Health benefits and health claims of probiotics: bridging science and marketing
Ger T. Rijkers,Willem M. de Vos,Robert-Jan M. Brummer,Lorenzo Morelli,Gérard Corthier,Philippe Marteau +5 more
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TLDR
An open dialogue between basic and clinical scientists, regulatory authorities, food and nutrition industry, and consumers could bridge the gap between science and marketing of probiotics.Abstract:
Health claims for probiotics are evaluated by the Panel on Dietetic Products, Nutrition and Allergies of the European Food Safety Authority. Despite a substantial amount of basic and clinical research on the beneficial effects of probiotics, all of the evaluated claim applications thus far have received a negative opinion. With the restrictions on the use of clinical endpoints, validated biomarkers for gut health and immune health in relation to reduction in disease risk are needed. Clear-cut criteria for design as well as evaluation of future studies are needed. An open dialogue between basic and clinical scientists, regulatory authorities, food and nutrition industry, and consumers could bridge the gap between science and marketing of probiotics.read more
Citations
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Intestinal permeability – a new target for disease prevention and therapy
Stephan C. Bischoff,Giovanni Barbara,Wim A. Buurman,Theo Ockhuizen,Jörg-Dieter Schulzke,Matteo Serino,Herbert Tilg,Alastair J.M. Watson,Jerry M. Wells +8 more
TL;DR: Intestinal permeability, which is a feature of intestinal barrier function, is increasingly recognized as being of relevance for health and disease, and therefore, this topic warrants more attention.
Journal ArticleDOI
Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features
Niv Zmora,Niv Zmora,Gili Zilberman-Schapira,Jotham Suez,Uria Mor,Mally Dori-Bachash,Stavros Bashiardes,Eran Kotler,Maya Zur,Dana Regev-Lehavi,Rotem Ben-Zeev Brik,Sara Federici,Yotam Cohen,Raquel Linevsky,Daphna Rothschild,Andreas E. Moor,Shani Ben-Moshe,Alon Harmelin,Shalev Itzkovitz,Nitsan Maharshak,Nitsan Maharshak,Oren Shibolet,Oren Shibolet,Hagit Shapiro,Meirav Pevsner-Fischer,Itai Sharon,Zamir Halpern,Zamir Halpern,Eran Segal,Eran Elinav +29 more
TL;DR: The metagenomically characterized the murine and human mucosal-associated gastrointestinal microbiome and found it to only partially correlate with stool microbiome, indicating that empiric probiotics supplementation may be limited in universally and persistently impacting the gut mucosa.
Journal ArticleDOI
Microorganisms with claimed probiotic properties: an overview of recent literature.
TL;DR: Caution in selecting and monitoring of probiotics for patients is needed and complete consideration of risk-benefit ratio before prescribing is recommended, as probiotic properties have been shown to be strain specific, accurate identification of particular strains is also very important.
Journal ArticleDOI
The pros, cons, and many unknowns of probiotics
TL;DR: This Perspective highlights key advances, challenges and limitations in striving toward an unbiased interpretation of the large amount of data regarding over-the-counter probiotics, and proposes avenues to improve the quality of evidence, transparency, public awareness and regulation of their use.
Journal ArticleDOI
Beneficial Metabolic Effects of a Probiotic via Butyrate-induced GLP-1 Hormone Secretion
TL;DR: It is demonstrated that the administration of a probiotic, VSL#3, prevented and treated obesity and diabetes in several mouse models and suggested that probiotics can modulate the gut microbiota-SCFA-hormone axis.
References
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