Journal ArticleDOI
Graphene Quantum Dots-Capped Magnetic Mesoporous Silica Nanoparticles as a Multifunctional Platform for Controlled Drug Delivery, Magnetic Hyperthermia, and Photothermal Therapy.
TLDR
The results indicate that compared with chemotherapy, magnetichyperthermia or photothermal therapy alone, the combined chemo-magnetic hyperthermia therapy or chemo -photothermal therapy with the DOX-loaded MMSN/GQDs nanosystem exhibits a significant synergistic effect, resulting in a higher efficacy to kill cancer cells.Abstract:
A multifunctional platform is reported for synergistic therapy with controlled drug release, magnetic hyperthermia, and photothermal therapy, which is composed of graphene quantum dots (GQDs) as caps and local photothermal generators and magnetic mesoporous silica nanoparticles (MMSN) as drug carriers and magnetic thermoseeds. The structure, drug release behavior, magnetic hyperthermia capacity, photothermal effect, and synergistic therapeutic efficiency of the MMSN/GQDs nanoparticles are investigated. The results show that monodisperse MMSN/GQDs nanoparticles with the particle size of 100 nm can load doxorubicin (DOX) and trigger DOX release by low pH environment. Furthermore, the MMSN/GQDs nanoparticles can efficiently generate heat to the hyperthermia temperature under an alternating magnetic field or by near infrared irradiation. More importantly, breast cancer 4T1 cells as a model cellular system, the results indicate that compared with chemotherapy, magnetic hyperthermia or photothermal therapy alone, the combined chemo-magnetic hyperthermia therapy or chemo-photothermal therapy with the DOX-loaded MMSN/GQDs nanosystem exhibits a significant synergistic effect, resulting in a higher efficacy to kill cancer cells. Therefore, the MMSN/GQDs multifunctional platform has great potential in cancer therapy for enhancing the therapeutic efficiency.read more
Citations
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Iridium oxide nanoparticles-based theranostic probe for in vivo tumor imaging and synergistic chem/photothermal treatments of cancer cells
TL;DR: In this article , a novel iridium oxide nanoparticles-based probe was developed for in vivo fluorescence imaging of microRNA and synergistic chem/photothermal treatments of tumor.
Journal ArticleDOI
From Materials to Devices: Graphene toward Practical Applications
TL;DR: Graphene has made a great progress in the development of flexible electronics since its discovery in 2004 as discussed by the authors , and has been playing an important role in flexible electronics, such as sensors, microphones, sound source, electrophysiological detection, solar cells, synaptic transistors, light-emitting devices, and so on.
Journal ArticleDOI
Multifunctional Nanoplatform Based on pH-responsive Micelle Coated with Discontinuous Gold Shell for Cancer Photothermo-chemotherapy and Photoacoustic Tomography
TL;DR: In this study, a pH-sensitive diblock copolymer poly(aspartic acid-butanediamine)-poly(2-(diisopropylamino)ethyl methacrylate) (PAsp(DAB)-PDPA) was synthesized and self-assembled into doxorubicin-loaded micelle, which was further used as a template to form a gold nanoshell to facilitate photothermal therapy.
Journal ArticleDOI
Glucose-Responsive Enzyme-Controlled Mesoporous Nanomachine with a Layer-by-Layer Supramolecular Architecture
Sandra Jimenez-Falcao,Beatriz de Luis,Alba García-Fernández,Antoni Llopis-Lorente,Paula Díez,Alfredo Sánchez,Félix Sancenón,Paloma Martínez-Ruiz,Ramón Martínez-Máñez,Reynaldo Villalonga +9 more
TL;DR: In this article, an integrated and pH-sensitive nanomachine with layer-by-layer supramolecular design and enzymatic control for on-command delivery is described.
Journal ArticleDOI
Synthesis and characterization of amine-functionalized Fe3O4/Mesoporous Silica Nanoparticles (MSNs) as potential nanocarriers in drug delivery systems
Hamed Ghasemi Tabasi,Mohammad Taghi Hamed Mosavian,Majid Darroudi,Majid Khazaei,Alireza Hashemzadeh,Zahra Sabouri +5 more
TL;DR: In this paper , the structure and morphology of the as-synthesized superparamagnetic iron oxide nanoparticles have been characterized by the usage of different analyzing methods such as XRD, FTIR, TEM, FE-SEM, and TGA.
References
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A mesoporous silica nanosphere-based carrier system with chemically removable CdS nanoparticle caps for stimuli-responsive controlled release of neurotransmitters and drug molecules.
Cheng-Yu Lai,Brian G. Trewyn,Dusan M. Jeftinija,Ksenija Jeftinija,Shu Xu,Srdija Jeftinija,Victor S.-Y. Lin +6 more
TL;DR: An MCM-41 type mesoporous silica nanosphere-based controlled-release delivery system has been synthesized and characterized using surface-derivatized cadmium sulfide nanocrystals as chemically removable caps to encapsulate several pharmaceutical drug molecules and neurotransmitters inside the organically functionalized MSN Mesoporous framework.
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Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery
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Functionalized mesoporous silica materials for controlled drug delivery
TL;DR: This review highlights the most recent research progress on silica-based controlled drug delivery systems, including pure mesoporous silica sustained-release systems, magnetism and/or luminescence functionalized mesoporus silica systems which integrate targeting and tracking abilities of drug molecules.
Journal ArticleDOI
Unusual infrared-absorption mechanism in thermally reduced graphene oxide
Muge Acik,Geunsik Lee,Cecilia Mattevi,Cecilia Mattevi,Manish Chhowalla,Manish Chhowalla,Kyeongjae Cho,Yves J. Chabal +7 more
TL;DR: The observation of a giant-infrared-absorption band in reduced graphene oxide is reported, arising from the coupling of electronic states to the asymmetric stretch mode of a yet-unreported structure, consisting of oxygen atoms aggregated at the edges of defects.
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Multifunctional Mesoporous Silica-Coated Graphene Nanosheet Used for Chemo-Photothermal Synergistic Targeted Therapy of Glioma
TL;DR: These findings provided an excellent drug delivery system for combined therapy of glioma due to the advanced chemo-photothermal synergistic targeted therapy and good drug release properties of GSPID, which could effectively avoid frequent and invasive dosing and improve patient compliance.