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Open AccessJournal ArticleDOI

Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary

TLDR
The assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation, and the concept of de‐escalation of therapy is introduced in the treatment assessment scheme.
Abstract
This Executive Summary of the Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 Report focuses primarily on the revised and novel parts of the document. The most significant changes include: (i) the assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation. ABCD groups are now proposed to be derived exclusively from patient symptoms and their history of exacerbations; (ii) for each of the groups A to D, escalation strategies for pharmacological treatments are proposed; (iii) the concept of de-escalation of therapy is introduced in the treatment assessment scheme; (iv)non-pharmacological therapies are comprehensively presented and (v) the importance of co-morbid conditions in managing COPD is reviewed.

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Citations
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Journal ArticleDOI

Prevalence of lung cancer in chronic obstructive pulmonary disease: A systematic review

TL;DR: Although the prevalence of lung cancer in individuals with COPD is low, it is greater than the prevalence in the general population, and knowledge of the co-occurrence of Lung cancer in COPD will inform the screening of lung cancers for patients who have COPD.
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Classification and Treatment of Chronic Obstructive Pulmonary Disease Outpatients in China According to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017: Comparison With GOLD 2014

TL;DR: Overtreatment was observed in many patients, and physicians should reexamine treatment patterns for patients reclassified into low-risk groups, as the risk of exacerbation increased with decreased BMI or education levels.
Journal ArticleDOI

Evaluation of Droplet Digital Polymerase Chain Reaction (ddPCR) for the Absolute Quantification of Aspergillus species in the Human Airway

TL;DR: In this paper, the molecular approaches of qPCR and ddPCR were applied to DNA fungal extracts in n = 20 sputum specimens obtained from non-diseased (n = 4), chronic obstructive pulmonary disease (COPD; n = 8) and non-cystic fibrosis bronchiectasis (n= 8) patients where Aspergillus status was known.
Journal ArticleDOI

Cytotoxic lymphocytes in COPD airways: increased NK cells associated with disease, iNKT and NKT-like cells with current smoking

TL;DR: Interestingly, NK cell percentages did not normalize in COPD subjects that had quit smoking, indicating that these cells might play a role in the continued disease progression seen in COPd even after smoking cessation.
Journal ArticleDOI

Qualitative and quantitative assessment of pendelluft: a simple method based on electrical impedance tomography

TL;DR: The proposed EIT-based method can be used to evaluate the degree of pendelluft in dimension of phase shift and amplitude difference and demonstrated in well-known pendellUft scenarios in 6 patients.
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The Body-Mass Index, Airflow Obstruction, Dyspnea, and Exercise Capacity Index in Chronic Obstructive Pulmonary Disease

TL;DR: The BODE index, a simple multidimensional grading system, is better than the FEV1 at predicting the risk of death from any cause and from respiratory causes among patients with COPD.
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Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease.

TL;DR: The reduction in death from all causes among patients with COPD in the combination-therapy group did not reach the predetermined level of statistical significance, and there were significant benefits in all other outcomes among these patients.
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A self-complete measure of health status for chronic airflow limitation. The St. George's Respiratory Questionnaire.

TL;DR: The St. George's Respiratory Questionnaire is a valid measure of impaired health in diseases of chronic airflow limitation that is repeatable and sensitive andMultivariate analysis demonstrated that SGRQ scores summed a number of areas of disease activity.
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