GM-CSF Controls Nonlymphoid Tissue Dendritic Cell Homeostasis but Is Dispensable for the Differentiation of Inflammatory Dendritic Cells
Melanie Greter,Julie Helft,Andrew Chow,Daigo Hashimoto,Arthur Mortha,Judith Agudo-Cantero,Milena Bogunovic,Emmanuel L. Gautier,Jennifer Miller,Marylene Leboeuf,Geming Lu,Costica Aloman,Brian D. Brown,Jeffrey W. Pollard,Huabao Xiong,Gwendalyn J. Randolph,Jerry E. Chipuk,Paul S. Frenette,Miriam Merad +18 more
TLDR
Csf-2 is important in vaccine-induced CD8(+) T cell immunity through the regulation of nonlymphoid tissue DC homeostasis rather than control of inflammatory DCs in vivo.About:
This article is published in Immunity.The article was published on 2012-06-29 and is currently open access. It has received 392 citations till now. The article focuses on the topics: Dendritic cell homeostasis & CD8.read more
Citations
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The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting.
TL;DR: This review discusses major advances in the understanding of the regulation of DC lineage commitment, differentiation, diversification, and function in situ.
Journal ArticleDOI
Microglia emerge as central players in brain disease.
Michael W. Salter,Beth Stevens +1 more
TL;DR: Recent developments in the rapidly expanding understanding of the function, as well as the dysfunction, of microglia in disorders of the CNS are focused on.
Journal ArticleDOI
Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF
Martin Guilliams,Martin Guilliams,Ismé de Kleer,Ismé de Kleer,Sandrine Henri,Sijranke Post,Leen Vanhoutte,Leen Vanhoutte,Sofie De Prijck,Kim Deswarte,Bernard Malissen,Hamida Hammad,Bart N. Lambrecht,Bart N. Lambrecht +13 more
TL;DR: Alveolar macrophages differentiate from fetal monocytes in a GM-CSF–dependent fashion and colonize the alveolar space within a few days after birth.
Human CD141(+) (BDCA-3)(+) dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens
Sarah L. Jongbloed,Andrew J. Kassianos,Kylie J. McDonald,Georgina J. Clark,Xinsheng Ju,Catherine E. Angel,Chun-Jen J. Chen,P. Rod Dunbar,Robert Wadley,Varinder Jeet,Annelie J.E. Vulink,Derek N.J. Hart,Derek N.J. Hart,Kristen J. Radford +13 more
TL;DR: The data demonstrate a role for CD141+ DCs in the induction of cytotoxic T lymphocyte responses and suggest that they may be the most relevant targets for vaccination against cancers, viruses, and other pathogens.
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Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis.
Arthur Mortha,Aleksey Chudnovskiy,Daigo Hashimoto,Milena Bogunovic,Sean P. Spencer,Yasmine Belkaid,Miriam Merad +6 more
TL;DR: The cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF), recently renamed Csf2, is a key determinant of myeloid lineage differentiation and is required for the optimal function of tissue MNPs.
References
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Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.
TL;DR: Cultured DCs are as efficient as antigen-specific B cells in presenting tetanus toxoid (TT) to specific T cell clones and their efficiency of antigen presentation can be further enhanced by specific antibodies via FcR- mediated antigen uptake.
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Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Florent Ginhoux,Florent Ginhoux,Melanie Greter,Marylene Leboeuf,Sayan Nandi,Peter See,Solen Gokhan,Mark F. Mehler,Simon J. Conway,Lai Guan Ng,E. Richard Stanley,Igor M. Samokhvalov,Miriam Merad +12 more
TL;DR: Results identify microglia as an ontogenically distinct population in the mononuclear phagocyte system and have implications for the use of embryonically derived microglial progenitors for the treatment of various brain disorders.
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Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.
K Inaba,M Inaba,Nikolaus Romani,H Aya,Masashi Deguchi,Susumu Ikehara,Shigeru Muramatsu,Ralph M. Steinman +7 more
TL;DR: The methodology for inducing dendritic cell growth that was recently described for mouse blood now has been modified to MHC class II- negative precursors in marrow, and this feature should prove useful for future molecular and clinical studies of this otherwise trace cell type.
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Batf3 Deficiency Reveals a Critical Role for CD8α+ Dendritic Cells in Cytotoxic T Cell Immunity
Kai Hildner,Brian T. Edelson,Whitney E. Purtha,Mark S Diamond,Hirokazu Matsushita,Masako Kohyama,Boris Calderon,Barbara U. Schraml,Emil R. Unanue,Michael S. Diamond,Robert D. Schreiber,Theresa L. Murphy,Kenneth M. Murphy +12 more
TL;DR: An important role is suggested for CD8α+ dendritic cells and cross-presentation in responses to viruses and in tumor rejection in Batf3–/– mice.
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Steady-state and inflammatory dendritic-cell development
Ken Shortman,Shalin H. Naik +1 more
TL;DR: These studies show that many individual tissues generate their own DCs locally, from a reservoir of immediate DC precursors, rather than depending on a continuous flux of DCs from the bone marrow.