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Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary

TLDR
The assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation, and the concept of de‐escalation of therapy is introduced in the treatment assessment scheme.
Abstract
This Executive Summary of the Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 Report focuses primarily on the revised and novel parts of the document. The most significant changes include: (i) the assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation. ABCD groups are now proposed to be derived exclusively from patient symptoms and their history of exacerbations; (ii) for each of the groups A to D, escalation strategies for pharmacological treatments are proposed; (iii) the concept of de-escalation of therapy is introduced in the treatment assessment scheme; (iv)non-pharmacological therapies are comprehensively presented and (v) the importance of co-morbid conditions in managing COPD is reviewed.

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Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles

TL;DR: The advantages of various drug delivery vehicles are discussed for better understanding of their utility in terms of current medical needs and the application of a wide range of nanomedicines is also described in the context of major chronic diseases.
Journal ArticleDOI

COPD Guidelines: A Review of the 2018 GOLD Report.

TL;DR: The salient features of the GOLD 2018 document are reviewed and commentary on features that merit further discussion are provided based on clinical experience and practice as well as literature review current as of February 2018.
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Chronic obstructive pulmonary disease in China: a nationwide prevalence study

TL;DR: The estimated overall prevalence of COPD in China in 2014–15 was 13·6%, indicating that this disease has become a major public-health problem.
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Antibiotics for exacerbations of chronic obstructive pulmonary disease

TL;DR: In this article, the effects of antibiotics in the management of acute COPD exacerbations on treatment failure and other patient-important outcomes (mortality, adverse events, length of hospital stay) were assessed.

A Randomized Clinical Trial of a 1 -Antitrypsin Augmentation Therapy

TL;DR: For example, Dirksen et al. as discussed by the authors investigated whether restoration of the balance between neutrophil elastase and its inhibitor, a 1 -antitrypsin, can prevent the progression of pulmonary emphysema in patients with a deficiency.
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Bronchiectasis, exacerbation indices, and inflammation in chronic obstructive pulmonary disease.

TL;DR: Evidence of moderate lower lobe bronchiectasis on HRCT is common in COPD and is associated with more severe COPD exacerbations, lower airway bacterial colonization, and increased sputum inflammatory markers.

E-cigarettes: an evidence update. A report commissioned by Public Health England.

TL;DR: There is no evidence that EC are undermining the long-term decline in cigarette smoking among adults and youth, and may in fact be contributing to it, and new regulations currently planned should also maximise the public health opportunities of EC.
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The Italian multicentre study on noninvasive ventilation in chronic obstructive pulmonary disease patients

TL;DR: The addition of noninvasive positive-pressure ventilation to long-term oxygen therapy in stable chronic obstructive pulmonary disease patients with chronic ventilatory failure slightly decreased the trend to carbon dioxide retention in patients receiving oxygen at home and improved dyspnoea and health-related quality of life.
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