Journal ArticleDOI
HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS)
Chloe L. Thio,Eric C. Seaberg,Richard L. Skolasky,John P. Phair,Barbara R. Visscher,Alvaro Muñoz,David L. Thomas +6 more
TLDR
Individuals coinfected with HIV-1 and HBV, especially those with low CD4+ nadir counts, are at increased risk for liver-related mortality, underscoring the importance of prevention, identification, and comprehensive management of hepatitis B in people infected withAIDS.Citations
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Obstacles to HBV functional cure: Late presentation in HIV and its impact on HBV seroconversion in HIV/HBV coinfection.
Kathrin van Bremen,Christian Hoffmann,Stefan Mauss,Thomas A. Lutz,Patrick Ingiliz,Christoph D. Spinner,Stefan Scholten,Carolynne Schwarze-Zander,Florian Berger,Sven Breitschwerdt,Stephan M Schneeweiss,Fabian Busch,Jan-Christian Wasmuth,Gerd Fätkenheuer,Clara Lehmann,Jürgen K. Rockstroh,Christoph Boesecke +16 more
TL;DR: Long‐term TDF‐containing cART appears to achieve higher rates of HBsAg seroclearance compared to published data for HBV monoinfected subjects, however, late presentation for HIV and poor immune recovery significantly impair HBV seroconversion rates.
Journal ArticleDOI
Epidemiology estimates of hepatitis D in individuals co-infected with human immunodeficiency virus and hepatitis B virus, 2002–2018: A systematic review and meta-analysis
TL;DR: In this article, the epidemiology of hepatitis delta virus (HDV) infection in HIV/HBV co-infected individuals was characterized by using the DerSimonian-Laird random-effects model and the estimated pooled HDV seroprevalence among the general population was 1.07% (95% CI 0.65-1.59).
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Prevalence and Characteristics of Hepatitis B Surface Antigenaemia among HIV Infected Patients in Jos, Nigeria
Oche Agbaji,Nimzing G. Ladep,Patricia A. Agaba,Bitrus Badung,Monday L. Danung,Godwin E. Imade,John A Idoko,Robert L. Murphy,Phyllis J. Kanki +8 more
TL;DR: This study analyzed HBsAg prevalence, its demographic distribution and relationship to the immunological and viral load status of HIV positive cohort in Jos between August 2004 and April 2005 to find out whether this may negatively impact their morbidity and mortality.
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Human immunodeficiency virus and hepatitis B genotype G/A2 recombinant co-infection: a case study.
Eisuke Adachi,Masaya Sugiyama,Sayaka Shimizu,Kako Kodama,Tadashi Kikuchi,Michiko Koga,Masashi Mizokami,Tomohiko Koibuchi +7 more
TL;DR: Recombination with other genotypes could alter the clinical manifestations of chronic hepatitis B in people living with HIV, and this recombinant strain was not identical to HBV/G/A2 strains previously reported from Japan.
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Prevalence of HIV and Its Co-Infection with Hepatitis B/C Virus Among Chronic Liver Disease Patients in Ethiopia
Yayehyirad Tassachew,Tamrat Abebe,Yeshambel Belyhun,Tezazu Teffera,Abate B. Shewaye,Hailemichael Desalegn,Henok Andualem,Abiy Kinfu,Andargachew Mulu,Adane Mihret,Rawleigh Howe,Abraham Aseffa +11 more
TL;DR: The frequency of HIV and its co-infections with HBV/HCV exhibited an increasing pattern with the severity of the liver disease and screening all HIV-positive patients for HBV and HCV infection and taking necessary preventive measures would be an essential strategy to prevent the progression of CLD and death related to liver disease in people living with HIV.
References
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Journal Article
Statistical methods in cancer research. Volume II--The design and analysis of cohort studies.
N. E. Breslow,N. E. Day +1 more
TL;DR: What do you do to start reading statistical methods in cancer research vol ii the design and analysis of cohort studies?
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The Prevalence of Hepatitis C Virus Infection in the United States, 1988 through 1994
Miriam J. Alter,Deanna Kruszon-Moran,Omana V. Nainan,Geraldine M. McQuillan,Fengxiang Gao,Linda A. Moyer,Richard A. Kaslow,Harold S. Margolis +7 more
TL;DR: The strongest factors independently associated with HCV infection were illegal drug use and high-risk sexual behavior, and poverty, having had 12 or fewer years of education, and having been divorced or separated were independently associated.
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Liver fibrosis progression in human immunodeficiency virus and hepatitis C virus coinfected patients
Yves Benhamou,Marie Bochet,V. Di Martino,Frédéric Charlotte,F. Azria,Anne Coutellier,Michel Vidaud,François Bricaire,Pierre Opolon,Christine Katlama,Thierry Poynard +10 more
TL;DR: In coinfected patients, a low CD4 count, alcohol consumption rate, and age at HCV infection are associated with a higher liver fibrosis progression rate, while HIV seropositivity accelerates HCV‐related liver Fibrosis progression.
Journal ArticleDOI
The multicenter aids cohort study: rationale, organization, and selected characteristics of the participants
TL;DR: The Multicenter AIDS Cohort Study was designed to elucidate the natural history of the infection causing acquired immunodeficiency syndrome (AIDS), identify risk factors for occurrence and clinical expression of the virus, and establish a repository of biologic specimens for future study.
Journal ArticleDOI
Hepatotoxicity associated with antiretroviral therapy in adults infected with human immunodeficiency virus and the role of hepatitis C or B virus infection.
TL;DR: The data indicate that use of ritonavir may increase risk of severe hepatotoxicity, and does not support withholding protease inhibitor therapy from persons coinfected with hepatitis B or C virus.