Journal ArticleDOI
Graphene Quantum Dots-Capped Magnetic Mesoporous Silica Nanoparticles as a Multifunctional Platform for Controlled Drug Delivery, Magnetic Hyperthermia, and Photothermal Therapy.
TLDR
The results indicate that compared with chemotherapy, magnetichyperthermia or photothermal therapy alone, the combined chemo-magnetic hyperthermia therapy or chemo -photothermal therapy with the DOX-loaded MMSN/GQDs nanosystem exhibits a significant synergistic effect, resulting in a higher efficacy to kill cancer cells.Abstract:
A multifunctional platform is reported for synergistic therapy with controlled drug release, magnetic hyperthermia, and photothermal therapy, which is composed of graphene quantum dots (GQDs) as caps and local photothermal generators and magnetic mesoporous silica nanoparticles (MMSN) as drug carriers and magnetic thermoseeds. The structure, drug release behavior, magnetic hyperthermia capacity, photothermal effect, and synergistic therapeutic efficiency of the MMSN/GQDs nanoparticles are investigated. The results show that monodisperse MMSN/GQDs nanoparticles with the particle size of 100 nm can load doxorubicin (DOX) and trigger DOX release by low pH environment. Furthermore, the MMSN/GQDs nanoparticles can efficiently generate heat to the hyperthermia temperature under an alternating magnetic field or by near infrared irradiation. More importantly, breast cancer 4T1 cells as a model cellular system, the results indicate that compared with chemotherapy, magnetic hyperthermia or photothermal therapy alone, the combined chemo-magnetic hyperthermia therapy or chemo-photothermal therapy with the DOX-loaded MMSN/GQDs nanosystem exhibits a significant synergistic effect, resulting in a higher efficacy to kill cancer cells. Therefore, the MMSN/GQDs multifunctional platform has great potential in cancer therapy for enhancing the therapeutic efficiency.read more
Citations
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A review on graphene quantum dots and their nanocomposites: from laboratory synthesis towards agricultural and environmental applications
Murilo H.M. Facure,Murilo H.M. Facure,Rodrigo Schneider,Rodrigo Schneider,Luiza A. Mercante,Daniel S. Correa,Daniel S. Correa +6 more
TL;DR: Graphene quantum dots (GQDs) are 0D materials belonging to the carbon-based family that present some interesting characteristics of graphene combined with a tunable bandgap emerging from their reduced size.
Journal ArticleDOI
Principles of Magnetic Hyperthermia: A Focus on Using Multifunctional Hybrid Magnetic Nanoparticles
Ihab M. Obaidat,Venkatesha Narayanaswamy,Sulaiman Alaabed,Sangaraju Sambasivam,Chandu V. V. Muralee Gopi +4 more
TL;DR: Light is shed on the principles of heat generation by MNPs in AMF, the limitations and challenges of MH, and the applications of MH using multifunctional hybrid MNPs.
Journal ArticleDOI
Highly efficient cascading synergy of cancer photo-immunotherapy enabled by engineered graphene quantum dots/photosensitizer/CpG oligonucleotides hybrid nanotheranostics.
Chunhui Wu,Xiaotian Guan,Jiming Xu,Yingxue Zhang,Qiuyue Liu,Yuan Tian,Shun Li,Xiang Qin,Hong Yang,Yiyao Liu,Yiyao Liu +10 more
TL;DR: A new type of versatile nanoassemblies was rationally designed by integrating the polydopamine stabilized graphene quantum dots-photosensitizer nanocomposites, and achieved robust inhibition efficiency to almost completely suppress the EMT6 murine mammary cancer model under laser irradiation implying the superior synergy of combined photoimmunotherapy.
Journal ArticleDOI
Synergic effects of nanoparticles-mediated hyperthermia in radiotherapy/chemotherapy of cancer.
Keywan Mortezaee,Asghar Narmani,Majid Salehi,Hamed Bagheri,Bagher Farhood,Hamed Haghi-Aminjan,Masoud Najafi +6 more
TL;DR: In this paper, the authors summarized the principles of NPs-induced hyperthermia and more importantly its synergic effects on the conventional chemotherapy or radiotherapy, as well as the non-heat-producing nanostructures such as lipid-based, polymeric, and silica-based NPs, as the carrier for heat-producing NPs.
Journal ArticleDOI
Glass-ceramics for cancer treatment: So close, or yet so far?
Marta Miola,Yousef Pakzad,Sara Banijamali,Saeid Kargozar,Chiara Vitale-Brovarone,Abolfazl Yazdanpanah,Oana Bretcanu,Arash Ramedani,Arash Ramedani,Enrica Verne,Masoud Mozafari +10 more
TL;DR: The current state-of-the-art glass-ceramics for cancer treatment is reviewed, starting with current products and moving onto recent developments in this field, to better answer the critical questions essential for clinical usage.
References
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Multifunctional Mesoporous Silica-Coated Graphene Nanosheet Used for Chemo-Photothermal Synergistic Targeted Therapy of Glioma
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