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Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary

TLDR
The assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation, and the concept of de‐escalation of therapy is introduced in the treatment assessment scheme.
Abstract
This Executive Summary of the Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 Report focuses primarily on the revised and novel parts of the document. The most significant changes include: (i) the assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation. ABCD groups are now proposed to be derived exclusively from patient symptoms and their history of exacerbations; (ii) for each of the groups A to D, escalation strategies for pharmacological treatments are proposed; (iii) the concept of de-escalation of therapy is introduced in the treatment assessment scheme; (iv)non-pharmacological therapies are comprehensively presented and (v) the importance of co-morbid conditions in managing COPD is reviewed.

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Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles

TL;DR: The advantages of various drug delivery vehicles are discussed for better understanding of their utility in terms of current medical needs and the application of a wide range of nanomedicines is also described in the context of major chronic diseases.
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COPD Guidelines: A Review of the 2018 GOLD Report.

TL;DR: The salient features of the GOLD 2018 document are reviewed and commentary on features that merit further discussion are provided based on clinical experience and practice as well as literature review current as of February 2018.
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Chronic obstructive pulmonary disease in China: a nationwide prevalence study

TL;DR: The estimated overall prevalence of COPD in China in 2014–15 was 13·6%, indicating that this disease has become a major public-health problem.
References
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Journal ArticleDOI

Survival after bilateral versus single lung transplantation for patients with chronic obstructive pulmonary disease: a retrospective analysis of registry data

TL;DR: Bilateral lung transplantation leads to longer survival than single lung transplants in patients with COPD, especially those who are younger than 60 years, and had little benefit compared with single Lung Transplantation for patients who were 60 years and older.
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The National Emphysema Treatment Trial (NETT) Part II: Lessons learned about lung volume reduction surgery.

TL;DR: What the authors currently know about the role of LVRS in the treatment of severe emphysema is summarized as a result of insights gained from the NETT and a brief review of the newer techniques of lung volume reduction are provided.
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Does the Clinical Examination Predict Airflow Limitation

TL;DR: Airflow limitation is a disorder known by many names, including airway obstruction and obstructive airways disease, which can lead to appropriate treatment and can yield important prognostic information.
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Risk of death and readmission of hospital-admitted COPD exacerbations: European COPD Audit

TL;DR: Investigating the patient, resource and organisational factors associated with in-hospital and 90-day post-discharge mortality and readmission of COPD exacerbations within the European COPD Audit found deficiencies in acute COPD care such as making spirometry available and measuring blood gases and providing noninvasive ventilation more regularly would provide opportunities to improve COPD outcomes.
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Lung function impairment, COPD hospitalisations and subsequent mortality

TL;DR: COPD severity was associated with a higher rate of severe exacerbation requiring hospitalisation, although severe exacerbations at any stage were associated withA higher risk of short-term and long-term all-cause mortality.
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