Journal ArticleDOI
Graphene Quantum Dots-Capped Magnetic Mesoporous Silica Nanoparticles as a Multifunctional Platform for Controlled Drug Delivery, Magnetic Hyperthermia, and Photothermal Therapy.
TLDR
The results indicate that compared with chemotherapy, magnetichyperthermia or photothermal therapy alone, the combined chemo-magnetic hyperthermia therapy or chemo -photothermal therapy with the DOX-loaded MMSN/GQDs nanosystem exhibits a significant synergistic effect, resulting in a higher efficacy to kill cancer cells.Abstract:
A multifunctional platform is reported for synergistic therapy with controlled drug release, magnetic hyperthermia, and photothermal therapy, which is composed of graphene quantum dots (GQDs) as caps and local photothermal generators and magnetic mesoporous silica nanoparticles (MMSN) as drug carriers and magnetic thermoseeds. The structure, drug release behavior, magnetic hyperthermia capacity, photothermal effect, and synergistic therapeutic efficiency of the MMSN/GQDs nanoparticles are investigated. The results show that monodisperse MMSN/GQDs nanoparticles with the particle size of 100 nm can load doxorubicin (DOX) and trigger DOX release by low pH environment. Furthermore, the MMSN/GQDs nanoparticles can efficiently generate heat to the hyperthermia temperature under an alternating magnetic field or by near infrared irradiation. More importantly, breast cancer 4T1 cells as a model cellular system, the results indicate that compared with chemotherapy, magnetic hyperthermia or photothermal therapy alone, the combined chemo-magnetic hyperthermia therapy or chemo-photothermal therapy with the DOX-loaded MMSN/GQDs nanosystem exhibits a significant synergistic effect, resulting in a higher efficacy to kill cancer cells. Therefore, the MMSN/GQDs multifunctional platform has great potential in cancer therapy for enhancing the therapeutic efficiency.read more
Citations
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pH-Responsive polyelectrolyte coated gadolinium oxide-doped mesoporous silica nanoparticles (Gd2O3@MSNs) for synergistic drug delivery and magnetic resonance imaging enhancement.
TL;DR: This work provides a feasible strategy to fabricate theranostic nanovectors with controlled release behavior triggered by mildly acidic pH and high-performance MR imaging capability.
Journal ArticleDOI
Nanomagnetic liposome-encapsulated parthenolide and indocyanine green for targeting and chemo-photothermal antitumor therapy.
TL;DR: The designed ICG-PTL-Lips@MNPs possess synergistic effects of chemotherapy, photothermal and targeting therapy, which are expected to provide an alternative way to further improve antitumor efficacy.
Journal ArticleDOI
Antifungal and Antibacterial Properties of Graphene-based Nanomaterials: A Mini-review
TL;DR: This review summarized the latest progresses towards an understanding of the antifungal and antibacterial properties of GBNs for developing a new antif fungus and antimicrobial nanomaterials.
Journal ArticleDOI
Facile fabrication of acid-resistant and hydrophobic Fe3O4@SiO2@C magnetic particles for valid oil-water separation application
TL;DR: In this article, the stability of magnetic Fe3O4 nanoparticles could be substantially improved after double coating with silica and carbon, which is the first time that the inorganic shells showed a great interfacial activity.
Journal ArticleDOI
Versatile Nanoplatform Loaded with Doxorubicin and Graphene Quantum Dots/Methylene Blue for Drug Delivery and Chemophotothermal/Photodynamic Synergetic Cancer Therapy
Liang Junlong,Jianjun Liu,Jin Xiaokang,Shuting Yao,Chen Biling,Qianwei Huang,Hu Jinhua,Junmin Wan,Zhiwen Hu,Wang Bing +9 more
TL;DR: The pH-responsive multifunctional nanoparticles prepared by a facile strategy have a high tumor cell-killing efficacy, manifesting excellent potential in synergistic therapy.
References
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A mesoporous silica nanosphere-based carrier system with chemically removable CdS nanoparticle caps for stimuli-responsive controlled release of neurotransmitters and drug molecules.
Cheng-Yu Lai,Brian G. Trewyn,Dusan M. Jeftinija,Ksenija Jeftinija,Shu Xu,Srdija Jeftinija,Victor S.-Y. Lin +6 more
TL;DR: An MCM-41 type mesoporous silica nanosphere-based controlled-release delivery system has been synthesized and characterized using surface-derivatized cadmium sulfide nanocrystals as chemically removable caps to encapsulate several pharmaceutical drug molecules and neurotransmitters inside the organically functionalized MSN Mesoporous framework.
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Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery
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Functionalized mesoporous silica materials for controlled drug delivery
TL;DR: This review highlights the most recent research progress on silica-based controlled drug delivery systems, including pure mesoporous silica sustained-release systems, magnetism and/or luminescence functionalized mesoporus silica systems which integrate targeting and tracking abilities of drug molecules.
Journal ArticleDOI
Unusual infrared-absorption mechanism in thermally reduced graphene oxide
Muge Acik,Geunsik Lee,Cecilia Mattevi,Cecilia Mattevi,Manish Chhowalla,Manish Chhowalla,Kyeongjae Cho,Yves J. Chabal +7 more
TL;DR: The observation of a giant-infrared-absorption band in reduced graphene oxide is reported, arising from the coupling of electronic states to the asymmetric stretch mode of a yet-unreported structure, consisting of oxygen atoms aggregated at the edges of defects.
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Multifunctional Mesoporous Silica-Coated Graphene Nanosheet Used for Chemo-Photothermal Synergistic Targeted Therapy of Glioma
TL;DR: These findings provided an excellent drug delivery system for combined therapy of glioma due to the advanced chemo-photothermal synergistic targeted therapy and good drug release properties of GSPID, which could effectively avoid frequent and invasive dosing and improve patient compliance.