High-fat diet-induced obesity in animal models
Niloofar Hariri,Louise Thibault +1 more
TLDR
The history of using high-fat diets to induce obesity in animals is described, the consequences of changing the amount and type of dietary fats on weight gain, body composition and adipose tissue cellularity are clarified, and the contribution of genetics and sex is explored.Abstract:
Epidemiological studies have shown a positive relationship between dietary fat intake and obesity Since rats and mice show a similar relationship, they are considered an appropriate model for studying dietary obesity The present paper describes the history of using high-fat diets to induce obesity in animals, aims to clarify the consequences of changing the amount and type of dietary fats on weight gain, body composition and adipose tissue cellularity, and explores the contribution of genetics and sex, as well as the biochemical basis and the roles of hormones such as leptin, insulin and ghrelin in animal models of dietary obesity The major factors that contribute to dietary obesity - hyperphagia, energy density and post-ingestive effects of the dietary fat - are discussed Other factors that affect dietary obesity including feeding rhythmicity, social factors and stress are highlighted Finally, we comment on the reversibility of high-fat diet-induced obesityread more
Citations
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Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States.
TL;DR: An overview of the cellular and molecular biology of brain aging, how those processes interface with disease-specific neurodegenerative pathways, and how metabolic states influence brain health is provided.
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Overview of animal models of obesity.
Thomas A. Lutz,Stephen C. Woods +1 more
TL;DR: The focus of this overview is on the animal models of obesity most commonly utilized in research, including monogenic models in the leptin pathway, polygenic diet‐dependent models, and, in particular for their historical perspective, surgical and chemical models of Obesity.
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Negative Effects of a High-Fat Diet on Intestinal Permeability: A Review
TL;DR: A high-fat diet enhances intestinal permeability directly and negatively modulates the intestinal mucus composition and enriches the gut microflora with barrier-disrupting species, as well as highlighting the various ways an HFD disrupts the gut barrier system and its many implications in human health.
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Impact of Obesity on Influenza A Virus Pathogenesis, Immune Response, and Evolution.
TL;DR: This review comprehensively analyzes the recent literature on how and why viral pathogenesis is altered in the obese host along with the impact of the altered host and pathogenic state on viral evolutionary dynamics in multiple models.
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Changes in intestinal barrier function and gut microbiota in high-fat diet fed rats are dynamic and region-dependent
TL;DR: Understanding of microbiota dysbiosis and gut pathophysiology in diet-induced obesity is provided and IL-10 and Oscillospira in the ileum and transcellular flux in the large intestine are identified as potential early impairments in the gut that might lead to obesity and metabolic disorders.
References
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