Journal ArticleDOI
Graphene Quantum Dots-Capped Magnetic Mesoporous Silica Nanoparticles as a Multifunctional Platform for Controlled Drug Delivery, Magnetic Hyperthermia, and Photothermal Therapy.
TLDR
The results indicate that compared with chemotherapy, magnetichyperthermia or photothermal therapy alone, the combined chemo-magnetic hyperthermia therapy or chemo -photothermal therapy with the DOX-loaded MMSN/GQDs nanosystem exhibits a significant synergistic effect, resulting in a higher efficacy to kill cancer cells.Abstract:Â
A multifunctional platform is reported for synergistic therapy with controlled drug release, magnetic hyperthermia, and photothermal therapy, which is composed of graphene quantum dots (GQDs) as caps and local photothermal generators and magnetic mesoporous silica nanoparticles (MMSN) as drug carriers and magnetic thermoseeds. The structure, drug release behavior, magnetic hyperthermia capacity, photothermal effect, and synergistic therapeutic efficiency of the MMSN/GQDs nanoparticles are investigated. The results show that monodisperse MMSN/GQDs nanoparticles with the particle size of 100 nm can load doxorubicin (DOX) and trigger DOX release by low pH environment. Furthermore, the MMSN/GQDs nanoparticles can efficiently generate heat to the hyperthermia temperature under an alternating magnetic field or by near infrared irradiation. More importantly, breast cancer 4T1 cells as a model cellular system, the results indicate that compared with chemotherapy, magnetic hyperthermia or photothermal therapy alone, the combined chemo-magnetic hyperthermia therapy or chemo-photothermal therapy with the DOX-loaded MMSN/GQDs nanosystem exhibits a significant synergistic effect, resulting in a higher efficacy to kill cancer cells. Therefore, the MMSN/GQDs multifunctional platform has great potential in cancer therapy for enhancing the therapeutic efficiency.read more
Citations
More filters
Journal ArticleDOI
Water-soluble ferrocene complexes (WFCs) functionalized silica nanospheres for WFC delivery in HepG2 tumor therapy.
TL;DR: The novel nanocarrier system for WFC delivery present a novel concept-of-proof method to protect varieties of affordable metal-based anticancer agents in physiological conditions and provided experimental basis for future studies focusing on drug delivery of other WFCs.
Journal ArticleDOI
Physically stimulus-responsive nanoparticles for therapy and diagnosis
Fatemeh Farjadian,Soheila Ghasemi,Mohsen Akbarian,Mojtaba Hoseini-Ghahfarokhi,Mohsen Moghoofei,Mohammad Doroudian +5 more
TL;DR: This review focuses on physically triggered nano-systems (PTNSs), with diagnostic or therapeutic and theranostic applications, based on polymeric micelles and hydrogels, mesoporous silica, and magnets.
Journal ArticleDOI
Iron oxide nanoparticles for theranostic applications - Recent advances
TL;DR: In this paper , a review summarizes the recent advances in the use of iron oxide nanoparticles in various applications such as magnetic resonance imaging (MRI), magnetically activated cell sorting, magnetic biosensors, magnetic hyperthermia, drug delivery, radioimmunotherapy, magnetofection and ferrotherapy in detail.
Journal ArticleDOI
Multifunctional MoS2 composite nanomaterials for drug delivery and synergistic photothermal therapy in cancer treatment
TL;DR: In this paper , a novel MoS 2 composite nanosheets material with lamellar structure and good water solubility (BBPL-MoS 2 -LP) was synthesized, which had high photothermal conversion efficiency and good biocompatibility.
References
More filters
Journal ArticleDOI
A mesoporous silica nanosphere-based carrier system with chemically removable CdS nanoparticle caps for stimuli-responsive controlled release of neurotransmitters and drug molecules.
Cheng-Yu Lai,Brian G. Trewyn,Dusan M. Jeftinija,Ksenija Jeftinija,Shu Xu,Srdija Jeftinija,Victor S.-Y. Lin +6 more
TL;DR: An MCM-41 type mesoporous silica nanosphere-based controlled-release delivery system has been synthesized and characterized using surface-derivatized cadmium sulfide nanocrystals as chemically removable caps to encapsulate several pharmaceutical drug molecules and neurotransmitters inside the organically functionalized MSN Mesoporous framework.
Journal ArticleDOI
Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery
TL;DR: Potential opportunities for the combination of hyperthermia-based therapy and controlled drug release paradigms--towards successful application in personalized medicine are portrayed.
Journal ArticleDOI
Functionalized mesoporous silica materials for controlled drug delivery
TL;DR: This review highlights the most recent research progress on silica-based controlled drug delivery systems, including pure mesoporous silica sustained-release systems, magnetism and/or luminescence functionalized mesoporus silica systems which integrate targeting and tracking abilities of drug molecules.
Journal ArticleDOI
Unusual infrared-absorption mechanism in thermally reduced graphene oxide
Muge Acik,Geunsik Lee,Cecilia Mattevi,Cecilia Mattevi,Manish Chhowalla,Manish Chhowalla,Kyeongjae Cho,Yves J. Chabal +7 more
TL;DR: The observation of a giant-infrared-absorption band in reduced graphene oxide is reported, arising from the coupling of electronic states to the asymmetric stretch mode of a yet-unreported structure, consisting of oxygen atoms aggregated at the edges of defects.
Journal ArticleDOI
Multifunctional Mesoporous Silica-Coated Graphene Nanosheet Used for Chemo-Photothermal Synergistic Targeted Therapy of Glioma
TL;DR: These findings provided an excellent drug delivery system for combined therapy of glioma due to the advanced chemo-photothermal synergistic targeted therapy and good drug release properties of GSPID, which could effectively avoid frequent and invasive dosing and improve patient compliance.