Journal ArticleDOI
HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS)
Chloe L. Thio,Eric C. Seaberg,Richard L. Skolasky,John P. Phair,Barbara R. Visscher,Alvaro Muñoz,David L. Thomas +6 more
TLDR
Individuals coinfected with HIV-1 and HBV, especially those with low CD4+ nadir counts, are at increased risk for liver-related mortality, underscoring the importance of prevention, identification, and comprehensive management of hepatitis B in people infected withAIDS.Citations
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HBV-HIV coinfection: Key clinical management issues
Frank Trinh,Vivian Levy +1 more
TL;DR: HBV treatment requires balancing the need for antiretroviral therapy and the severity of liver disease with the risk of drug-resistant HBV and HIV variants, so patients who have received therapy for HBV infection should help guide treatment selection.
Journal ArticleDOI
Transaminase (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)) Activity of HIVFemale Patients on Drugs and Female Patients Not on Drugs
Arome Solomon Odiba,Onosakponome Iruoghene,Okechukwu Kalu Iroha,Ukegbu Chimere Young,K.O. Omeje +4 more
TL;DR: A correlation plot between ALT and AST levels showed a non-significant correlation between these transaminases in the three groups and a month-by-month documentation of the prescribed drug combination provided an avenue for calculating each patient's individual cumulative drug exposure.
Book ChapterDOI
Combination therapy against human infections caused by viruses
Rifat Munir,Rifat Munir +1 more
TL;DR: A number of antiviral agents are in advanced stages of clinical research to be used as combination drugs and they potentially offer promising clinical outcomes by reducing the emergence of resistance, improving antiviral potency, and extending the treatment window.
Journal ArticleDOI
Evaluation of sero-prevalence of HIV and hepatitis B co-infection among subjects in Orashi communities of Niger delta
TL;DR: The study highlights that females are more vulnerable to sexually-transmitted diseases more than their male counterparts, which may have accounted for the increased prevalence of HIV/HBV prevalence among females.
References
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Journal Article
Statistical methods in cancer research. Volume II--The design and analysis of cohort studies.
N. E. Breslow,N. E. Day +1 more
TL;DR: What do you do to start reading statistical methods in cancer research vol ii the design and analysis of cohort studies?
Journal ArticleDOI
The Prevalence of Hepatitis C Virus Infection in the United States, 1988 through 1994
Miriam J. Alter,Deanna Kruszon-Moran,Omana V. Nainan,Geraldine M. McQuillan,Fengxiang Gao,Linda A. Moyer,Richard A. Kaslow,Harold S. Margolis +7 more
TL;DR: The strongest factors independently associated with HCV infection were illegal drug use and high-risk sexual behavior, and poverty, having had 12 or fewer years of education, and having been divorced or separated were independently associated.
Journal ArticleDOI
Liver fibrosis progression in human immunodeficiency virus and hepatitis C virus coinfected patients
Yves Benhamou,Marie Bochet,V. Di Martino,Frédéric Charlotte,F. Azria,Anne Coutellier,Michel Vidaud,François Bricaire,Pierre Opolon,Christine Katlama,Thierry Poynard +10 more
TL;DR: In coinfected patients, a low CD4 count, alcohol consumption rate, and age at HCV infection are associated with a higher liver fibrosis progression rate, while HIV seropositivity accelerates HCV‐related liver Fibrosis progression.
Journal ArticleDOI
The multicenter aids cohort study: rationale, organization, and selected characteristics of the participants
TL;DR: The Multicenter AIDS Cohort Study was designed to elucidate the natural history of the infection causing acquired immunodeficiency syndrome (AIDS), identify risk factors for occurrence and clinical expression of the virus, and establish a repository of biologic specimens for future study.
Journal ArticleDOI
Hepatotoxicity associated with antiretroviral therapy in adults infected with human immunodeficiency virus and the role of hepatitis C or B virus infection.
TL;DR: The data indicate that use of ritonavir may increase risk of severe hepatotoxicity, and does not support withholding protease inhibitor therapy from persons coinfected with hepatitis B or C virus.