Journal ArticleDOI
High-density lipoproteins: A consensus statement from the National Lipid Association
Peter P. Toth,Peter P. Toth,Philip J. Barter,Robert S. Rosenson,William E. Boden,M. John Chapman,Marina Cuchel,Ralph B. D'Agostino,Michael H. Davidson,W. Sean Davidson,Jay W. Heinecke,Richard H. Karas,Anatol Kontush,Ronald M. Krauss,Michael Miller,Daniel J. Rader +15 more
TLDR
In this article, an expert panel was formed to evaluate the current status of HDL-C as a therapeutic target; to review the current state of knowledge of HDL particle structure, composition, and function; and to identify the salient questions yet to be answered about the role of HDL in either preventing or contributing to atherosclerotic disease.About:
This article is published in Journal of Clinical Lipidology.The article was published on 2013-09-01. It has received 277 citations till now.read more
Citations
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Journal ArticleDOI
HDL and cardiovascular disease
Daniel J. Rader,G. Kees Hovingh +1 more
TL;DR: The cholesterol contained within HDL is inversely associated with risk of coronary heart disease and is a key component of predicting cardiovascular risk, however, despite its properties consistent with atheroprotection, the causal relation between HDL and atherosclerosis is uncertain.
Journal ArticleDOI
Pathophysiology of Type 2 Diabetes Mellitus.
Unai Galicia-Garcia,Asier Benito-Vicente,Shifa Jebari,Asier Larrea-Sebal,Haziq Siddiqi,Kepa B. Uribe,Helena Ostolaza,César Martín +7 more
TL;DR: This review analyzes the key aspects of type 2 Diabetes Mellitus, as well as the molecular mechanisms and pathways implicated in insulin metabolism leading to T2DM and insulin resistance, and summarizes the data gathered up until now.
Book ChapterDOI
Likelihood Modelling: Presentation of Multivariate Data for Clinical Use: The Framingham Study Risk Score Functions
TL;DR: An effort to make available a tool for clinicians to aid in their decision-making process regarding treatment and to assist them in motivating patients toward healthy behaviours is made available.
Journal ArticleDOI
HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells
Fatiha Tabet,Kasey C. Vickers,Luisa F. Cuesta Torres,Carrie B. Wiese,Bassem M. Shoucri,Gilles Lambert,Claire Catherinet,Leonel Prado-Lourenco,Michael G. Levin,Seth G. Thacker,Praveen Sethupathy,Philip J. Barter,Alan T. Remaley,Kerry-Anne Rye +13 more
TL;DR: It is demonstrated that HDL's anti-inflammatory properties are conferred, in part, through HDL-miR-223 delivery and translational repression of ICAM-1 in endothelial cells.
Journal ArticleDOI
Soy and Health Update: Evaluation of the Clinical and Epidemiologic Literature
TL;DR: This review covers each of the major research areas involving soy focusing primarily on the clinical and epidemiologic research, and supports the safety and benefits of soyfoods.
References
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Journal ArticleDOI
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Scott M. Grundy,David W. Bilheimer,Alan Chait,Luther T. Clark,Margo A. Denke,Richard J. Havel,William R. Hazzard,Stephen B. Hulley,Donald B. Hunninghake,Robert A. Kreisberg,Penny M. Kris-Etherton,James M. McKenney,Michael A. Newman,Ernst J. Schaefer,Burton E. Sobel,Carolyn Somelofski,Milton C. Weinstein,H. Bryan Brewer,James I. Cleeman,Karen A. Donato,Nancy D. Ernst,Jeffrey M. Hoeg,Basil M. Rifkind,Jacques E. Rossouw,Christopher T. Sempos,Joanne M. Gallivan,Maureen N. Harris,Laurie Quint-Adler +27 more
TL;DR: Dairy therapy remains the first line of treatment of high blood cholesterol, and drug therapy is reserved for patients who are considered to be at high risk for CHD, and the fundamental approach to treatment is comparable.
Journal ArticleDOI
Atherosclerosis — An Inflammatory Disease
TL;DR: Atherosclerosis is an inflammatory disease as discussed by the authors, and it is a major cause of death in the United States, Europe, and much of Asia, despite changes in lifestyle and use of new pharmacologic approaches to lower plasma cholesterol concentrations.
Journal ArticleDOI
The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum
TL;DR: The relatively low density of the lipoproteins was utilized by Lindgren, Elliott, and Gofman to separate them from the other serum proteins by ultracentrifugal flotation, and quantitation was subsequently performed by refractometric methods in the analytical ultracentRifuge.
Journal ArticleDOI
Implications of Recent Clinical Trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines
Scott M. Grundy,James I. Cleeman,C. Noel Bairey Merz,H. Bryan Brewer,Luther T. Clark,Donald B. Hunninghake,Richard C. Pasternak,Sidney C. Smith,Neil J. Stone +8 more
TL;DR: The trials confirm the benefit of cholesterol-lowering therapy in high-risk patients and support the ATP III treatment goal of low-density lipoprotein cholesterol (LDL-C) <100 mg/dL, and confirm that older persons benefit from therapeutic lowering of LDL-C.
Journal ArticleDOI
General Cardiovascular Risk Profile for Use in Primary Care The Framingham Heart Study
Ralph B. D'Agostino,Ramachandran S. Vasan,Michael J. Pencina,Philip A. Wolf,Mark R. Cobain,Joseph M. Massaro,William B. Kannel +6 more
TL;DR: A sex-specific multivariable risk factor algorithm can be conveniently used to assess general CVD risk and risk of individual CVD events (coronary, cerebrovascular, and peripheral arterial disease and heart failure) and can be used to quantify risk and to guide preventive care.
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