Journal ArticleDOI
Graphene Quantum Dots-Capped Magnetic Mesoporous Silica Nanoparticles as a Multifunctional Platform for Controlled Drug Delivery, Magnetic Hyperthermia, and Photothermal Therapy.
TLDR
The results indicate that compared with chemotherapy, magnetichyperthermia or photothermal therapy alone, the combined chemo-magnetic hyperthermia therapy or chemo -photothermal therapy with the DOX-loaded MMSN/GQDs nanosystem exhibits a significant synergistic effect, resulting in a higher efficacy to kill cancer cells.Abstract:
A multifunctional platform is reported for synergistic therapy with controlled drug release, magnetic hyperthermia, and photothermal therapy, which is composed of graphene quantum dots (GQDs) as caps and local photothermal generators and magnetic mesoporous silica nanoparticles (MMSN) as drug carriers and magnetic thermoseeds. The structure, drug release behavior, magnetic hyperthermia capacity, photothermal effect, and synergistic therapeutic efficiency of the MMSN/GQDs nanoparticles are investigated. The results show that monodisperse MMSN/GQDs nanoparticles with the particle size of 100 nm can load doxorubicin (DOX) and trigger DOX release by low pH environment. Furthermore, the MMSN/GQDs nanoparticles can efficiently generate heat to the hyperthermia temperature under an alternating magnetic field or by near infrared irradiation. More importantly, breast cancer 4T1 cells as a model cellular system, the results indicate that compared with chemotherapy, magnetic hyperthermia or photothermal therapy alone, the combined chemo-magnetic hyperthermia therapy or chemo-photothermal therapy with the DOX-loaded MMSN/GQDs nanosystem exhibits a significant synergistic effect, resulting in a higher efficacy to kill cancer cells. Therefore, the MMSN/GQDs multifunctional platform has great potential in cancer therapy for enhancing the therapeutic efficiency.read more
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Prussian blue decorated mesoporous silica hybrid nanocarriers for photoacoustic imaging-guided synergistic chemo-photothermal combination therapy
Madhappan Santha Moorthy,Giang Hoang,Bharathiraja Subramanian,Nhat Quang Bui,Manivasagan Panchanathan,Sudip Mondal,Vy Phan Thi Tuong,Hyehyun Kim,Junghwan Oh +8 more
TL;DR: The Prussian blue nanoflake (PBNF) decorated mesoporous silica hybrid nanoparticle (PB@MSH-EDA NPs) system could be utilized as an efficient PAI-guided chemo-photothermal therapy agent for the detection and treatment of tumors in an emerging cancer therapy application.
Journal ArticleDOI
Synthesis of near-infrared responsive gold nanorod-doped gelatin/hydroxyapatite composite microspheres with controlled photo-thermal property
TL;DR: In this paper, a gelatin/hydroxyapatatite (HAp) composite microspheres with photo-thermal properties was synthesized via an emulsion technique and their microstructure and NIR-responsive photothermal property were investigated.
Journal ArticleDOI
A chloroquine-loaded Prussian blue platform with controllable autophagy inhibition for enhanced photothermal therapy.
Yan Ma,Huajian Chen,Bai-Mei Hao,Junhong Zhou,Gang He,Zhaohua Miao,Yan Xu,Li Gao,Wei Zhou,Zhengbao Zha +9 more
TL;DR: This work is expected to depict an effective strategy for the design and construction of a thermally responsive CQ delivery platform for modulating autophagy inhibition in tumors to reinforce the efficacy of photothermal therapy (PTT).
Journal ArticleDOI
From proof-of-concept material to PEGylated and modularly targeted ultrasound-responsive mesoporous silica nanoparticles
TL;DR: In this paper, the authors present the synthesis, characterization and in vitro biological evaluation of PEGylated and actively-targeted ultrasound-responsive hybrid mesoporous silica nanoparticles.
Journal ArticleDOI
Graphene quantum dots-decorated hollow copper sulfide nanoparticles for controlled intracellular drug release and enhanced photothermal-chemotherapy
Shaohui Zheng,Shaohui Zheng,Zhen Jin,Cuiping Han,Jingjing Li,Hang Xu,Sukho Park,Jong-Oh Park,Eunpyo Choi,Kai Xu +9 more
TL;DR: The prepared DOX-CuS@GQDs NPs provided a novel promising platform for cancer therapy with controlled intracellular drug release and combined photothermal-chemotherapy.
References
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A mesoporous silica nanosphere-based carrier system with chemically removable CdS nanoparticle caps for stimuli-responsive controlled release of neurotransmitters and drug molecules.
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Multifunctional Mesoporous Silica-Coated Graphene Nanosheet Used for Chemo-Photothermal Synergistic Targeted Therapy of Glioma
TL;DR: These findings provided an excellent drug delivery system for combined therapy of glioma due to the advanced chemo-photothermal synergistic targeted therapy and good drug release properties of GSPID, which could effectively avoid frequent and invasive dosing and improve patient compliance.