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Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary

TLDR
The assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation, and the concept of de‐escalation of therapy is introduced in the treatment assessment scheme.
Abstract
This Executive Summary of the Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 Report focuses primarily on the revised and novel parts of the document. The most significant changes include: (i) the assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation. ABCD groups are now proposed to be derived exclusively from patient symptoms and their history of exacerbations; (ii) for each of the groups A to D, escalation strategies for pharmacological treatments are proposed; (iii) the concept of de-escalation of therapy is introduced in the treatment assessment scheme; (iv)non-pharmacological therapies are comprehensively presented and (v) the importance of co-morbid conditions in managing COPD is reviewed.

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Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles

TL;DR: The advantages of various drug delivery vehicles are discussed for better understanding of their utility in terms of current medical needs and the application of a wide range of nanomedicines is also described in the context of major chronic diseases.
Journal ArticleDOI

COPD Guidelines: A Review of the 2018 GOLD Report.

TL;DR: The salient features of the GOLD 2018 document are reviewed and commentary on features that merit further discussion are provided based on clinical experience and practice as well as literature review current as of February 2018.
Journal ArticleDOI

Chronic obstructive pulmonary disease in China: a nationwide prevalence study

TL;DR: The estimated overall prevalence of COPD in China in 2014–15 was 13·6%, indicating that this disease has become a major public-health problem.
References
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Journal ArticleDOI

"GOLD or lower limit of normal definition? A comparison with expert-based diagnosis of chronic obstructive pulmonary disease in a prospective cohort-study".

TL;DR: GOLD criteria over-diagnosed COPD, while LLN definitions under-diagnose COPD in elderly patients as compared to an expert panel diagnosis, and incorporation of FEV1 and RV/TLC into the GOLD-COPD or LLN-based definition brings both definitions closer to expert paneldiagnosis, and to daily clinical practice.
Journal ArticleDOI

Augmentation therapy for alpha1 antitrypsin deficiency: a meta-analysis.

TL;DR: This meta-analysis supports the conclusion that augmentation can slow lung function decline in patients with AAT deficiency and patients with moderate obstruction are most likely to benefit.
Journal ArticleDOI

Use of inhaled corticosteroids and the risk of tuberculosis

TL;DR: ICS use increases the risk of TB in an intermediate-TB-burden country and Clinicians should be aware of the possibility of TB development among patients who are long-term high-dose ICS users.
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