Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary
Claus Vogelmeier,Gerard J. Criner,Fernando J. Martinez,Antonio Anzueto,Peter J. Barnes,Jean Bourbeau,Bartolome R. Celli,Rongchang Chen,Marc Decramer,Leonardo M. Fabbri,Peter Frith,David M.G. Halpin,M. Victorina López Varela,Masaharu Nishimura,Nicolas Roche,Roberto Rodriguez-Roisin,Don D. Sin,Dave Singh,Robert Stockley,Jørgen Vestbo,Jadwiga A. Wedzicha,Alvar Agusti +21 more
TLDR
The assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation, and the concept of de‐escalation of therapy is introduced in the treatment assessment scheme.Abstract:
This Executive Summary of the Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 Report focuses primarily on the revised and novel parts of the document. The most significant changes include: (i) the assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation. ABCD groups are now proposed to be derived exclusively from patient symptoms and their history of exacerbations; (ii) for each of the groups A to D, escalation strategies for pharmacological treatments are proposed; (iii) the concept of de-escalation of therapy is introduced in the treatment assessment scheme; (iv)non-pharmacological therapies are comprehensively presented and (v) the importance of co-morbid conditions in managing COPD is reviewed.read more
Citations
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Health status decline in α-1 antitrypsin deficiency: a feasible outcome for disease modifying therapies?
TL;DR: Despite AATD being a rapidly declining form of COPD, deterioration in SGRQ was slow consistent with ageing and the chronic nature of disease progression, which has important implications for future study design of disease modifying therapies even in COPD not associated with AATd.
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The SARS-CoV-2 Transcriptome and the Dynamics of the S Gene Furin Cleavage Site in Primary Human Airway Epithelia.
Wei Zou,Min Xiong,Siyuan Hao,Elizabeth Yan Zhang,Nathalie Baumlin,Michael D. Kim,Matthias Salathe,Ziying Yan,Jianming Qiu +8 more
TL;DR: In this article, the authors studied the viral transcriptome in Vero cell-derived SARS-CoV-2-infected primary human airway epithelia (HAE) cultured at an air-liquid interface (ALI) with an emphasis on the viral genome stability of the FCS.
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Do sputum or circulating blood samples reflect the pulmonary transcriptomic differences of COPD patients? A multi-tissue transcriptomic network META-analysis
Rosa Faner,Jarrett D. Morrow,Sandra Casas-Recasens,Suzanne M. Cloonan,Guillaume Noell,Alejandra López-Giraldo,Ruth Tal-Singer,Bruce E. Miller,Edwin K. Silverman,Alvar Agusti,Craig P. Hersh +10 more
TL;DR: These observations indicate that major differences in lung tissue transcriptomics in patients with COPD are poorly mirrored in sputum and are unrelated to those determined in blood, suggesting that the systemic component in COPD is independently regulated.
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Bone morphogenetic protein 6 (BMP-6) modulates lung function, pulmonary iron levels and cigarette smoke-induced inflammation.
Fien M. Verhamme,E G De Smet,W Van Hooste,Joris R. Delanghe,Stijn E. Verleden,Guy Joos,Guy Brusselle,Ken R. Bracke +7 more
TL;DR: It is suggested that B MP-6 is important for normal lung function and that downregulation of BMP-6—as observed in patients with COPD—contributes to pulmonary inflammation after CS exposure.
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Endotoxin-Induced Emphysema Exacerbation: A Novel Model of Chronic Obstructive Pulmonary Disease Exacerbations Causing Cardiopulmonary Impairment and Diaphragm Dysfunction.
Milena V. Oliveira,Nazareth N. Rocha,Nazareth N. Rocha,Raquel Souza Santos,Marcella Rieken Macedo Rocco,R.F. Magalhães,Johnatas D. Silva,Sergio Augusto Lopes de Souza,Vera Luiza Capelozzi,Paolo Pelosi,Pedro L. Silva,Patricia R. M. Rocco +11 more
TL;DR: A model of endotoxin-induced emphysema exacerbation that affected not only the lungs but also the heart and diaphragm, thus resembling several features of human disease is developed to allow preclinical testing of novel therapies with potential for translation into clinical practice.
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