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Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary

TLDR
The assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation, and the concept of de‐escalation of therapy is introduced in the treatment assessment scheme.
Abstract
This Executive Summary of the Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 Report focuses primarily on the revised and novel parts of the document. The most significant changes include: (i) the assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation. ABCD groups are now proposed to be derived exclusively from patient symptoms and their history of exacerbations; (ii) for each of the groups A to D, escalation strategies for pharmacological treatments are proposed; (iii) the concept of de-escalation of therapy is introduced in the treatment assessment scheme; (iv)non-pharmacological therapies are comprehensively presented and (v) the importance of co-morbid conditions in managing COPD is reviewed.

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Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles

TL;DR: The advantages of various drug delivery vehicles are discussed for better understanding of their utility in terms of current medical needs and the application of a wide range of nanomedicines is also described in the context of major chronic diseases.
Journal ArticleDOI

COPD Guidelines: A Review of the 2018 GOLD Report.

TL;DR: The salient features of the GOLD 2018 document are reviewed and commentary on features that merit further discussion are provided based on clinical experience and practice as well as literature review current as of February 2018.
Journal ArticleDOI

Chronic obstructive pulmonary disease in China: a nationwide prevalence study

TL;DR: The estimated overall prevalence of COPD in China in 2014–15 was 13·6%, indicating that this disease has become a major public-health problem.
References
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Journal ArticleDOI

Outcomes of Noninvasive Ventilation for Acute Exacerbations of Chronic Obstructive Pulmonary Disease in the United States, 1998–2008

TL;DR: The use of NIPPV has increased significantly over time among patients hospitalized for acute exacerbations of COPD, whereas the need for intubation and in-hospital mortality has declined, however, the rising mortality rate in a small but expanding group of patients requiring invasive mechanical ventilation after treatment with noninvasive ventilation needs further investigation.
Journal ArticleDOI

Asthma as a Risk Factor for COPD in a Longitudinal Study

TL;DR: Physician-diagnosed asthma is significantly associated with an increased risk for CB, emphysema, and COPD.
Journal ArticleDOI

Noninvasive vs. conventional mechanical ventilation in patients with chronic obstructive pulmonary disease after failure of medical treatment in the ward: a randomized trial

TL;DR: The use of NPPV in patients with chronic obstructive pulmonary disease and acute respiratory failure requiring ventilatory support after failure of medical treatment avoided ETI in 48% of the patients, had the same ICU mortality as conventional treatment and, at 1-year follow-up was associated with fewer patients readmitted to the hospital or requiring for long-term oxygen supplementation.
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