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Open AccessJournal ArticleDOI

Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary

TLDR
The assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation, and the concept of de‐escalation of therapy is introduced in the treatment assessment scheme.
Abstract
This Executive Summary of the Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 Report focuses primarily on the revised and novel parts of the document. The most significant changes include: (i) the assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation. ABCD groups are now proposed to be derived exclusively from patient symptoms and their history of exacerbations; (ii) for each of the groups A to D, escalation strategies for pharmacological treatments are proposed; (iii) the concept of de-escalation of therapy is introduced in the treatment assessment scheme; (iv)non-pharmacological therapies are comprehensively presented and (v) the importance of co-morbid conditions in managing COPD is reviewed.

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Dissertation

Geometria do ventrículo esquerdo em pacientes com DPOC: há associação com a limitação ao fluxo aéreo, capacidade funcional e força de preensão manual?

TL;DR: In COPD patients, LV concentric remodeling is associated with increased airflow limitation and decreased functional capacity, and increased LV mass isassociated with decreased handgrip strength.
Journal ArticleDOI

The Indices of Instantaneous Pulse Rate Variability Are Indicators for Daily Life Quality Assessment in Patients with COPD

TL;DR: This study showed the change in iPRV indices when the condition of COPD was improvement or exacerbation, a possible way to show how cardiovascular activity affects daily life quality in patients with COPD.
Journal ArticleDOI

Greek Guidelines for the Management of COPD, a Proposal of a Holistic Approach Based on the needs of the Greek Community

TL;DR: In this article , the Working Group of the Hellenic Thoracic Society aimed to consolidate the up-to-date information and new advances in the treatment of COPD, with revised strategies on the diagnostic approach and the evaluation of risk assessment and disease severity classification.
Journal ArticleDOI

Deregulation of Slug-Snail2 and TGF-β crosstalk in airway epithelial stem-progenitor cells: A key link between COPD and lung cancer?

Pascale Leroy
TL;DR: A potential central role of the crosstalk between Slug/Snail2 and TGF-β mechanisms is considered, and perspectives for identification of new biomarkers and/or therapeutic targets or therapy for preventing and treating these diseases are discussed.
Journal ArticleDOI

Emerging role of long non-coding RNA MALAT1 related signaling pathways in the pathogenesis of lung disease

TL;DR: The role and molecular mechanisms of MALAT1 in the pathogenesis of various lung diseases are discussed in this article , where a growing body of evidence suggests that aberrant expression of LncRN plays a key role in lung diseases, including chronic obstructive pulmonary diseases (COPD), Coronavirus Disease 2019 (COVID-19), acute respiratory distress syndrome (ARDS), lung cancers, and pulmonary hypertension through different mechanisms.
References
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TL;DR: Screening with the use of low-dose CT reduces mortality from lung cancer, as compared with the radiography group, and the rate of death from any cause was reduced.
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The Body-Mass Index, Airflow Obstruction, Dyspnea, and Exercise Capacity Index in Chronic Obstructive Pulmonary Disease

TL;DR: The BODE index, a simple multidimensional grading system, is better than the FEV1 at predicting the risk of death from any cause and from respiratory causes among patients with COPD.
Journal ArticleDOI

Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease.

TL;DR: The reduction in death from all causes among patients with COPD in the combination-therapy group did not reach the predetermined level of statistical significance, and there were significant benefits in all other outcomes among these patients.
Journal ArticleDOI

A self-complete measure of health status for chronic airflow limitation. The St. George's Respiratory Questionnaire.

TL;DR: The St. George's Respiratory Questionnaire is a valid measure of impaired health in diseases of chronic airflow limitation that is repeatable and sensitive andMultivariate analysis demonstrated that SGRQ scores summed a number of areas of disease activity.
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