalnikova,Jana Čížková,Veronika Cizkova,A Palanová,D. Horák,Jakub Mrázek +6 more
TL;DR: In this article , the authors examined associations between dysbiosis in the skin and gut microbiome and the melanoma growth using MeLiM porcine model of melanoma progression and spontaneous regression.
References
More filters
Journal ArticleDOI
Host- and Microbiota-Derived Extracellular Vesicles, Immune Function, and Disease Development
TL;DR: Extracellular vesicles (EVs) are blebs of either plasma membrane or intracellular membranes carrying a cargo of proteins, nucleic acids, and lipids.
Journal ArticleDOI
Fusobacterium nucleatum host-cell binding and invasion induces IL-8 and CXCL1 secretion that drives colorectal cancer cell migration.
Michael A. Casasanta,Christopher C. Yoo,Barath Udayasuryan,Blake E. Sanders,Ariana Umaña,Yao Zhang,Huaiyao Peng,Alison J. Duncan,Yueying Wang,Liwu Li,Scott S. Verbridge,Daniel J. Slade +11 more
TL;DR: Inhibition of host-cell binding and invasion, potentially through vaccination or novel galactoside compounds, could be an effective strategy for reducing F. nucleatum invasion of tumor cells may reduce bacterial-associated gut inflammation and metastatic progression in CRC patients.
Journal ArticleDOI
Estimating the heritability of colorectal cancer
Shuo Jiao,Ulrike Peters,Sonja I. Berndt,Hermann Brenner,Katja Butterbach,Bette J. Caan,Christopher S. Carlson,Christopher S. Carlson,Christopher S. Carlson,Andrew T. Chan,Jenny Chang-Claude,Stephen J. Chanock,Keith R. Curtis,David J. Duggan,Jian Gong,Tabitha A. Harrison,Richard B. Hayes,Brian E. Henderson,Michael Hoffmeister,Laurence N. Kolonel,Loic Le Marchand,John D. Potter,Anja Rudolph,Robert E. Schoen,Daniela Seminara,Martha L. Slattery,Emily White,Li Hsu,Li Hsu +28 more
TL;DR: The results suggest that known CRC SNPs only explain a small proportion of the heritability and more common SNPs have yet to be identified.
Journal ArticleDOI
Fusobacterium Nucleatum Subspecies Animalis Influences Proinflammatory Cytokine Expression and Monocyte Activation in Human Colorectal Tumors
Xiangcang Ye,Rui Wang,Rajat Bhattacharya,Delphine R. Boulbes,Fan Fan,Ling Xia,Harish Adoni,Nadim J. Ajami,Matthew C. Wong,Daniel P. Smith,Joseph F. Petrosino,Susan Venable,Wei Qiao,Veerabhadran Baladandayuthapani,Dipen M. Maru,Lee M. Ellis +15 more
TL;DR: Observations suggested that infection with F. nucleatum ssp.
Journal ArticleDOI
Bacterial Biofilms in Colorectal Cancer Initiation and Progression
TL;DR: The concept that a polymicrobial biofilm promotes pro-carcinogenic activities that may partially underlie progression along the adenoma-CRC axis is explored.