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Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary

TLDR
The assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation, and the concept of de‐escalation of therapy is introduced in the treatment assessment scheme.
Abstract
This Executive Summary of the Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 Report focuses primarily on the revised and novel parts of the document. The most significant changes include: (i) the assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation. ABCD groups are now proposed to be derived exclusively from patient symptoms and their history of exacerbations; (ii) for each of the groups A to D, escalation strategies for pharmacological treatments are proposed; (iii) the concept of de-escalation of therapy is introduced in the treatment assessment scheme; (iv)non-pharmacological therapies are comprehensively presented and (v) the importance of co-morbid conditions in managing COPD is reviewed.

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Exacerbation of Elastase-Induced Emphysema via Increased Oxidative Stress in Metallothionein-Knockout Mice

TL;DR: Analysis of the elastase-induced lung injury model using metallothionein-knockout (MT-KO; MT-1 and -2 gene deletion) mice suggests that metallothsionein protein, or compounds that can induce metallOTHionein, could be useful in the treatment of COPD.
Journal ArticleDOI

Machine learning for nocturnal diagnosis of chronic obstructive pulmonary disease using digital oximetry biomarkers.

TL;DR: In this article, the feasibility of automated COPD diagnosis using a data-driven analysis of the nocturnal continuous oximetry time series was evaluated using a random forest (RF) classifier.
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Year in review 2016: Chronic obstructive pulmonary disease and asthma.

TL;DR: This research presents a new probabilistic method called “cell reprograming” that allows for real-time analysis of the response of the immune system to drugs and its role in promoting healthy aging.
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High cytomegalovirus serology and subsequent COPD-related mortality: a longitudinal study

TL;DR: Using a 45-year longitudinal population-based cohort, it was demonstrated for the first time that high CMV serology predicts COPD mortality risk, particularly in younger subjects, identifying a novel and early risk factor for COPDortality.
Posted ContentDOI

Stable Chronic Obstructive Pulmonary Disease (COPD) Management Under a Tiered Medical System in China

TL;DR: Differences exist in the diagnosis, treatment and management of COPD among different tiers of hospitals in East China, and teaching and second-tier hospitals can manage COPD patients relatively well.
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Journal ArticleDOI

A self-complete measure of health status for chronic airflow limitation. The St. George's Respiratory Questionnaire.

TL;DR: The St. George's Respiratory Questionnaire is a valid measure of impaired health in diseases of chronic airflow limitation that is repeatable and sensitive andMultivariate analysis demonstrated that SGRQ scores summed a number of areas of disease activity.
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