Journal ArticleDOI
Graphene Quantum Dots-Capped Magnetic Mesoporous Silica Nanoparticles as a Multifunctional Platform for Controlled Drug Delivery, Magnetic Hyperthermia, and Photothermal Therapy.
TLDR
The results indicate that compared with chemotherapy, magnetichyperthermia or photothermal therapy alone, the combined chemo-magnetic hyperthermia therapy or chemo -photothermal therapy with the DOX-loaded MMSN/GQDs nanosystem exhibits a significant synergistic effect, resulting in a higher efficacy to kill cancer cells.Abstract:
A multifunctional platform is reported for synergistic therapy with controlled drug release, magnetic hyperthermia, and photothermal therapy, which is composed of graphene quantum dots (GQDs) as caps and local photothermal generators and magnetic mesoporous silica nanoparticles (MMSN) as drug carriers and magnetic thermoseeds. The structure, drug release behavior, magnetic hyperthermia capacity, photothermal effect, and synergistic therapeutic efficiency of the MMSN/GQDs nanoparticles are investigated. The results show that monodisperse MMSN/GQDs nanoparticles with the particle size of 100 nm can load doxorubicin (DOX) and trigger DOX release by low pH environment. Furthermore, the MMSN/GQDs nanoparticles can efficiently generate heat to the hyperthermia temperature under an alternating magnetic field or by near infrared irradiation. More importantly, breast cancer 4T1 cells as a model cellular system, the results indicate that compared with chemotherapy, magnetic hyperthermia or photothermal therapy alone, the combined chemo-magnetic hyperthermia therapy or chemo-photothermal therapy with the DOX-loaded MMSN/GQDs nanosystem exhibits a significant synergistic effect, resulting in a higher efficacy to kill cancer cells. Therefore, the MMSN/GQDs multifunctional platform has great potential in cancer therapy for enhancing the therapeutic efficiency.read more
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Recent Advances in Functional‐Polymer‐Decorated Transition‐Metal Nanomaterials for Bioimaging and Cancer Therapy
TL;DR: This review focuses on recent advances in the synthesis of polymer‐functionalized transition‐metal‐based nanomaterials and follows this up by discussing their applications in bioimaging diagnosis and cancer therapy.
Journal ArticleDOI
ROS self-generation and hypoxia self-enhanced biodegradable magnetic nanotheranostics for targeted tumor therapy
TL;DR: A new nanostructure based on biodegradable mesoporous magnetic nanocubes (MMNCs) is designed for ROS self-generation and self-enhancement magnetic thermotherapy, which highlights the great potential of Vc loaded magnetic nanoparticle composites as efficient agents for tumor therapy.
Journal ArticleDOI
Construction of Urokinase-Type Plasminogen Activator Receptor-Targeted Heterostructures for Efficient Photothermal Chemotherapy against Cervical Cancer To Achieve Simultaneous Anticancer and Antiangiogenesis
Xiaoli Hu,Chetry Mandika,Lizhen He,Yuanyuan You,Yanzhou Chang,Jing Wang,Tianfeng Chen,Tianfeng Chen,Xueqiong Zhu +8 more
TL;DR: This study fabricate a cervical cancer-targeting gold nanorod-mesoporous silica heterostructure for co-delivery of synergistic cisplatin and antiangiogenic drug Avastin to achieve synergistic chemo-photothermal therapy and contributes to the development of the clinical translation of nanomedicines.
Journal ArticleDOI
Multifunctional Fe3O4@Au supraparticle as a promising thermal contrast for an ultrasensitive lateral flow immunoassay.
TL;DR: The photothermal LFIA renders a rapid, sensitive, and quantitative bio-/chemo-sensing platform with only a portable laser source and a thermal camera for quantitative Ochratoxin A (OTA) detection.
References
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A mesoporous silica nanosphere-based carrier system with chemically removable CdS nanoparticle caps for stimuli-responsive controlled release of neurotransmitters and drug molecules.
Cheng-Yu Lai,Brian G. Trewyn,Dusan M. Jeftinija,Ksenija Jeftinija,Shu Xu,Srdija Jeftinija,Victor S.-Y. Lin +6 more
TL;DR: An MCM-41 type mesoporous silica nanosphere-based controlled-release delivery system has been synthesized and characterized using surface-derivatized cadmium sulfide nanocrystals as chemically removable caps to encapsulate several pharmaceutical drug molecules and neurotransmitters inside the organically functionalized MSN Mesoporous framework.
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Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery
TL;DR: Potential opportunities for the combination of hyperthermia-based therapy and controlled drug release paradigms--towards successful application in personalized medicine are portrayed.
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Functionalized mesoporous silica materials for controlled drug delivery
TL;DR: This review highlights the most recent research progress on silica-based controlled drug delivery systems, including pure mesoporous silica sustained-release systems, magnetism and/or luminescence functionalized mesoporus silica systems which integrate targeting and tracking abilities of drug molecules.
Journal ArticleDOI
Unusual infrared-absorption mechanism in thermally reduced graphene oxide
Muge Acik,Geunsik Lee,Cecilia Mattevi,Cecilia Mattevi,Manish Chhowalla,Manish Chhowalla,Kyeongjae Cho,Yves J. Chabal +7 more
TL;DR: The observation of a giant-infrared-absorption band in reduced graphene oxide is reported, arising from the coupling of electronic states to the asymmetric stretch mode of a yet-unreported structure, consisting of oxygen atoms aggregated at the edges of defects.
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Multifunctional Mesoporous Silica-Coated Graphene Nanosheet Used for Chemo-Photothermal Synergistic Targeted Therapy of Glioma
TL;DR: These findings provided an excellent drug delivery system for combined therapy of glioma due to the advanced chemo-photothermal synergistic targeted therapy and good drug release properties of GSPID, which could effectively avoid frequent and invasive dosing and improve patient compliance.