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Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary

TLDR
The assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation, and the concept of de‐escalation of therapy is introduced in the treatment assessment scheme.
Abstract
This Executive Summary of the Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 Report focuses primarily on the revised and novel parts of the document. The most significant changes include: (i) the assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation. ABCD groups are now proposed to be derived exclusively from patient symptoms and their history of exacerbations; (ii) for each of the groups A to D, escalation strategies for pharmacological treatments are proposed; (iii) the concept of de-escalation of therapy is introduced in the treatment assessment scheme; (iv)non-pharmacological therapies are comprehensively presented and (v) the importance of co-morbid conditions in managing COPD is reviewed.

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Disruption of the Molecular Regulation of Mitochondrial Metabolism in Airway and Lung Epithelial Cells by Cigarette Smoke: Are Aldehydes the Culprit?

TL;DR: In this paper , the authors comprehensively describe and discuss the impact of acetaldehyde, acrolein, and formaldehyde on mitochondrial function and content and the molecular pathways controlling this (biogenesis versus mitophagy) in epithelial cells of the airways and lungs.
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Chronic Obstructive Pulmonary Disease Patients With High Peripheral Blood Eosinophil Counts Have Better Predicted Improvement in 6MWD After Rehabilitation

TL;DR: An 8-wk PR can improve the exercise capacity of COPD patients, and the benefits persistent for 24 wk, according to a statistically significant difference found in the 6MWT.
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Conscious sedation versus general anesthesia for transcatheter aortic valve implantation in patients with severe chronic obstructive pulmonary disease

TL;DR: In this article, the effects of different types of anesthesia on clinical outcomes in patients with severe COPD undergoing TAVI were investigated and the use of GA compared with CS was associated with higher incidences of respiratory-related complications, and longer ICU length of stay.

Asthma-COPD Overlap

TL;DR: Future research should be directed to determining phenotypes associated with ACO, their corresponding pathobiology, management, and long-term outcomes to address this common condition with a high burden of disease.
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Early home-based pulmonary rehabilitation following acute exacerbation of COPD: A feasibility study using an action research approach

TL;DR: Home-based PR improved clinical outcomes, but program eligibility and uptake remain challenging, and efforts should be made to ensure PR program eligibility criteria are broad enough to accommodate patient needs.
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Journal ArticleDOI

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A self-complete measure of health status for chronic airflow limitation. The St. George's Respiratory Questionnaire.

TL;DR: The St. George's Respiratory Questionnaire is a valid measure of impaired health in diseases of chronic airflow limitation that is repeatable and sensitive andMultivariate analysis demonstrated that SGRQ scores summed a number of areas of disease activity.
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