Gene ontology annotations and resources
Judith A. Blake,Mary E. Dolan,H. Drabkin,David P. Hill,Li N,D. Sitnikov,Susan M. Bridges,Shane C. Burgess,Teresia Buza,Fiona M. McCarthy,Divyaswetha Peddinti,Lakshmi Pillai,Seth Carbon,Heiko Dietze,Amelia Ireland,Suzanna E. Lewis,Christopher J. Mungall,Pascale Gaudet,Chrisholm Rl,Petra Fey,Warren A. Kibbe,S. Basu,Deborah A. Siegele,B. K. McIntosh,Daniel P. Renfro,Adrienne E. Zweifel,James C. Hu,Nicholas H. Brown,Susan Tweedie,Yasmin Alam-Faruque,Rolf Apweiler,A. Auchinchloss,Kristian B. Axelsen,Benoit Bely,M. C. Blatter,Bonilla C,Bouguerleret L,Emmanuel Boutet,Lionel Breuza,Alan Bridge,W. M. Chan,Gayatri Chavali,Elisabeth Coudert,E. Dimmer,Anne Estreicher,L Famiglietti,Marc Feuermann,Arnaud Gos,Nadine Gruaz-Gumowski,Hieta R,Hinz C,Chantal Hulo,Rachael P. Huntley,J. James,Florence Jungo,Guillaume Keller,Kati Laiho,Duncan Legge,P. Lemercier,Damien Lieberherr,Michele Magrane,Maria Jesus Martin,Patrick Masson,Mutowo-Muellenet P,Claire O'Donovan,Ivo Pedruzzi,Klemens Pichler,Diego Poggioli,Porras Millán P,Sylvain Poux,Catherine Rivoire,Bernd Roechert,Tony Sawford,Michel Schneider,Andre Stutz,Shyamala Sundaram,Michael Tognolli,Ioannis Xenarios,Foulgar R,Jane Lomax,Paola Roncaglia,Varsha K. Khodiyar,Ruth C. Lovering,Philippa J. Talmud,Marcus C. Chibucos,Giglio Mg,Hsin-Yu Chang,Sarah Hunter,Craig McAnulla,Alex L. Mitchell,Sangrador A,Stephan R,Midori A. Harris,Stephen G. Oliver,Kim Rutherford,Wood,Jürg Bähler,Antonia Lock,Paul J. Kersey,McDowall Dm,Daniel M. Staines,Melinda R. Dwinell,Mary Shimoyama,Stan Laulederkind,Tom Hayman,Shur-Jen Wang,Timothy F. Lowry,P D'Eustachio,Lisa Matthews,Rama Balakrishnan,Gail Binkley,J. M. Cherry,Maria C. Costanzo,Selina S. Dwight,Engel,Dianna G. Fisk,Benjamin C. Hitz,Eurie L. Hong,Kalpana Karra,Miyasato,Robert S. Nash,Julie Park,Marek S. Skrzypek,Shuai Weng,Edith D. Wong,Tanya Z. Berardini,Eva Huala,Huaiyu Mi,Paul Thomas,Juancarlos Chan,Ranjana Kishore,Paul W. Sternberg,Van Auken K,Doug Howe,Monte Westerfield +134 more
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TLDR
The Gene Ontology (GO) Consortium is a community-based bioinformatics resource that classifies gene product function through the use of structured, controlled vocabularies and has been expanded not only to cover new areas of biology through focused interaction with experts, but also to capture greater specificity in all areas of the ontology.Abstract:
The Gene Ontology (GO) Consortium (GOC, http://www.geneontology.org) is a community-based bioinformatics resource that classifies gene product function through the use of structured, controlled vocabularies. Over the past year, the GOC has implemented several processes to increase the quantity, quality and specificity of GO annotations. First, the number of manual, literature-based annotations has grown at an increasing rate. Second, as a result of a new 'phylogenetic annotation' process, manually reviewed, homology-based annotations are becoming available for a broad range of species. Third, the quality of GO annotations has been improved through a streamlined process for, and automated quality checks of, GO annotations deposited by different annotation groups. Fourth, the consistency and correctness of the ontology itself has increased by using automated reasoning tools. Finally, the GO has been expanded not only to cover new areas of biology through focused interaction with experts, but also to capture greater specificity in all areas of the ontology using tools for adding new combinatorial terms. The GOC works closely with other ontology developers to support integrated use of terminologies. The GOC supports its user community through the use of e-mail lists, social media and web-based resources.read more
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ImmuCo: a database of gene co-expression in immune cells
TL;DR: A new database is reported, ImmuCo (http://immuco.bjmu.edu.cn), which is a cell-specific database that contains information about gene co- expression in immune cells, identifying co-expression and correlation between any two genes.
Journal ArticleDOI
Identification of new mechanisms of cellular response to chemotherapy by tracking changes in post-translational modifications by ubiquitin and ubiquitin-like proteins.
Thomas Bonacci,Stéphane Audebert,Luc Camoin,Emilie Baudelet,Ghislain Bidaut,Maxime Garcia,Ini Isabée Witzel,Neil D. Perkins,Jean-Paul Borg,Juan L. Iovanna,Philippe Soubeyran +10 more
TL;DR: The role of post-translational modifications (PTMs) mediated by members of the ubiquitin family are explored and gemcitabine-induced PTMs variations of relevant candidates are validated and the biological significance of such altered PTMs is demonstrated by studying in detail the sumoylation of SNIP1, one of these new targets.
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Genomics and bioinformatics resources for translational science in Rosaceae
Sook Jung,Dorrie Main +1 more
TL;DR: The currently available genomics and bioinformatics resources for the Rosaceae family are reviewed to provide utility for basic, translational and applied research.
Journal ArticleDOI
Analyses of effects of α-cembratrien-diol on cell morphology and transcriptome of Valsa mali var. mali.
Ning Yan,Yongmei Du,Xinmin Liu,Hongbo Zhang,Yanhua Liu,John Shi,Sophia Jun Xue,Zhongfeng Zhang +7 more
TL;DR: Gene Ontology term enrichment analysis revealed that α-cembratrien-diol substantially altered the expression of genes involved in the redox process, tetrapyrrole binding, coenzyme binding, heme binding, and iron binding; and Kyoto Encyclopedia of Genes and Genomes enrichment analysis showed significant enrichment of specific metabolic pathways involving the set of differentially expressed genes.
Journal ArticleDOI
PoSSuM v.2.0: data update and a new function for investigating ligand analogs and target proteins of small-molecule drugs
TL;DR: This release provides a new service named PoSSuM drug search (PoSSUMds) at http://possum.cbrc.jp/Po SSUM/drug_search/, in which it selected 194 approved drug compounds retrieved from ChEMBL, and detected their known binding pockets and pockets that are similar to them.
References
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Journal ArticleDOI
Gene Ontology: tool for the unification of biology
M Ashburner,Catherine A. Ball,Judith A. Blake,David Botstein,Heather Butler,J. M. Cherry,Allan Peter Davis,Kara Dolinski,Selina S. Dwight,J.T. Eppig,Midori A. Harris,David P. Hill,Laurie Issel-Tarver,Andrew Kasarskis,Suzanna E. Lewis,John C. Matese,Joel E. Richardson,M. Ringwald,Gerald M. Rubin,Gavin Sherlock +19 more
TL;DR: The goal of the Gene Ontology Consortium is to produce a dynamic, controlled vocabulary that can be applied to all eukaryotes even as knowledge of gene and protein roles in cells is accumulating and changing.
Journal ArticleDOI
The OBO Foundry : coordinated evolution of ontologies to support biomedical data integration
Barry Smith,Michael Ashburner,Cornelius Rosse,Jonathan Bard,William J. Bug,Werner Ceusters,Louis J. Goldberg,Karen Eilbeck,Amelia Ireland,Christopher J. Mungall,Neocles B. Leontis,Philippe Rocca-Serra,Alan Ruttenberg,Susanna-Assunta Sansone,Richard H. Scheuermann,Nigam H. Shah,Patricia L. Whetzel,Suzanna E. Lewis +17 more
TL;DR: This work describes the OBO Foundry initiative and provides guidelines for those who might wish to become involved and describes an expanding family of ontologies designed to be interoperable and logically well formed and to incorporate accurate representations of biological reality.
Conflict of interest statement. None declared.
TL;DR: It is found that women over 50 are more likely to have a family history of diabetes, especially if they are obese, than women under the age of 50.
Journal ArticleDOI
ChEBI: a database and ontology for chemical entities of biological interest
Kirill Degtyarenko,Paula de Matos,Marcus Ennis,Janna Hastings,Martin Zbinden,Alan McNaught,Rafael Alcántara,Michael Darsow,Mickaël Guedj,Michael Ashburner +9 more
TL;DR: A dictionary of molecular entities focused on ‘small’ chemical compounds and an ontological classification, whereby the relationships between molecular entities or classes of entities and their parents and/or children are specified.
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The OWL API: A Java API for OWL ontologies
Matthew Horridge,Sean Bechhofer +1 more
TL;DR: The OWL API is a high level Application Programming Interface (API) for working with OWL ontologies that supports parsing and rendering in the syntaxes defined in the W3C specification; manipulation of ontological structures; and the use of reasoning engines.
Related Papers (5)
Gene Ontology: tool for the unification of biology
M Ashburner,Catherine A. Ball,Judith A. Blake,David Botstein,Heather Butler,J. M. Cherry,Allan Peter Davis,Kara Dolinski,Selina S. Dwight,J.T. Eppig,Midori A. Harris,David P. Hill,Laurie Issel-Tarver,Andrew Kasarskis,Suzanna E. Lewis,John C. Matese,Joel E. Richardson,M. Ringwald,Gerald M. Rubin,Gavin Sherlock +19 more