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Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary

TLDR
The assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation, and the concept of de‐escalation of therapy is introduced in the treatment assessment scheme.
Abstract
This Executive Summary of the Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 Report focuses primarily on the revised and novel parts of the document. The most significant changes include: (i) the assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation. ABCD groups are now proposed to be derived exclusively from patient symptoms and their history of exacerbations; (ii) for each of the groups A to D, escalation strategies for pharmacological treatments are proposed; (iii) the concept of de-escalation of therapy is introduced in the treatment assessment scheme; (iv)non-pharmacological therapies are comprehensively presented and (v) the importance of co-morbid conditions in managing COPD is reviewed.

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Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles

TL;DR: The advantages of various drug delivery vehicles are discussed for better understanding of their utility in terms of current medical needs and the application of a wide range of nanomedicines is also described in the context of major chronic diseases.
Journal ArticleDOI

COPD Guidelines: A Review of the 2018 GOLD Report.

TL;DR: The salient features of the GOLD 2018 document are reviewed and commentary on features that merit further discussion are provided based on clinical experience and practice as well as literature review current as of February 2018.
Journal ArticleDOI

Chronic obstructive pulmonary disease in China: a nationwide prevalence study

TL;DR: The estimated overall prevalence of COPD in China in 2014–15 was 13·6%, indicating that this disease has become a major public-health problem.
References
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Journal ArticleDOI

Randomized, double-blind study comparing 5- and 7-day regimens of oral levofloxacin in patients with acute exacerbation of chronic bronchitis

TL;DR: Results show that for patients with AECB levofloxacin 500 mg once daily for 5 days provides equivalent clinical and bacteriological success to the same dose given for 7 days irrespective of the patient's age, the frequency of exacerbations or the presence of co-existing cardiopulmonary or chronic obstructive airways disease.
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Intravenous aminophylline in patients admitted to hospital with non-acidotic exacerbations of chronic obstructive pulmonary disease: a prospective randomised controlled trial

TL;DR: No evidence was found for any clinically important additional effect of aminophylline treatment when used with high dose nebulised bronchodilators and oral corticosteroids, and it cannot therefore recommend the use of intravenous aminophical treatment in the treatment of non-acidotic COPD exacerbations.
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A critical review of the effectiveness of ‘teach-back’ technique in teaching COPD patients self-management using respiratory inhalers:

TL;DR: The evidence base behind the effectiveness of the ‘teach-back’ technique as an educational intervention for chronic obstructive pulmonary disease (COPD) patient self-management using respiratory inhalers is examined.
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Phenotype of Normal Spirometry in an Aging Population

TL;DR: GLI-defined normal spirometry, even when classified as respiratory impairment by GOLD, included adjusted mean values in the normal range for multiple phenotypes, suggesting that among adults with GLI- defined normal spirometric, GOLD may misclassify normal phenotypes as having respiratory impairment.
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