Journal ArticleDOI
Graphene Quantum Dots-Capped Magnetic Mesoporous Silica Nanoparticles as a Multifunctional Platform for Controlled Drug Delivery, Magnetic Hyperthermia, and Photothermal Therapy.
TLDR
The results indicate that compared with chemotherapy, magnetichyperthermia or photothermal therapy alone, the combined chemo-magnetic hyperthermia therapy or chemo -photothermal therapy with the DOX-loaded MMSN/GQDs nanosystem exhibits a significant synergistic effect, resulting in a higher efficacy to kill cancer cells.Abstract:
A multifunctional platform is reported for synergistic therapy with controlled drug release, magnetic hyperthermia, and photothermal therapy, which is composed of graphene quantum dots (GQDs) as caps and local photothermal generators and magnetic mesoporous silica nanoparticles (MMSN) as drug carriers and magnetic thermoseeds. The structure, drug release behavior, magnetic hyperthermia capacity, photothermal effect, and synergistic therapeutic efficiency of the MMSN/GQDs nanoparticles are investigated. The results show that monodisperse MMSN/GQDs nanoparticles with the particle size of 100 nm can load doxorubicin (DOX) and trigger DOX release by low pH environment. Furthermore, the MMSN/GQDs nanoparticles can efficiently generate heat to the hyperthermia temperature under an alternating magnetic field or by near infrared irradiation. More importantly, breast cancer 4T1 cells as a model cellular system, the results indicate that compared with chemotherapy, magnetic hyperthermia or photothermal therapy alone, the combined chemo-magnetic hyperthermia therapy or chemo-photothermal therapy with the DOX-loaded MMSN/GQDs nanosystem exhibits a significant synergistic effect, resulting in a higher efficacy to kill cancer cells. Therefore, the MMSN/GQDs multifunctional platform has great potential in cancer therapy for enhancing the therapeutic efficiency.read more
Citations
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Controlling Morphology and Release Behavior of Sorafenib-Loaded Nanocarriers Prepared by Flash Nanoprecipitation
Mingwei Wang,Shan Lin,Junyou Wang,Lei Liu,Wenjuan Zhou,Rizwan Bhutto Ahmed,Aiguo Hu,Xuhong Guo,Xuhong Guo,Martien A. Cohen Stuart +9 more
TL;DR: This work prepared stable sorafenib-loaded NPs with biocompatible amphiphilic poly(ethylene glycol)-block-poly(lactide acid) (PEG-b-PLA) as stabilizing polymer based on FNP to show well-controlled size and high drug loading content compared with nanoparticles from traditional antisolvent precipitation.
Journal ArticleDOI
Preparation of organic-modified magadiite–magnetic nanocomposite particles as an effective nanohybrid drug carrier material for cancer treatment and its properties of sustained release mechanism by Korsmeyer–Peppas kinetic model
Mingliang Ge,Mingliang Ge,Mingliang Ge,Yueying Li,Caiping Zhu,Guodong Liang,Jahangir Alam S.M.,Guoqing Hu,Yuee Gui,Junaebur Rashid M. +9 more
TL;DR: In this paper, the nanoparticles Fe3O4 were supported on cetyltrimethyl ammonium-bromide (CTAB)-modified magadiite by coprecipitation method to prepare magnetic composite particles, which exhibited high drug loading capacity up to 123.98 mg/g of binding anticancer drug 5-fluorouracil (5-FU).
Journal ArticleDOI
Functionalized graphene oxide/Fe3O4 nanocomposite: A biocompatible and robust nanocarrier for targeted delivery and release of anticancer agents.
Asghar Taheri-Kafrani,Hamidreza Shirzadfar,Abolghasem Abbasi Kajani,Bassam K. Kudhair,Layth Jasim Mohammed,Shima Mohammadi,Fatemeh Lotfi +6 more
TL;DR: In this paper, a simple approach was used for the synthesis of superparamagnetic graphene oxide (SPMGO) nanocomposite through a chemical precipitation method, which was readily functionalized with cyanuric chloride as a linker for loading the drug.
Journal ArticleDOI
Magnetic Particle Bioconjugates: A Versatile Sensor Approach
TL;DR: In this article, the authors highlight the evergrowing applications of magnetic materials for the detection of analytes present in various real sample matrices, and show the versatility and advantages of using magnetic particles for a variety of sample matrix and analyte types and the adaptability of different transducers with the magnetic particle approaches.
Journal ArticleDOI
Were magnetic materials useful in cancer therapy
TL;DR: Magnetic nanoparticles have been also designed for utilizing as contrast enhancer agents for magnetic resonance imaging, drug delivery systems, and most recently as a therapeutic element in inducing cellular death in tumor ablation therapies.
References
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A mesoporous silica nanosphere-based carrier system with chemically removable CdS nanoparticle caps for stimuli-responsive controlled release of neurotransmitters and drug molecules.
Cheng-Yu Lai,Brian G. Trewyn,Dusan M. Jeftinija,Ksenija Jeftinija,Shu Xu,Srdija Jeftinija,Victor S.-Y. Lin +6 more
TL;DR: An MCM-41 type mesoporous silica nanosphere-based controlled-release delivery system has been synthesized and characterized using surface-derivatized cadmium sulfide nanocrystals as chemically removable caps to encapsulate several pharmaceutical drug molecules and neurotransmitters inside the organically functionalized MSN Mesoporous framework.
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Functionalized mesoporous silica materials for controlled drug delivery
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Journal ArticleDOI
Unusual infrared-absorption mechanism in thermally reduced graphene oxide
Muge Acik,Geunsik Lee,Cecilia Mattevi,Cecilia Mattevi,Manish Chhowalla,Manish Chhowalla,Kyeongjae Cho,Yves J. Chabal +7 more
TL;DR: The observation of a giant-infrared-absorption band in reduced graphene oxide is reported, arising from the coupling of electronic states to the asymmetric stretch mode of a yet-unreported structure, consisting of oxygen atoms aggregated at the edges of defects.
Journal ArticleDOI
Multifunctional Mesoporous Silica-Coated Graphene Nanosheet Used for Chemo-Photothermal Synergistic Targeted Therapy of Glioma
TL;DR: These findings provided an excellent drug delivery system for combined therapy of glioma due to the advanced chemo-photothermal synergistic targeted therapy and good drug release properties of GSPID, which could effectively avoid frequent and invasive dosing and improve patient compliance.