Health benefits and health claims of probiotics: bridging science and marketing
Ger T. Rijkers,Willem M. de Vos,Robert-Jan M. Brummer,Lorenzo Morelli,Gérard Corthier,Philippe Marteau +5 more
TLDR
An open dialogue between basic and clinical scientists, regulatory authorities, food and nutrition industry, and consumers could bridge the gap between science and marketing of probiotics.Abstract:
Health claims for probiotics are evaluated by the Panel on Dietetic Products, Nutrition and Allergies of the European Food Safety Authority. Despite a substantial amount of basic and clinical research on the beneficial effects of probiotics, all of the evaluated claim applications thus far have received a negative opinion. With the restrictions on the use of clinical endpoints, validated biomarkers for gut health and immune health in relation to reduction in disease risk are needed. Clear-cut criteria for design as well as evaluation of future studies are needed. An open dialogue between basic and clinical scientists, regulatory authorities, food and nutrition industry, and consumers could bridge the gap between science and marketing of probiotics.read more
Citations
More filters
Journal ArticleDOI
Reappraisal of probiotics' safety in human.
TL;DR: The existing evidence suggests careful evaluation of the risk-benefit ratio of probiotics prior to prescription or recommendation to use, and the most at-risk groups consist of infants, elderly people, patients in hospitalized condition, and those with immunodeficiency due to a genetic or acquired disease.
Journal ArticleDOI
Versatile carboxymethyl chitin and chitosan nanomaterials: a review
TL;DR: This review provides an overview of the characteristics of CMC/CMCS NPs as well as fulfills the task of describing and discussing its important roles primarily in cancer nanomedicine detailing the targeted drug delivery aspect.
Journal ArticleDOI
Recommendations on reporting requirements for flavonoids in research
Douglas A. Balentine,Johanna T. Dwyer,John W. Erdman,Mario G. Ferruzzi,P. Courtney Gaine,James M. Harnly,Catherine Kwik-Uribe +6 more
TL;DR: Limitations commonly encountered in the field of flavonoid research are outlined, including the inconsistent use of nomenclature, inappropriate analytic methods, inconsistentuse of existing flavonoids databases, and the lack of full consideration in the design of test materials for intervention trials.
Journal ArticleDOI
Weissella cibaria WIKIM28 ameliorates atopic dermatitis-like skin lesions by inducing tolerogenic dendritic cells and regulatory T cells in BALB/c mice.
Seul Ki Lim,Min-Sung Kwon,Ji Eun Lee,Young J. Oh,Ja-Young Jang,Jong-Hee Lee,Hae Woong Park,Young-Do Nam,Myung-Ji Seo,Seong Woon Roh,Hak Jong Choi +10 more
TL;DR: Oral administration of W. cibaria WIKIM28 isolated from gatkimchi ameliorated AD-like symptoms by suppressing allergic Th2 responses and inducing Treg responses, suggesting that W. Cibaria may be applicable as a probiotic for the prevention and amelIORation of AD.
Journal ArticleDOI
Yogurt and Cardiometabolic Diseases: A Critical Review of Potential Mechanisms.
TL;DR: The plausibility of potential mechanisms commonly cited in the literature are investigated in order to shed light on the inverse associations reported between yogurt intake and various cardiometabolic health parameters that are related to its nutrient profile, bacterial constituents, and food matrix.
References
More filters
Journal ArticleDOI
A human gut microbial gene catalogue established by metagenomic sequencing
Junjie Qin,Ruiqiang Li,Jeroen Raes,Manimozhiyan Arumugam,Kristoffer Sølvsten Burgdorf,Chaysavanh Manichanh,Trine Nielsen,Nicolas Pons,Florence Levenez,Takuji Yamada,Daniel R. Mende,Junhua Li,Junming Xu,Shaochuan Li,Dongfang Li,Jianjun Cao,Bo Wang,Huiqing Liang,Huisong Zheng,Yinlong Xie,Julien Tap,Patricia Lepage,Marcelo Bertalan,Jean-Michel Batto,Torben Hansen,Denis Le Paslier,Allan Linneberg,H. Bjørn Nielsen,Eric Pelletier,Pierre Renault,Thomas Sicheritz-Pontén,Keith Turner,Hongmei Zhu,Chang Yu,Shengting Li,Min Jian,Yan Zhou,Yingrui Li,Xiuqing Zhang,Songgang Li,Nan Qin,Huanming Yang,Jian Wang,Søren Brunak,Joël Doré,Francisco Guarner,Karsten Kristiansen,Oluf Pedersen,Julian Parkhill,Jean Weissenbach,Peer Bork,S. Dusko Ehrlich,Jun Wang +52 more
TL;DR: The Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million non-redundant microbial genes, derived from 576.7 gigabases of sequence, from faecal samples of 124 European individuals are described, indicating that the entire cohort harbours between 1,000 and 1,150 prevalent bacterial species and each individual at least 160 such species.
Journal ArticleDOI
A microbial symbiosis factor prevents intestinal inflammatory disease
TL;DR: It is reported here that the prominent human symbiont Bacteroides fragilis protects animals from experimental colitis induced by Helicobacter hepaticus and that molecules of the bacterial microbiota can mediate the critical balance between health and disease.
Journal ArticleDOI
Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians
Elena Biagi,Lotta Nylund,Lotta Nylund,Marco Candela,Rita Ostan,Laura Bucci,Elisa Pini,Janne Nikkilä,Daniela Monti,Reetta Satokari,Claudio Franceschi,Patrizia Brigidi,Willem M. de Vos,Willem M. de Vos +13 more
TL;DR: Evidence is provided for the fact that the ageing process deeply affects the structure of the human gut microbiota, as well as its homeostasis with the host's immune system, because of its crucial role in the host physiology and health status.
Journal ArticleDOI
Nonclassic Actions of Vitamin D
TL;DR: The nonclassic actions of vitamin D are cell specific and provide a number of potential new clinical applications for 1,25(OH)(2)D(3) and its analogs, however, the use ofitamin D metabolites and analogs for these applications remains limited by the classic actions of Vitamin D leading to hypercalcemia and hypercalcuria.
Journal ArticleDOI
Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens
TL;DR: This Review highlights the documented signalling interactions of the surface molecules of probiotic bacteria (such as long surface appendages, polysaccharides and lipoteichoic acids) with PRRs with respect to host pattern recognition receptors of the gastrointestinal mucosa.
Related Papers (5)
Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial
Marc G. Besselink,Hjalmar C. van Santvoort,Erik Buskens,Erik Buskens,Marja A. Boermeester,Harry van Goor,Harro M. Timmerman,Vincent B. Nieuwenhuijs,Thomas L. Bollen,Bert van Ramshorst,Ben J.M. Witteman,Camiel Rosman,Rutger J. Ploeg,Menno A. Brink,Alexander F. Schaapherder,Cornelis H. C. Dejong,Peter J. Wahab,Cees J. H. M. van Laarhoven,Erwin van der Harst,Casper H.J. van Eijck,Miguel A. Cuesta,Louis M. A. Akkermans,Hein G. Gooszen +22 more
A human gut microbial gene catalogue established by metagenomic sequencing
Junjie Qin,Ruiqiang Li,Jeroen Raes,Manimozhiyan Arumugam,Kristoffer Sølvsten Burgdorf,Chaysavanh Manichanh,Trine Nielsen,Nicolas Pons,Florence Levenez,Takuji Yamada,Daniel R. Mende,Junhua Li,Junming Xu,Shaochuan Li,Dongfang Li,Jianjun Cao,Bo Wang,Huiqing Liang,Huisong Zheng,Yinlong Xie,Julien Tap,Patricia Lepage,Marcelo Bertalan,Jean-Michel Batto,Torben Hansen,Denis Le Paslier,Allan Linneberg,H. Bjørn Nielsen,Eric Pelletier,Pierre Renault,Thomas Sicheritz-Pontén,Keith Turner,Hongmei Zhu,Chang Yu,Shengting Li,Min Jian,Yan Zhou,Yingrui Li,Xiuqing Zhang,Songgang Li,Nan Qin,Huanming Yang,Jian Wang,Søren Brunak,Joël Doré,Francisco Guarner,Karsten Kristiansen,Oluf Pedersen,Julian Parkhill,Jean Weissenbach,Peer Bork,S. Dusko Ehrlich,Jun Wang +52 more