High-affinity peptide against MT1-MMP for in vivo tumor imaging
Lei Zhu,Huiling Wang,Lin Wang,Ye Wang,Kun Jiang,Cheng Li,Qingjie Ma,Shi Gao,Liping Wang,Wei Li,Mingjun Cai,Hongda Wang,Gang Niu,Seulki Lee,Wei Yang,Xuexun Fang,Xiaoyuan Chen +16 more
TLDR
MT1-AF7p is an important tool for noninvasive monitoring of MT1-MMP expression in tumors, and it shows great potential as an imaging agent for MT1 -MMP-positive tumors.About:
This article is published in Journal of Controlled Release.The article was published on 2011-03-30 and is currently open access. It has received 60 citations till now. The article focuses on the topics: Imaging agent & Peptide library.read more
Citations
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PET imaging of inflammation biomarkers
TL;DR: The potential inflammation imaging targets and corresponding PET tracers, and the applications of PET in major inflammatory diseases and tumor associated inflammation are summarized.
Journal ArticleDOI
Recent advances in brain tumor-targeted nano-drug delivery systems
TL;DR: The concept of ‘whole-process targeting’ for brain tumor for nano-drug delivery systems, referring to a series of overall targeted drug delivery strategies aimed at key points during the whole development of brain tumors, is proposed.
Journal ArticleDOI
Hybrid graphene/Au activatable theranostic agent for multimodalities imaging guided enhanced photothermal therapy.
TL;DR: A fluorescent/photoacoustic imaging guided PTT agent by seeding Gold (Au) nanoparticles onto graphene oxide (GO) forming tumor targeted theranostic probe (CPGA), which found the photothermal effect of GA hybrid was found significantly elevated compared with Au or GO alone.
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Visualization of Protease Activity In Vivo Using an Activatable Photo-Acoustic Imaging Probe Based on CuS Nanoparticles
Kai Yang,Lei Zhu,Liming Nie,Xiaolian Sun,Liang Cheng,Chenxi Wu,Gang Niu,Xiaoyuan Chen,Zhuang Liu +8 more
TL;DR: This work presents a novel strategy of in vivo sensing of MMPs based on PA imaging, which should offer remarkably improved detection depth compared with traditional optical imaging techniques.
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The influence of the penetrating peptide iRGD on the effect of paclitaxel-loaded MT1-AF7p-conjugated nanoparticles on glioma cells.
Guangzhi Gu,Xiaoling Gao,Quanyin Hu,Ting Kang,Zhongyang Liu,Mengyin Jiang,Deyu Miao,Qingxiang Song,Lei Yao,Yifan Tu,Zhiqing Pang,Hong-Zhuan Chen,Xinguo Jiang,Jun Chen +13 more
TL;DR: The findings suggested that the BTB/glioma cells dual-targeting DDS co-administrated with iRGD peptide might provide a both practical and feasible solution to highly efficient anti-glioblastoma drug delivery.
References
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New functions for the matrix metalloproteinases in cancer progression
Mikala Egeblad,Zena Werb +1 more
TL;DR: It is shown that the MMPs have functions other than promotion of invasion, have substrates other than components of the extracellular matrix, and that they function before invasion in the development of cancer.
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Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
TL;DR: In addition to their role in extracellular matrix turnover and cancer cell migration, MMPs regulate signaling pathways that control cell growth, inflammation, or angiogenesis and may even work in a nonproteolytic manner.
Journal ArticleDOI
Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase ISOLATION OF THE ACTIVATED FORM OF THE MEMBRANE METALLOPROTEASE
Alex Y. Strongin,Ivan E. Collier,Gregory A. Bannikov,Barry L. Marmer,Gregory A. Grant,Gregory I. Goldberg +5 more
TL;DR: Activation of 72T4Cl on the cell membrane provides a basic mechanism for spatially regulated extracellular proteolysis and presents a new target for prognosis and treatment of metastatic disease.
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MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover
Kenn Holmbeck,Paolo Bianco,John J. Caterina,Susan Yamada,Mark Kromer,Sergei A. Kuznetsov,Mahesh H. Mankani,Pamela Gehron Robey,A. Robin Poole,Isabelle Pidoux,Jerrold M. Ward,Henning Birkedal-Hansen +11 more
TL;DR: The findings demonstrate the pivotal function of MT1-MMP in connective tissue metabolism, and illustrate that modeling of the soft connective tissues matrix by resident cells is essential for the development and maintenance of the hard tissues of the skeleton.
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Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion
Katarina Wolf,Yi I. Wu,Yi I. Wu,Yueying Liu,Jörg Geiger,Eric M. Tam,Eric M. Tam,Christopher M. Overall,M. Sharon Stack,Peter Friedl +9 more
TL;DR: Both ECM track widening and transition to multicellular invasion are dependent on MT1-MMP-mediated collagenolysis, shown by broad-spectrum protease inhibition and RNA interference, and invasive migration and proteolytic ECM remodelling are interdependent processes that control tissue micropatterning and macrop atterning.
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Laetitia Devy,Lili Huang,Laurent Naa,Niranjan Yanamandra,Henk Pieters,Nicolas Frans,Edward F. Chang,Qingfeng Tao,Marc Vanhove,Annabelle Lejeune,Reinoud van Gool,Daniel J. Sexton,Guannan Kuang,Douglas Rank,Shannon Hogan,Csaba Pazmany,Yu Lu Ma,Sonia Schoonbroodt,Andrew E. Nixon,Robert Charles Ladner,Rene Hoet,Paula Henderikx,Chris TenHoor,Shafaat A. Rabbani,Maria-Luisa Valentino,Clive R. Wood,Daniel T. Dransfield +26 more