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Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary

TLDR
The assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation, and the concept of de‐escalation of therapy is introduced in the treatment assessment scheme.
Abstract
This Executive Summary of the Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 Report focuses primarily on the revised and novel parts of the document. The most significant changes include: (i) the assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation. ABCD groups are now proposed to be derived exclusively from patient symptoms and their history of exacerbations; (ii) for each of the groups A to D, escalation strategies for pharmacological treatments are proposed; (iii) the concept of de-escalation of therapy is introduced in the treatment assessment scheme; (iv)non-pharmacological therapies are comprehensively presented and (v) the importance of co-morbid conditions in managing COPD is reviewed.

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Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles

TL;DR: The advantages of various drug delivery vehicles are discussed for better understanding of their utility in terms of current medical needs and the application of a wide range of nanomedicines is also described in the context of major chronic diseases.
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COPD Guidelines: A Review of the 2018 GOLD Report.

TL;DR: The salient features of the GOLD 2018 document are reviewed and commentary on features that merit further discussion are provided based on clinical experience and practice as well as literature review current as of February 2018.
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Chronic obstructive pulmonary disease in China: a nationwide prevalence study

TL;DR: The estimated overall prevalence of COPD in China in 2014–15 was 13·6%, indicating that this disease has become a major public-health problem.
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Associations of ambient air pollution with chronic obstructive pulmonary disease hospitalization and mortality.

TL;DR: Ambient air pollution, including traffic-related fine particulate pollution and woodsmoke pollution, is associated with an increased risk of COPD.
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The scientific rationale for combining long-acting beta2-agonists and muscarinic antagonists in COPD.

TL;DR: The scientific rationale for combining LABAs and LAMAs in COPD, the clinical evidence to support these agents given in combination, and their potential role in the management of patients with COPD are illustrated.
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Nocturnal non-invasive ventilation in COPD patients with prolonged hypercapnia after ventilatory support for acute respiratory failure: a randomised, controlled, parallel-group study

TL;DR: It is found that there is no reason to believe the NIV was not effective since daytime PaCO2 and night-time PCO2 improved and HRQL showed a trend in favour of NIV, and the trend for improvement in HRQL favouring NIV should be explored further.
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Integrated disease management interventions for patients with chronic obstructive pulmonary disease

TL;DR: Compared with controls, IDM showed a statistically and clinically significant improvement in disease-specific QoL on all domains of the Chronic Respiratory Questionnaire after 12 months and quality of evidence was scored as high quality, and on the CRQ as moderate quality evidence.
Journal ArticleDOI

Electronic Cigarettes for Smoking Cessation: A Systematic Review

TL;DR: The majority of included studies found that e-cigarettes, especially second-generation types, could alleviate smoking withdrawal symptoms and cravings in laboratory settings, suggesting e-cigarette may be helpful for some smokers for quitting or reducing smoking.
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