Journal ArticleDOI
Genética de la cardiopatía isquémica: del conocimiento actual a las implicaciones clínicas
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TLDR
En este articulo se presenta una revision narrativa sobre el conocimiento actual of the genetica de esta patologia y sus implicaciones clinicas: the identificacion of dianas terapeuticas, the mejora en the prediccion del riesgo and the identification of pacientes respondedores o no respondedores a un tratamiento farmacologico.Abstract:
Resumen La cardiopatia isquemica continua siendo responsable de una gran morbilidad y mortalidad a nivel poblacional. Con el envejecimiento de la poblacion se espera que el numero de casos aumente en los proximos anos y su prevencion es un elemento importante en las politicas sanitarias. El riesgo de presentar cardiopatia isquemica esta relacionado con caracteristicas geneticas del individuo y su interaccion con factores ambientales y estilos de vida. En los ultimos anos se ha avanzado considerablemente en el conocimiento de las bases geneticas de la cardiopatia isquemica. En este articulo se presenta una revision narrativa sobre el conocimiento actual de la genetica de esta patologia y sus implicaciones clinicas: la identificacion de dianas terapeuticas, el estudio de la relacion causal entre un biomarcador y una enfermedad, la mejora en la prediccion del riesgo y la identificacion de pacientes respondedores o no respondedores a un tratamiento farmacologico.read more
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A common variant on chromosome 9p21 affects the risk of myocardial infarction
Anna Helgadottir,Gudmar Thorleifsson,Andrei Manolescu,Solveig Gretarsdottir,Thorarinn Blondal,Aslaug Jonasdottir,Abalbjorg Jonasdottir,Asgeir Sigurdsson,Adam Baker,Arnar Palsson,Gisli Masson,Daniel F. Gudbjartsson,Kristinn P. Magnusson,Karl Andersen,Allan I. Levey,Valgerdur M Backman,Sigurborg Matthiasdottir,Thorbjorg Jonsdottir,Stefan T Palsson,Helga Einarsdottir,Steinunn Gunnarsdottir,Arnaldur Gylfason,Viola Vaccarino,W. Craig Hooper,Muredach P. Reilly,Christopher B. Granger,Harland Austin,Daniel J. Rader,Svati H. Shah,Arshed A. Quyyumi,Jeffrey R. Gulcher,Gudmundur Thorgeirsson,Unnur Thorsteinsdottir,Augustine Kong,Kari Stefansson +34 more
TL;DR: An association between myocardial infarction and a common sequence variant on chromosome 9p21 was associated with the disease with high significance and approximately 21% of individuals in the population are homozygous for this variant, and their estimated risk of suffering myocardious disease is 1.64 times as great as that of noncarriers.
Genetic Markers Enhance Coronary Risk Prediction in Men: The MORGAM Prospective Cohorts
Maria Hughes,Olli Saarela,Jan Stritzke,Frank Kee,Kaisa Silander,Kaisa Silander,Norman Klopp,Jukka Kontto,Juha Karvanen,Christina Willenborg,Veikko Salomaa,Jarmo Virtamo,P. Amouyel,Dominique Arveiler,Jean Ferrières,Per-Gunner Wiklund,Jens Baumert,B Thorand,Patrick Diemert,David-Alexandre Trégouët,Christian Hengstenberg,Annette Peters,Alun Evans,Wolfgang Koenig,Jeanette Erdmann,Nilesh J. Samani,Kari Kuulasmaa,Heribert Schunkert +27 more
TL;DR: In this paper, a multilocus genetic risk score was proposed to refine coronary heart disease (CHD) prediction beyond classic risk scores and obtain more precise risk estimates using a prospective cohort design.
Journal ArticleDOI
Virtual reality and video games in cardiac rehabilitation programs. A systematic review.
Sara García-Bravo,Alicia Cuesta-Gómez,Raquel Campuzano-Ruiz,María Jesús López-Navas,Joaquín Domínguez-Paniagua,Aurora Araujo-Narváez,Estrella Barreñada-Copete,Cristina García-Bravo,Mariano Tomás Flórez-García,Javier Botas-Rodríguez,Roberto Cano-de-la-Cuerda +10 more
TL;DR: Virtual reality and videogames enhance motivation and adherence in cardiac rehabilitation programs and may promote heart rate, fatigue perception, physical activity and reduce pain in patients with cardiovascular diseases.
Journal ArticleDOI
Prioritization of causal genes for coronary artery disease based on cumulative evidence from experimental and in silico studies.
Alexandra S. Shadrina,Tatiana I. Shashkova,Tatiana I. Shashkova,Anna A. Torgasheva,Sodbo Zh Sharapov,Lucija Klaric,Eugene D Pakhomov,Dmitry G. Alexeev,James F. Wilson,Yakov A. Tsepilov,Peter K. Joshi,Yurii S. Aulchenko +11 more
TL;DR: This study aimed to prioritize CAD-relevant genes based on cumulative evidence from the published studies and study of colocalization between eQTLs and loci associated with CAD using SMR/HEIDI approach, and concluded that evidence for gene prioritization remains inconsistent, insufficient, or absent.
Journal ArticleDOI
Satisfaction with life and SF-36 vitality predict risk of ischemic heart disease: a prospective cohort study.
Cathrine Lawaetz Wimmelmann,Naja Kirstine Andersen,Marie Grønkjær,Emilie Rune Hegelund,Trine Flensborg-Madsen +4 more
TL;DR: In this article, the main objective of the study was to investigate associations between two aspects of well-being ( satisfaction with life and vitality) and incidence of and mortality from ischemic heart disease.
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Journal ArticleDOI
The International HapMap Project
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TL;DR: The HapMap will allow the discovery of sequence variants that affect common disease, will facilitate development of diagnostic tools, and will enhance the ability to choose targets for therapeutic intervention.
Journal ArticleDOI
A second generation human haplotype map of over 3.1 million SNPs
Kelly A. Frazer,Dennis G. Ballinger,David R. Cox,David A. Hinds,Laura L. Stuve,Richard A. Gibbs,John W. Belmont,Andrew Boudreau,Paul Hardenbol,Suzanne M. Leal,Shiran Pasternak,David A. Wheeler,Thomas D. Willis,Fuli Yu,Huanming Yang,Changqing Zeng,Gao Yang,H. B. Hu,Weitao Hu,Chaohua Li,Wei Lin,Siqi Liu,Hao Pan,Xiaoli Tang,Jian Wang,Wei Wang,Jun Yu,Bo Zhang,Qingrun Zhang,Hongbin Zhao,Hui Zhao,Jun Zhou,Stacey Gabriel,Rachel Barry,Brendan Blumenstiel,Amy L. Camargo,Matthew Defelice,Maura Faggart,Mary Goyette,Supriya Gupta,Jamie Moore,Huy Nguyen,Robert C. Onofrio,Melissa Parkin,Jessica Roy,Erich Stahl,Ellen Winchester,Liuda Ziaugra,David Altshuler,Yan Shen,Zhijian Yao,Wei Huang,Xun Chu,Yungang He,Li Jin,Yangfan Liu,Yayun Shen,Weiwei Sun,Haifeng Wang,Yi Wang,Ying Wang,Xiaoyan Xiong,Liang Xu,Mary M.Y. Waye,Stephen Kwok-Wing Tsui,Hong Xue,J. Tze Fei Wong,Luana Galver,Jian-Bing Fan,Kevin L. Gunderson,Sarah S. Murray,Arnold Oliphant,Mark S. Chee,Alexandre Montpetit,Fanny Chagnon,Vincent Ferretti,Martin Leboeuf,Jean François Olivier,Michael S. Phillips,Stéphanie Roumy,Clémentine Sallée,Andrei Verner,Thomas J. Hudson,Pui-Yan Kwok,Dongmei Cai,Daniel C. Koboldt,Raymond D. Miller,Ludmila Pawlikowska,Patricia Taillon-Miller,Ming Xiao,Lap-Chee Tsui,William Mak,Qiang Song You,Paul K.H. Tam,Yusuke Nakamura,Takahisa Kawaguchi,Takuya Kitamoto,Takashi Morizono,Atsushi Nagashima,Yozo Ohnishi,Akihiro Sekine,Toshihiro Tanaka,Tatsuhiko Tsunoda,Panos Deloukas,Christine P. Bird,Marcos Delgado,Emmanouil T. Dermitzakis,Rhian Gwilliam,Sarah E. Hunt,Jonathan J. Morrison,Don Powell,Barbara E. Stranger,Pamela Whittaker,David R. Bentley,Mark J. Daly,Paul I.W. de Bakker,Jeffrey C. Barrett,Yves Chretien,Julian Maller,Steve McCarroll,Nick Patterson,Itsik Pe'er,Alkes L. Price,Shaun Purcell,Daniel J. Richter,Pardis C. Sabeti,Richa Saxena,Stephen F. Schaffner,Pak C. Sham,Patrick Varilly,Lincoln Stein,Lalitha Krishnan,Albert V. Smith,Marcela K. Tello-Ruiz,Gudmundur A. Thorisson,Aravinda Chakravarti,Peter E. Chen,David J. Cutler,Carl S. Kashuk,Shin Lin,Gonçalo R. Abecasis,Weihua Guan,Yun Li,Heather M. Munro,Zhaohui S. Qin,Daryl J. Thomas,Gilean McVean,Adam Auton,Leonardo Bottolo,Niall Cardin,Susana Eyheramendy,Colin Freeman,Jonathan Marchini,Simon Myers,Chris C. A. Spencer,Matthew Stephens,Peter Donnelly,Lon R. Cardon,Geraldine M. Clarke,David M. Evans,Andrew P. Morris,Bruce S. Weir,Todd A. Johnson,James C. Mullikin,Stephen T. Sherry,Michael Feolo,Andrew D. Skol,Houcan Zhang,Ichiro Matsuda,Yoshimitsu Fukushima,Darryl Macer,Eiko Suda,Charles N. Rotimi,Clement Adebamowo,Ike Ajayi,Toyin Aniagwu,Patricia A. Marshall,Chibuzor Nkwodimmah,Charmaine D.M. Royal,Mark Leppert,Missy Dixon,Andy Peiffer,Renzong Qiu,Alastair Kent,Kazuto Kato,Norio Niikawa,Isaac F. Adewole,Bartha Maria Knoppers,Morris W. Foster,Ellen Wright Clayton,Jessica Watkin,Donna M. Muzny,Lynne V. Nazareth,Erica Sodergren,George M. Weinstock,Imtaz Yakub,Bruce W. Birren,Richard K. Wilson,Lucinda Fulton,Jane Rogers,John Burton,Nigel P. Carter,C M Clee,Mark Griffiths,Matthew C. Jones,Kirsten McLay,Robert W. Plumb,Mark T. Ross,Sarah Sims,David Willey,Zhu Chen,Hua Han,Le Kang,Martin Godbout,John C. Wallenburg,Paul L'Archevêque,Guy Bellemare,Koji Saeki,Hongguang Wang,Daochang An,Hongbo Fu,Qing Li,Zhen Wang,Renwu Wang,Arthur L. Holden,Lisa D. Brooks,Jean E. McEwen,Mark S. Guyer,Vivian Ota Wang,Jane Peterson,Michael Shi,Jack Spiegel,Lawrence M. Sung,Lynn F. Zacharia,Francis S. Collins,Karen Kennedy,Ruth Jamieson,John Stewart +237 more
TL;DR: The Phase II HapMap is described, which characterizes over 3.1 million human single nucleotide polymorphisms genotyped in 270 individuals from four geographically diverse populations and includes 25–35% of common SNP variation in the populations surveyed, and increased differentiation at non-synonymous, compared to synonymous, SNPs is demonstrated.
Journal ArticleDOI
2016 European Guidelines on cardiovascular disease prevention in clinical practice
Massimo Piepoli,Arno W. Hoes,Stefan Agewall,Christian Albus,Carlos Brotons,Alberico L. Catapano,Marie Therese Cooney,Ugo Corrà,Bernard Cosyns,Christi Deaton,Ian D. Graham,Michael Stephen Hall,FD Richard Hobbs,Maja-Lisa Løchen,Herbert Löllgen,Pedro Marques-Vidal,Joep Perk,Eva Prescott,Josep Redon,Dimitrios J. Richter,Naveed Sattar,Yvo M. Smulders,Monica Tiberi,H. Bart van der Worp,Ineke van Dis,W. M. Monique Verschuren +25 more
TL;DR: ABI is ankle-brachial (blood pressure) index and ABPM is ambulatory blood pressure monitoring as mentioned in this paper ; ACCORD is action to control cardiovascular risk in Diabetes and Vascular disease.